| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 2,579,062 | 35,127,000 | 19.81% | ||
| 2 | Invesco Ltd. | 1,383,448 | 18,843,000 | 10.63% | ||
| 3 | New Leaf Venture Partners, L.L.C. | 1,377,497 | 18,762,000 | 10.58% | ||
| 4 | Redmile Group, LLC | 1,070,995 | 14,587,000 | 8.23% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 849,900 | 11,576,000 | 6.53% | ||
| 6 | LANSDOWNE PARTNERS (UK) LLP | 522,354 | 7,114,000 | 4.01% | ||
| 7 | OppenheimerFunds, Inc. | 516,227 | 7,031,000 | 3.96% | ||
| 8 | TIVERTON ASSET MANAGEMENT LLC | 512,100 | 6,974,000 | 3.93% | ||
| 9 | Cortina Asset Management, LLC | 506,378 | 6,897,000 | 3.89% | ||
| 10 | Fosun International Ltd | 467,551 | 6,368,000 | 3.59% | ||
| 11 | WELLS FARGO & COMPANY/MN | 442,513 | 6,027,000 | 3.40% | ||
| 12 | BlackRock Fund Advisors | 357,541 | 4,870,000 | 2.75% | ||
| 13 | Alyeska Investment Group, L.P. | 349,275 | 4,757,000 | 2.68% | ||
| 14 | AXA S.A. | 273,805 | 3,729,000 | 2.10% | ||
| 15 | First Light Asset Management, LLC | 273,473 | 3,725,000 | 2.10% | ||
| 16 | KORNITZER CAPITAL MANAGEMENT INC /KS | 253,569 | 3,454,000 | 1.95% | ||
| 17 | WALL STREET ASSOCIATES | 222,400 | 3,029,000 | 1.71% | ||
| 18 | DRIEHAUS CAPITAL MANAGEMENT LLC | 120,585 | 1,642,000 | 0.93% | ||
| 19 | NORTHERN TRUST CORP | 114,427 | 1,559,000 | 0.88% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 108,557 | 1,479,000 | 0.83% | ||
| 21 | STATE STREET CORP | 102,696 | 1,401,000 | 0.79% | ||
| 22 | C WorldWide Group Holding A/S | 100,460 | 1,368,000 | 0.77% | ||
| 23 | DEUTSCHE BANK AG\ | 65,006 | 884,000 | 0.50% | ||
| 24 | Waterstone Capital Management, L.P. | 62,461 | 851,000 | 0.48% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,927 | 694,000 | 0.39% | ||
| 26 | AMERIPRISE FINANCIAL INC | 47,945 | 653,000 | 0.37% | ||
| 27 | Bank of New York Mellon Corp | 39,877 | 542,000 | 0.31% | ||
| 28 | BlackRock Investment Management, LLC | 37,762 | 514,000 | 0.29% | ||
| 29 | Polar Capital LLP | 26,084 | 355,000 | 0.20% | ||
| 30 | PIPER SANDLER & CO. | 26,000 | 354,000 | 0.20% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,139 | 329,000 | 0.19% | ||
| 32 | VANGUARD GROUP INC | 20,767 | 283,000 | 0.16% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,100 | 261,000 | 0.15% | ||
| 34 | TEACHERS ADVISORS, LLC | 18,476 | 252,000 | 0.14% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 16,043 | 218,000 | 0.12% | ||
| 36 | Whetstone Capital Advisors, LLC | 16,000 | 218,000 | 0.12% | ||
| 37 | CREDIT SUISSE AG/ | 11,446 | 155,000 | 0.09% | ||
| 38 | Nationwide Fund Advisors | 9,954 | 136,000 | 0.08% | ||
| 39 | AMERICAN INTERNATIONAL GROUP, INC. | 8,177 | 111,371 | 0.06% | ||
| 40 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,679 | 77,000 | 0.04% | ||
| 41 | BLACKROCK ADVISORS LLC | 5,102 | 69,000 | 0.04% | ||
| 42 | CITIGROUP INC | 2,232 | 30,000 | 0.02% | ||
| 43 | BARCLAYS PLC | 741 | 10,000 | 0.01% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 600 | 8,000 | 0.00% | ||
| 45 | UBS Group AG | 556 | 8,000 | 0.00% | ||
| 46 | Tower Research Capital LLC (TRC) | 100 | 1,000 | 0.00% | ||
| 47 | BANK OF MONTREAL /CAN/ | 73 | 1,000 | 0.00% | ||
| 48 | MORGAN STANLEY | 8 | 0 | 0.00% | ||
| 49 | ROYAL BANK OF CANADA | 13 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
