| 1 |
Clarus Ventures, LLC |
2,153,092 |
21,337,000 |
11.91% |
|
|
| 2 |
Invesco Ltd. |
1,783,754 |
17,677,000 |
9.86% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
1,377,497 |
13,651,000 |
7.62% |
|
|
| 4 |
Polar Capital LLP |
1,339,893 |
13,276,000 |
7.41% |
|
|
| 5 |
OppenheimerFunds, Inc. |
1,068,087 |
10,585,000 |
5.91% |
|
|
| 6 |
Redmile Group, LLC |
876,088 |
8,682,000 |
4.84% |
|
|
| 7 |
PRICE T ROWE ASSOCIATES INC /MD/ |
821,446 |
8,141,000 |
4.54% |
|
|
| 8 |
Alyeska Investment Group, L.P. |
801,101 |
7,939,000 |
4.43% |
|
|
| 9 |
LANSDOWNE PARTNERS (UK) LLP |
722,354 |
7,159,000 |
3.99% |
|
|
| 10 |
Cortina Asset Management, LLC |
683,847 |
6,777,000 |
3.78% |
|
|
| 11 |
Grandeur Peak Global Advisors, LLC |
636,410 |
6,307,000 |
3.52% |
|
|
| 12 |
AXA S.A. |
609,879 |
6,044,000 |
3.37% |
|
|
| 13 |
First Light Asset Management, LLC |
546,724 |
5,418,000 |
3.02% |
|
|
| 14 |
BlackRock Fund Advisors |
525,193 |
5,205,000 |
2.90% |
|
|
| 15 |
TIVERTON ASSET MANAGEMENT LLC |
504,000 |
4,995,000 |
2.79% |
|
|
| 16 |
Fosun International Ltd |
467,551 |
4,633,000 |
2.59% |
|
|
| 17 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
464,541 |
4,604,000 |
2.57% |
|
|
| 18 |
FIRST MANHATTAN CO. LLC. |
365,993 |
3,626,000 |
2.02% |
|
|
| 19 |
ACUTA CAPITAL PARTNERS, LLC |
308,044 |
3,053,000 |
1.70% |
|
|
| 20 |
WADDELL & REED FINANCIAL INC |
250,300 |
2,480,000 |
1.38% |
|
|
| 21 |
STATE STREET CORP |
235,187 |
2,329,000 |
1.30% |
|
|
| 22 |
NORTHERN TRUST CORP |
187,349 |
1,856,000 |
1.04% |
|
|
| 23 |
WASATCH ADVISORS LP |
187,651 |
1,740,000 |
0.97% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
167,971 |
1,665,000 |
0.93% |
|
|
| 25 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
84,600 |
838,000 |
0.47% |
|
|
| 26 |
RENAISSANCE TECHNOLOGIES LLC |
81,700 |
810,000 |
0.45% |
|
|
| 27 |
BlackRock Investment Management, LLC |
74,087 |
734,000 |
0.41% |
|
|
| 28 |
C WorldWide Group Holding A/S |
70,460 |
698,000 |
0.39% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,453 |
639,000 |
0.36% |
|
|
| 30 |
Birchview Capital, LP |
56,303 |
558,000 |
0.31% |
|
|
| 31 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
56,300 |
558,000 |
0.31% |
|
|
| 32 |
VANGUARD GROUP INC |
54,451 |
540,000 |
0.30% |
|
|
| 33 |
Spark Investment Management LLC |
52,700 |
522,000 |
0.29% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
42,676 |
423,000 |
0.24% |
|
|
| 35 |
Bank of New York Mellon Corp |
41,090 |
407,000 |
0.23% |
|
|
| 36 |
D. E. Shaw & Co., Inc. |
33,946 |
336,000 |
0.19% |
|
|
| 37 |
GEODE CAPITAL MANAGEMENT, LLC |
33,614 |
333,000 |
0.19% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29,400 |
292,000 |
0.16% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
29,361 |
291,000 |
0.16% |
|
|
| 40 |
KEYBANK NATIONAL ASSOCIATION/OH |
23,185 |
230,000 |
0.13% |
|
|
| 41 |
WALL STREET ASSOCIATES |
22,800 |
226,000 |
0.13% |
|
|
| 42 |
CASDIN CAPITAL, LLC |
20,000 |
198,000 |
0.11% |
|
|
| 43 |
RHUMBLINE ADVISERS |
18,330 |
182,000 |
0.10% |
|
|
| 44 |
NEW YORK STATE COMMON RETIREMENT FUND |
18,400 |
182,000 |
0.10% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
15,215 |
150,000 |
0.08% |
|
|
| 46 |
CITIGROUP INC |
14,066 |
139,000 |
0.08% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
14,492 |
134,000 |
0.07% |
|
|
| 48 |
Nationwide Fund Advisors |
13,511 |
134,000 |
0.07% |
|
|
| 49 |
GOLDMAN SACHS GROUP INC |
13,244 |
131,000 |
0.07% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
13,029 |
129,000 |
0.07% |
|
|
