| 1 |
FMR LLC |
7,787,929 |
50,933,000 |
22.03% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
4,217,986 |
27,586,000 |
11.93% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
4,039,823 |
26,420,000 |
11.43% |
|
|
| 4 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
2,213,064 |
14,474,000 |
6.26% |
|
|
| 5 |
Capital World Investors |
2,015,000 |
13,178,000 |
5.70% |
|
|
| 6 |
Foresite Capital Management II, LLC |
1,750,269 |
11,447,000 |
4.95% |
|
|
| 7 |
BlackRock Fund Advisors |
1,481,195 |
9,687,000 |
4.19% |
|
|
| 8 |
VANGUARD GROUP INC |
1,023,066 |
6,691,000 |
2.89% |
|
|
| 9 |
AXA S.A. |
927,022 |
6,063,000 |
2.62% |
|
|
| 10 |
Cormorant Asset Management, LP |
896,522 |
5,863,000 |
2.54% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
680,655 |
4,451,000 |
1.92% |
|
|
| 12 |
GOLDMAN SACHS GROUP INC |
680,496 |
4,450,000 |
1.92% |
|
|
| 13 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
382,331 |
2,500,000 |
1.08% |
|
|
| 14 |
ORACLE INVESTMENT MANAGEMENT INC |
374,532 |
2,449,000 |
1.06% |
|
|
| 15 |
SABBY MANAGEMENT, LLC |
356,504 |
2,332,000 |
1.01% |
|
|
| 16 |
Abingworth LLP |
327,350 |
2,138,000 |
0.92% |
|
|
| 17 |
STATE STREET CORP |
324,565 |
2,120,000 |
0.92% |
|
|
| 18 |
NORTHERN TRUST CORP |
309,289 |
2,022,000 |
0.87% |
|
|
| 19 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
301,700 |
1,973,000 |
0.85% |
Put |
|
| 20 |
C WorldWide Group Holding A/S |
300,000 |
1,962,000 |
0.85% |
|
|
| 21 |
WELLS FARGO & COMPANY/MN |
264,037 |
1,727,000 |
0.75% |
|
|
| 22 |
AMERIPRISE FINANCIAL INC |
260,655 |
1,704,000 |
0.74% |
|
|
| 23 |
Foresite Capital Management II, LLC |
250,000 |
1,635,000 |
0.71% |
Put |
|
| 24 |
Foresite Capital Management II, LLC |
250,000 |
1,635,000 |
0.71% |
Call |
|
| 25 |
South Dakota Investment Council |
240,330 |
1,572,000 |
0.68% |
|
|
| 26 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
227,600 |
1,489,000 |
0.64% |
|
|
| 27 |
Rhenman & Partners Asset Management AB |
200,000 |
1,308,000 |
0.57% |
|
|
| 28 |
ROYAL BANK OF CANADA |
195,311 |
1,276,000 |
0.55% |
|
|
| 29 |
COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT |
187,876 |
1,228,000 |
0.53% |
|
|
| 30 |
GEODE CAPITAL MANAGEMENT, LLC |
180,027 |
1,177,000 |
0.51% |
|
|
| 31 |
EVENTIDE ASSET MANAGEMENT, LLC |
160,516 |
1,050,000 |
0.45% |
|
|
| 32 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
140,950 |
922,000 |
0.40% |
|
|
| 33 |
CREDIT SUISSE AG/ |
134,545 |
879,000 |
0.38% |
|
|
| 34 |
PRICE T ROWE ASSOCIATES INC /MD/ |
119,700 |
783,000 |
0.34% |
|
|
| 35 |
Bank of New York Mellon Corp |
117,302 |
767,000 |
0.33% |
|
|
| 36 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
108,900 |
712,000 |
0.31% |
|
|
| 37 |
Trellus Management Company, LLC |
100,000 |
654,000 |
0.28% |
|
|
| 38 |
BlackRock Investment Management, LLC |
97,965 |
641,000 |
0.28% |
|
|
| 39 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
96,506 |
631,000 |
0.27% |
|
|
| 40 |
DAFNA Capital Management LLC |
90,000 |
589,000 |
0.25% |
|
|
| 41 |
WEDBUSH SECURITIES INC |
86,295 |
564,000 |
0.24% |
|
|
| 42 |
ARGONAUT CAPITAL MANAGEMENT CORP |
75,000 |
491,000 |
0.21% |
|
|
| 43 |
Amici Capital, LLC |
75,000 |
491,000 |
0.21% |
|
|
| 44 |
CITADEL ADVISORS LLC |
72,093 |
471,000 |
0.20% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
71,611 |
467,000 |
0.20% |
|
|
| 46 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
68,600 |
449,000 |
0.19% |
|
|
| 47 |
D. E. Shaw & Co., Inc. |
51,834 |
339,000 |
0.15% |
|
|
| 48 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
51,464 |
337,000 |
0.15% |
|
|
| 49 |
AQR CAPITAL MANAGEMENT LLC |
51,151 |
335,000 |
0.14% |
|
|
| 50 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
50,000 |
327,000 |
0.14% |
|
|
