| 1 |
Clarus Ventures, LLC |
2,153,092 |
19,378,000 |
12.23% |
|
|
| 2 |
Invesco Ltd. |
1,783,926 |
16,055,000 |
10.13% |
|
|
| 3 |
Redmile Group, LLC |
1,428,094 |
12,853,000 |
8.11% |
|
|
| 4 |
New Leaf Venture Partners, L.L.C. |
1,377,497 |
12,397,000 |
7.82% |
|
|
| 5 |
Polar Capital LLP |
1,340,871 |
12,067,000 |
7.61% |
|
|
| 6 |
Alyeska Investment Group, L.P. |
817,691 |
7,359,000 |
4.64% |
|
|
| 7 |
PRICE T ROWE ASSOCIATES INC /MD/ |
813,215 |
7,319,000 |
4.62% |
|
|
| 8 |
OppenheimerFunds, Inc. |
733,609 |
6,602,000 |
4.17% |
|
|
| 9 |
Grandeur Peak Global Advisors, LLC |
701,704 |
6,315,000 |
3.98% |
|
|
| 10 |
First Light Asset Management, LLC |
700,849 |
6,308,000 |
3.98% |
|
|
| 11 |
Cortina Asset Management, LLC |
610,353 |
5,493,000 |
3.47% |
|
|
| 12 |
AXA S.A. |
603,270 |
5,429,000 |
3.43% |
|
|
| 13 |
BlackRock Fund Advisors |
574,157 |
5,167,000 |
3.26% |
|
|
| 14 |
Fosun International Ltd |
467,551 |
4,208,000 |
2.66% |
|
|
| 15 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
464,541 |
4,181,000 |
2.64% |
|
|
| 16 |
ACUTA CAPITAL PARTNERS, LLC |
417,278 |
3,756,000 |
2.37% |
|
|
| 17 |
FIRST MANHATTAN CO. LLC. |
352,500 |
3,172,000 |
2.00% |
|
|
| 18 |
WASATCH ADVISORS LP |
274,198 |
2,468,000 |
1.56% |
|
|
| 19 |
WADDELL & REED FINANCIAL INC |
250,300 |
2,253,000 |
1.42% |
|
|
| 20 |
STATE STREET CORP |
244,102 |
2,194,000 |
1.38% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
178,919 |
1,610,000 |
1.02% |
|
|
| 22 |
NORTHERN TRUST CORP |
176,658 |
1,590,000 |
1.00% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
126,800 |
1,141,000 |
0.72% |
|
|
| 24 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
103,700 |
933,000 |
0.59% |
|
|
| 25 |
BlackRock Investment Management, LLC |
81,203 |
731,000 |
0.46% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
70,909 |
638,000 |
0.40% |
|
|
| 27 |
C WorldWide Group Holding A/S |
70,460 |
634,000 |
0.40% |
|
|
| 28 |
VANGUARD GROUP INC |
58,492 |
526,000 |
0.33% |
|
|
| 29 |
Birchview Capital, LP |
56,303 |
507,000 |
0.32% |
|
|
| 30 |
Bank of New York Mellon Corp |
51,899 |
467,000 |
0.29% |
|
|
| 31 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
50,705 |
456,000 |
0.29% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
46,546 |
419,000 |
0.26% |
|
|
| 33 |
KEYBANK NATIONAL ASSOCIATION/OH |
45,980 |
414,000 |
0.26% |
|
|
| 34 |
Spark Investment Management LLC |
39,200 |
352,000 |
0.22% |
|
|
| 35 |
GEODE CAPITAL MANAGEMENT, LLC |
36,236 |
326,000 |
0.21% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
33,382 |
300,000 |
0.19% |
|
|
| 37 |
D. E. Shaw & Co., Inc. |
30,914 |
278,000 |
0.18% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29,400 |
265,000 |
0.17% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
27,817 |
249,000 |
0.16% |
|
|
| 40 |
RHUMBLINE ADVISERS |
24,180 |
218,000 |
0.14% |
|
|
| 41 |
WALL STREET ASSOCIATES |
22,800 |
205,000 |
0.13% |
|
|
| 42 |
CREDIT SUISSE AG/ |
19,520 |
175,000 |
0.11% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
18,400 |
166,000 |
0.10% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
13,875 |
125,000 |
0.08% |
|
|
| 45 |
Nationwide Fund Advisors |
13,511 |
122,000 |
0.08% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
12,779 |
115,011 |
0.07% |
|
|
| 47 |
SG Americas Securities, LLC |
12,717 |
114,000 |
0.07% |
|
|
| 48 |
SOCIETE GENERALE |
12,717 |
114,000 |
0.07% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
12,602 |
113,000 |
0.07% |
|
|
| 50 |
VOYA INVESTMENT MANAGEMENT LLC |
11,500 |
104,000 |
0.07% |
|
|
