| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,508,851 | 44,455,000 | 44.65% | ||
| 2 | HealthCor Management, L.P. | 1,550,000 | 10,587,000 | 10.63% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,050,980 | 7,179,000 | 7.21% | ||
| 4 | BlackRock Fund Advisors | 852,959 | 5,826,000 | 5.85% | ||
| 5 | GOLDMAN SACHS GROUP INC | 761,761 | 5,203,000 | 5.23% | ||
| 6 | VANGUARD GROUP INC | 472,740 | 3,229,000 | 3.24% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 337,567 | 2,306,000 | 2.32% | ||
| 8 | Abingworth LLP | 327,350 | 2,242,000 | 2.25% | ||
| 9 | JENNISON ASSOCIATES LLC | 323,199 | 2,207,000 | 2.22% | ||
| 10 | MARXE AUSTIN W & GREENHOUSE DAVID M | 225,000 | 1,537,000 | 1.54% | ||
| 11 | Cormorant Asset Management, LP | 200,000 | 1,366,000 | 1.37% | ||
| 12 | BLACKROCK ADVISORS LLC | 197,966 | 1,352,000 | 1.36% | ||
| 13 | WELLS FARGO & COMPANY/MN | 187,277 | 1,279,000 | 1.28% | ||
| 14 | BVF INC/IL | 184,999 | 1,264,000 | 1.27% | ||
| 15 | NORTHERN TRUST CORP | 146,820 | 1,003,000 | 1.01% | ||
| 16 | SCHRODER INVESTMENT MANAGEMENT GROUP | 142,668 | 974,423 | 0.98% | ||
| 17 | STATE STREET CORP | 126,337 | 863,000 | 0.87% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 119,203 | 814,000 | 0.82% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 114,328 | 781,000 | 0.78% | ||
| 20 | ROYAL BANK OF CANADA | 99,223 | 678,000 | 0.68% | ||
| 21 | Callan Capital, LLC | 80,000 | 546,000 | 0.55% | ||
| 22 | Bank of New York Mellon Corp | 63,398 | 433,000 | 0.43% | ||
| 23 | PRUDENTIAL FINANCIAL INC | 61,900 | 423,000 | 0.42% | ||
| 24 | Weiss Multi-Strategy Advisers LLC | 60,000 | 410,000 | 0.41% | ||
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 47,600 | 325,000 | 0.33% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 46,165 | 315,000 | 0.32% | ||
| 27 | BlackRock Investment Management, LLC | 40,302 | 275,000 | 0.28% | ||
| 28 | Verity Asset Management, Inc. | 29,602 | 202,000 | 0.20% | ||
| 29 | ProShare Advisors LLC | 27,809 | 190,000 | 0.19% | ||
| 30 | DekaBank Deutsche Girozentrale | 25,500 | 174,000 | 0.17% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,217 | 172,000 | 0.17% | ||
| 32 | TEACHERS ADVISORS, LLC | 19,288 | 132,000 | 0.13% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,100 | 124,000 | 0.12% | ||
| 34 | LPL Financial LLC | 18,100 | 121,000 | 0.12% | ||
| 35 | DEUTSCHE BANK AG\ | 14,491 | 98,000 | 0.10% | ||
| 36 | RHUMBLINE ADVISERS | 10,927 | 75,000 | 0.08% | ||
| 37 | Nationwide Fund Advisors | 10,560 | 72,000 | 0.07% | ||
| 38 | MORGAN STANLEY | 10,441 | 72,000 | 0.07% | ||
| 39 | AMERICAN INTERNATIONAL GROUP, INC. | 8,970 | 61,265 | 0.06% | ||
| 40 | UBS AG | 8,000 | 55,000 | 0.06% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,042 | 34,000 | 0.03% | ||
| 42 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 5,000 | 34,000 | 0.03% | ||
| 43 | BARCLAYS PLC | 5,650 | 34,000 | 0.03% | ||
| 44 | Tower Research Capital LLC (TRC) | 2,340 | 16,000 | 0.02% | ||
| 45 | UBS AG | 1,600 | 11,000 | 0.01% | Call | |
| 46 | BNP PARIBAS FINANCIAL MARKETS | 1,095 | 7,479 | 0.01% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 700 | 5,000 | 0.01% | ||
| 48 | CITIGROUP INC | 691 | 4,000 | 0.00% | ||
| 49 | Ground Swell Capital, LLC | 416 | 3,000 | 0.00% | ||
| 50 | AMERIPRISE FINANCIAL INC | 200 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
