| 1 |
FMR LLC |
7,851,397 |
68,464,000 |
22.91% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
4,213,856 |
36,745,000 |
12.29% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
3,482,924 |
30,371,000 |
10.16% |
|
|
| 4 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
2,660,973 |
23,203,000 |
7.76% |
|
|
| 5 |
Capital World Investors |
2,015,000 |
17,571,000 |
5.88% |
|
|
| 6 |
Foresite Capital Management II, LLC |
1,750,669 |
15,266,000 |
5.11% |
|
|
| 7 |
BlackRock Fund Advisors |
1,372,711 |
11,970,000 |
4.00% |
|
|
| 8 |
VANGUARD GROUP INC |
1,104,290 |
9,629,000 |
3.22% |
|
|
| 9 |
AXA S.A. |
907,937 |
7,917,000 |
2.65% |
|
|
| 10 |
GOLDMAN SACHS GROUP INC |
745,805 |
6,503,000 |
2.18% |
|
|
| 11 |
FORESITE CAPITAL MANAGEMENT III, LLC |
718,997 |
6,270,000 |
2.10% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
699,572 |
6,100,000 |
2.04% |
|
|
| 13 |
COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT |
612,072 |
5,337,000 |
1.79% |
|
|
| 14 |
STATE STREET CORP |
344,677 |
3,006,000 |
1.01% |
|
|
| 15 |
Abingworth LLP |
327,350 |
2,851,000 |
0.95% |
|
|
| 16 |
NORTHERN TRUST CORP |
321,816 |
2,806,000 |
0.94% |
|
|
| 17 |
WELLS FARGO & COMPANY/MN |
272,652 |
2,378,000 |
0.80% |
|
|
| 18 |
OXFORD ASSET MANAGEMENT LLP |
260,798 |
2,335,000 |
0.78% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
227,600 |
1,985,000 |
0.66% |
|
|
| 20 |
SABBY MANAGEMENT, LLC |
210,000 |
1,831,000 |
0.61% |
|
|
| 21 |
ROYAL BANK OF CANADA |
209,754 |
1,829,000 |
0.61% |
|
|
| 22 |
Rhenman & Partners Asset Management AB |
200,000 |
1,744,000 |
0.58% |
|
|
| 23 |
South Dakota Investment Council |
187,630 |
1,636,000 |
0.55% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
182,526 |
1,591,000 |
0.53% |
|
|
| 25 |
EVENTIDE ASSET MANAGEMENT, LLC |
160,600 |
1,400,000 |
0.47% |
|
|
| 26 |
C WorldWide Group Holding A/S |
160,000 |
1,395,000 |
0.47% |
|
|
| 27 |
AMERIPRISE FINANCIAL INC |
143,931 |
1,255,000 |
0.42% |
|
|
| 28 |
CREDIT SUISSE AG/ |
143,371 |
1,250,000 |
0.42% |
|
|
| 29 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
137,250 |
1,197,000 |
0.40% |
|
|
| 30 |
Bank of New York Mellon Corp |
129,625 |
1,130,000 |
0.38% |
|
|
| 31 |
PRICE T ROWE ASSOCIATES INC /MD/ |
125,300 |
1,093,000 |
0.37% |
|
|
| 32 |
Trexquant Investment LP |
112,600 |
982,000 |
0.33% |
|
|
| 33 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
108,900 |
950,000 |
0.32% |
|
|
| 34 |
D. E. Shaw & Co., Inc. |
107,267 |
935,000 |
0.31% |
|
|
| 35 |
BlackRock Investment Management, LLC |
98,174 |
856,000 |
0.29% |
|
|
| 36 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
93,637 |
817,000 |
0.27% |
|
|
| 37 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
91,076 |
794,000 |
0.27% |
|
|
| 38 |
DAFNA Capital Management LLC |
90,000 |
785,000 |
0.26% |
|
|
| 39 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
81,378 |
710,000 |
0.24% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
69,951 |
608,000 |
0.20% |
|
|
| 41 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
69,510 |
606,000 |
0.20% |
|
|
| 42 |
ALPS ADVISORS INC |
68,954 |
601,000 |
0.20% |
|
|
| 43 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
56,207 |
490,000 |
0.16% |
|
|
| 44 |
Nationwide Fund Advisors |
53,984 |
471,000 |
0.16% |
|
|
| 45 |
MILLENNIUM MANAGEMENT LLC |
53,352 |
465,000 |
0.16% |
|
|
| 46 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
52,450 |
457,000 |
0.15% |
|
|
| 47 |
Trellus Management Company, LLC |
51,667 |
451,000 |
0.15% |
|
|
| 48 |
MACQUARIE GROUP LTD |
50,000 |
436,000 |
0.15% |
|
|
| 49 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
50,000 |
436,000 |
0.15% |
|
|
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
47,500 |
414,000 |
0.14% |
Call |
|
