| 1 |
Clarus Ventures, LLC |
2,167,377 |
30,018,000 |
11.95% |
|
|
| 2 |
Invesco Ltd. |
1,783,835 |
24,706,000 |
9.84% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
1,377,497 |
19,078,000 |
7.60% |
|
|
| 4 |
Redmile Group, LLC |
1,212,892 |
16,799,000 |
6.69% |
|
|
| 5 |
OppenheimerFunds, Inc. |
1,063,527 |
14,730,000 |
5.87% |
|
|
| 6 |
Polar Capital LLP |
872,989 |
12,089,000 |
4.81% |
|
|
| 7 |
Alyeska Investment Group, L.P. |
866,026 |
11,994,000 |
4.78% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
859,900 |
11,910,000 |
4.74% |
|
|
| 9 |
TIVERTON ASSET MANAGEMENT LLC |
725,000 |
10,041,000 |
4.00% |
|
|
| 10 |
LANSDOWNE PARTNERS (UK) LLP |
722,354 |
10,005,000 |
3.98% |
|
|
| 11 |
Cortina Asset Management, LLC |
659,212 |
9,130,000 |
3.64% |
|
|
| 12 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
561,226 |
7,773,000 |
3.10% |
|
|
| 13 |
BlackRock Fund Advisors |
527,534 |
7,306,000 |
2.91% |
|
|
| 14 |
AXA S.A. |
516,665 |
7,156,000 |
2.85% |
|
|
| 15 |
Tamarack Capital Management, LLC |
504,668 |
6,990,000 |
2.78% |
|
|
| 16 |
Fosun International Ltd |
467,551 |
6,476,000 |
2.58% |
|
|
| 17 |
First Light Asset Management, LLC |
448,365 |
6,210,000 |
2.47% |
|
|
| 18 |
FIRST MANHATTAN CO. LLC. |
390,600 |
5,409,000 |
2.15% |
|
|
| 19 |
Grandeur Peak Global Advisors, LLC |
377,535 |
5,229,000 |
2.08% |
|
|
| 20 |
WALL STREET ASSOCIATES |
260,100 |
3,602,000 |
1.43% |
|
|
| 21 |
STATE STREET CORP |
213,397 |
2,954,000 |
1.18% |
|
|
| 22 |
ACUTA CAPITAL PARTNERS, LLC |
197,680 |
2,738,000 |
1.09% |
|
|
| 23 |
NORTHERN TRUST CORP |
146,820 |
2,033,000 |
0.81% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
145,855 |
2,020,000 |
0.80% |
|
|
| 25 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
136,400 |
1,889,000 |
0.75% |
|
|
| 26 |
C WorldWide Group Holding A/S |
120,460 |
1,668,000 |
0.66% |
|
|
| 27 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
85,819 |
1,189,000 |
0.47% |
|
|
| 28 |
Granite Investment Partners, LLC |
71,076 |
985,000 |
0.39% |
|
|
| 29 |
BlackRock Investment Management, LLC |
70,345 |
974,000 |
0.39% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,453 |
893,000 |
0.36% |
|
|
| 31 |
Bank of New York Mellon Corp |
54,878 |
759,000 |
0.30% |
|
|
| 32 |
WASATCH ADVISORS LP |
51,982 |
720,000 |
0.29% |
|
|
| 33 |
FRIESS ASSOCIATES LLC |
48,200 |
668,000 |
0.27% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
36,787 |
509,000 |
0.20% |
|
|
| 35 |
VANGUARD GROUP INC |
34,249 |
474,000 |
0.19% |
|
|
| 36 |
PIPER SANDLER & CO. |
30,000 |
416,000 |
0.17% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29,400 |
408,000 |
0.16% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
29,361 |
407,000 |
0.16% |
|
|
| 39 |
RENAISSANCE TECHNOLOGIES LLC |
25,700 |
356,000 |
0.14% |
|
|
| 40 |
GEODE CAPITAL MANAGEMENT, LLC |
23,658 |
327,000 |
0.13% |
|
|
| 41 |
NEW YORK STATE COMMON RETIREMENT FUND |
19,238 |
266,000 |
0.11% |
|
|
| 42 |
D. E. Shaw & Co., Inc. |
17,238 |
239,000 |
0.10% |
|
|
| 43 |
RHUMBLINE ADVISERS |
15,730 |
218,000 |
0.09% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
14,810 |
205,000 |
0.08% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
13,941 |
194,000 |
0.08% |
|
|
| 46 |
CREDIT SUISSE AG/ |
13,234 |
183,000 |
0.07% |
|
|
| 47 |
Nationwide Fund Advisors |
12,876 |
178,000 |
0.07% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
11,804 |
163,485 |
0.07% |
|
|
| 49 |
BLACKROCK ADVISORS LLC |
10,112 |
140,000 |
0.06% |
|
|
| 50 |
CITIGROUP INC |
8,845 |
123,000 |
0.05% |
|
|
