| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,317,134 | 50,790,000 | 44.24% | ||
| 2 | HealthCor Management, L.P. | 1,550,000 | 12,462,000 | 10.85% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 940,070 | 7,558,000 | 6.58% | ||
| 4 | BlackRock Fund Advisors | 849,286 | 6,828,000 | 5.95% | ||
| 5 | GOLDMAN SACHS GROUP INC | 791,207 | 6,361,000 | 5.54% | ||
| 6 | VANGUARD GROUP INC | 451,485 | 3,630,000 | 3.16% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 337,159 | 2,711,000 | 2.36% | ||
| 8 | Abingworth LLP | 327,350 | 2,625,000 | 2.29% | ||
| 9 | JENNISON ASSOCIATES LLC | 322,716 | 2,595,000 | 2.26% | ||
| 10 | MARXE AUSTIN W & GREENHOUSE DAVID M | 225,000 | 1,809,000 | 1.58% | ||
| 11 | BLACKROCK ADVISORS LLC | 221,027 | 1,777,000 | 1.55% | ||
| 12 | WELLS FARGO & COMPANY/MN | 207,970 | 1,673,000 | 1.46% | ||
| 13 | Cormorant Asset Management, LP | 200,000 | 1,608,000 | 1.40% | ||
| 14 | BVF INC/IL | 184,999 | 1,487,000 | 1.30% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 163,958 | 1,318,000 | 1.15% | ||
| 16 | NORTHERN TRUST CORP | 117,622 | 946,000 | 0.82% | ||
| 17 | STATE STREET CORP | 113,341 | 910,000 | 0.79% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 84,370 | 678,000 | 0.59% | ||
| 19 | ROYAL BANK OF CANADA | 83,923 | 675,000 | 0.59% | ||
| 20 | Callan Capital, LLC | 80,000 | 643,000 | 0.56% | ||
| 21 | Weiss Multi-Strategy Advisers LLC | 70,000 | 563,000 | 0.49% | ||
| 22 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 68,500 | 551,000 | 0.48% | ||
| 23 | Bank of New York Mellon Corp | 63,356 | 509,000 | 0.44% | ||
| 24 | PRUDENTIAL FINANCIAL INC | 62,800 | 505,000 | 0.44% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 47,984 | 386,000 | 0.34% | ||
| 26 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 47,600 | 383,000 | 0.33% | ||
| 27 | BlackRock Investment Management, LLC | 38,556 | 310,000 | 0.27% | ||
| 28 | ProShare Advisors LLC | 33,009 | 265,000 | 0.23% | ||
| 29 | Verity Asset Management, Inc. | 32,150 | 258,000 | 0.22% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,073 | 202,000 | 0.18% | ||
| 31 | DekaBank Deutsche Girozentrale | 25,000 | 201,000 | 0.18% | ||
| 32 | TEACHERS ADVISORS, LLC | 19,288 | 155,000 | 0.14% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,100 | 146,000 | 0.13% | ||
| 34 | LPL Financial LLC | 18,000 | 145,000 | 0.13% | ||
| 35 | DEUTSCHE BANK AG\ | 16,591 | 132,000 | 0.11% | ||
| 36 | CREDIT SUISSE AG/ | 14,978 | 120,000 | 0.10% | ||
| 37 | EMERALD ADVISERS, LLC | 12,874 | 104,000 | 0.09% | ||
| 38 | MORGAN STANLEY | 11,309 | 91,000 | 0.08% | ||
| 39 | RHUMBLINE ADVISERS | 10,927 | 88,000 | 0.08% | ||
| 40 | BARCLAYS PLC | 10,465 | 83,000 | 0.07% | ||
| 41 | Nationwide Fund Advisors | 10,258 | 82,000 | 0.07% | ||
| 42 | TFS CAPITAL LLC | 10,050 | 81,000 | 0.07% | ||
| 43 | UBS AG | 9,744 | 78,000 | 0.07% | ||
| 44 | BlackRock Japan Co. Ltd | 9,363 | 75,000 | 0.07% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 8,976 | 72,167 | 0.06% | ||
| 46 | Highlander Capital Management, LLC | 8,000 | 64,320 | 0.06% | ||
| 47 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 5,000 | 40,000 | 0.03% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,906 | 15,000 | 0.01% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 1,400 | 11,000 | 0.01% | ||
| 50 | VIRTUS CAPITAL ADVISERS, LLC | 1,170 | 9,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
