| 1 |
FMR LLC |
6,314,452 |
56,956,000 |
44.51% |
|
|
| 2 |
HealthCor Management, L.P. |
1,575,000 |
14,207,000 |
11.10% |
|
|
| 3 |
BlackRock Fund Advisors |
816,211 |
7,362,000 |
5.75% |
|
|
| 4 |
GOLDMAN SACHS GROUP INC |
784,399 |
7,075,000 |
5.53% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
744,960 |
6,719,000 |
5.25% |
|
|
| 6 |
VANGUARD GROUP INC |
419,451 |
3,783,000 |
2.96% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
360,619 |
3,253,000 |
2.54% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
336,599 |
3,036,000 |
2.37% |
|
|
| 9 |
Abingworth LLP |
327,350 |
2,943,000 |
2.30% |
|
|
| 10 |
MARXE AUSTIN W & GREENHOUSE DAVID M |
225,000 |
2,029,000 |
1.59% |
|
|
| 11 |
BLACKROCK ADVISORS LLC |
220,731 |
1,991,000 |
1.56% |
|
|
| 12 |
Cormorant Asset Management, LP |
200,000 |
1,804,000 |
1.41% |
|
|
| 13 |
BVF INC/IL |
184,999 |
1,669,000 |
1.30% |
|
|
| 14 |
WELLS FARGO & COMPANY/MN |
167,015 |
1,507,000 |
1.18% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
136,574 |
1,232,000 |
0.96% |
|
|
| 16 |
NORTHERN TRUST CORP |
126,957 |
1,146,000 |
0.90% |
|
|
| 17 |
STATE STREET CORP |
121,839 |
1,098,000 |
0.86% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
115,000 |
1,037,000 |
0.81% |
|
|
| 19 |
Callan Capital, LLC |
80,478 |
726,000 |
0.57% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
79,572 |
717,000 |
0.56% |
|
|
| 21 |
PRUDENTIAL FINANCIAL INC |
70,800 |
639,000 |
0.50% |
|
|
| 22 |
Weiss Multi-Strategy Advisers LLC |
70,000 |
631,000 |
0.49% |
|
|
| 23 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
64,000 |
577,000 |
0.45% |
|
|
| 24 |
EMERALD MUTUAL FUND ADVISERS TRUST |
61,846 |
558,000 |
0.44% |
|
|
| 25 |
Bank of New York Mellon Corp |
58,613 |
529,000 |
0.41% |
|
|
| 26 |
ROYAL BANK OF CANADA |
47,300 |
427,000 |
0.33% |
|
|
| 27 |
ProShare Advisors LLC |
43,394 |
391,000 |
0.31% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
39,130 |
353,000 |
0.28% |
|
|
| 29 |
LPL Financial LLC |
37,000 |
334,000 |
0.26% |
|
|
| 30 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
43,400 |
333,000 |
0.26% |
|
|
| 31 |
BlackRock Investment Management, LLC |
28,322 |
255,000 |
0.20% |
|
|
| 32 |
Verity Asset Management, Inc. |
28,410 |
244,000 |
0.19% |
|
|
| 33 |
DekaBank Deutsche Girozentrale |
25,500 |
230,000 |
0.18% |
|
|
| 34 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
25,200 |
227,000 |
0.18% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
21,256 |
190,000 |
0.15% |
|
|
| 36 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
20,000 |
180,000 |
0.14% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,273 |
165,000 |
0.13% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
18,100 |
164,000 |
0.13% |
|
|
| 39 |
CREDIT SUISSE AG/ |
17,820 |
161,000 |
0.13% |
|
|
| 40 |
AMERICAN CENTURY COMPANIES INC |
15,693 |
142,000 |
0.11% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
14,093 |
127,000 |
0.10% |
|
|
| 42 |
LMR Partners LLP |
11,815 |
106,000 |
0.08% |
|
|
| 43 |
EMERALD ADVISERS, LLC |
11,157 |
101,000 |
0.08% |
|
|
| 44 |
BlackRock Japan Co. Ltd |
9,935 |
90,000 |
0.07% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,094 |
73,008 |
0.06% |
|
|
| 46 |
BARCLAYS PLC |
8,083 |
73,000 |
0.06% |
|
|
| 47 |
UBS AG |
8,000 |
72,000 |
0.06% |
|
|
| 48 |
Nationwide Fund Advisors |
8,023 |
72,000 |
0.06% |
|
|
| 49 |
Tower Research Capital LLC (TRC) |
6,126 |
55,000 |
0.04% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,373 |
48,000 |
0.04% |
|
|
