| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,577,511 | 128,363,000 | 22.87% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,410,597 | 91,656,000 | 16.33% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 3,590,688 | 60,826,000 | 10.84% | ||
| 4 | Capital World Investors | 2,494,378 | 42,255,000 | 7.53% | ||
| 5 | STATE STREET CORP | 1,358,746 | 23,016,000 | 4.10% | ||
| 6 | ORACLE INVESTMENT MANAGEMENT INC | 1,287,150 | 21,804,000 | 3.88% | ||
| 7 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,097,438 | 18,591,000 | 3.31% | ||
| 8 | BlackRock Fund Advisors | 1,059,704 | 17,951,000 | 3.20% | ||
| 9 | Cormorant Asset Management, LP | 896,522 | 15,187,000 | 2.71% | ||
| 10 | VANGUARD GROUP INC | 846,660 | 14,342,000 | 2.56% | ||
| 11 | GOLDMAN SACHS GROUP INC | 802,961 | 13,602,000 | 2.42% | ||
| 12 | AMERIPRISE FINANCIAL INC | 790,424 | 13,390,000 | 2.39% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 486,856 | 8,247,000 | 1.47% | ||
| 14 | Foresite Capital Management II, LLC | 429,723 | 7,280,000 | 1.30% | ||
| 15 | JENNISON ASSOCIATES LLC | 403,351 | 6,833,000 | 1.22% | ||
| 16 | Abingworth LLP | 327,350 | 5,542,000 | 0.99% | ||
| 17 | SABBY MANAGEMENT, LLC | 260,930 | 4,420,000 | 0.79% | ||
| 18 | GUGGENHEIM CAPITAL LLC | 219,573 | 3,720,000 | 0.66% | ||
| 19 | NORTHERN TRUST CORP | 208,627 | 3,534,000 | 0.63% | ||
| 20 | LORD, ABBETT & CO. LLC | 198,318 | 3,360,000 | 0.60% | ||
| 21 | ROYAL BANK OF CANADA | 193,851 | 3,284,000 | 0.59% | ||
| 22 | WELLS FARGO & COMPANY/MN | 182,689 | 3,094,000 | 0.55% | ||
| 23 | CREDIT SUISSE AG/ | 175,320 | 2,969,000 | 0.53% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 146,755 | 2,486,000 | 0.44% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 145,100 | 2,458,000 | 0.44% | Call | |
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 131,200 | 2,223,000 | 0.40% | Put | |
| 27 | AWM Investment Company, Inc. | 125,000 | 2,117,000 | 0.38% | ||
| 28 | DRIEHAUS CAPITAL MANAGEMENT LLC | 119,848 | 2,030,000 | 0.36% | ||
| 29 | EVENTIDE ASSET MANAGEMENT, LLC | 116,000 | 1,965,000 | 0.35% | ||
| 30 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 108,900 | 1,845,000 | 0.33% | ||
| 31 | DEUTSCHE BANK AG\ | 104,647 | 1,771,000 | 0.32% | ||
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 97,200 | 1,647,000 | 0.29% | ||
| 33 | GROUP ONE TRADING LLC | 94,750 | 1,605,000 | 0.29% | ||
| 34 | Invesco Ltd. | 85,422 | 1,447,000 | 0.26% | ||
| 35 | MACQUARIE GROUP LTD | 83,597 | 1,416,000 | 0.25% | ||
| 36 | Bank of New York Mellon Corp | 73,344 | 1,242,000 | 0.22% | ||
| 37 | South Dakota Investment Council | 71,033 | 1,203,000 | 0.21% | ||
| 38 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 70,260 | 1,190,000 | 0.21% | ||
| 39 | A.R.T. Advisors, LLC | 60,563 | 1,025,000 | 0.18% | ||
| 40 | HAP Trading, LLC | 300,300 | 927,000 | 0.17% | Call | |
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 47,600 | 900,000 | 0.16% | ||
| 42 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 847,000 | 0.15% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,334 | 836,000 | 0.15% | ||
| 44 | AQR CAPITAL MANAGEMENT LLC | 48,500 | 822,000 | 0.15% | ||
| 45 | HBK INVESTMENTS L P | 48,218 | 817,000 | 0.15% | ||
| 46 | WEDBUSH SECURITIES INC | 46,205 | 783,000 | 0.14% | ||
| 47 | CITADEL ADVISORS LLC | 45,812 | 776,000 | 0.14% | ||
| 48 | BlackRock Investment Management, LLC | 44,567 | 755,000 | 0.13% | ||
| 49 | ProShare Advisors LLC | 43,671 | 740,000 | 0.13% | ||
| 50 | PRUDENTIAL FINANCIAL INC | 41,500 | 703,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
