| 1 |
FMR LLC |
7,905,717 |
54,787,000 |
23.01% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
4,031,571 |
27,938,000 |
11.73% |
|
|
| 3 |
Capital World Investors |
3,535,000 |
24,498,000 |
10.29% |
|
|
| 4 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
2,686,108 |
18,615,000 |
7.82% |
|
|
| 5 |
Foresite Capital Management II, LLC |
2,038,939 |
14,130,000 |
5.93% |
|
|
| 6 |
BlackRock Fund Advisors |
1,423,233 |
9,863,000 |
4.14% |
|
|
| 7 |
VANGUARD GROUP INC |
1,175,887 |
8,149,000 |
3.42% |
|
|
| 8 |
RA CAPITAL MANAGEMENT, L.P. |
1,045,119 |
7,243,000 |
3.04% |
|
|
| 9 |
AXA S.A. |
893,502 |
6,192,000 |
2.60% |
|
|
| 10 |
FORESITE CAPITAL MANAGEMENT III, LLC |
789,091 |
5,468,000 |
2.30% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
774,070 |
5,364,000 |
2.25% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
693,499 |
4,806,000 |
2.02% |
|
|
| 13 |
OXFORD ASSET MANAGEMENT LLP |
544,332 |
3,772,000 |
1.58% |
|
|
| 14 |
COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT |
498,719 |
3,456,000 |
1.45% |
|
|
| 15 |
WELLS FARGO & COMPANY/MN |
407,724 |
2,826,000 |
1.19% |
|
|
| 16 |
DAFNA Capital Management LLC |
391,500 |
2,713,000 |
1.14% |
|
|
| 17 |
STATE STREET CORP |
377,896 |
2,618,000 |
1.10% |
|
|
| 18 |
Abingworth LLP |
327,350 |
2,265,000 |
0.95% |
|
|
| 19 |
PERCEPTIVE ADVISORS LLC |
325,407 |
2,256,000 |
0.95% |
|
|
| 20 |
NORTHERN TRUST CORP |
323,421 |
2,241,000 |
0.94% |
|
|
| 21 |
ROYAL BANK OF CANADA |
222,004 |
1,538,000 |
0.65% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
214,600 |
1,487,000 |
0.62% |
|
|
| 23 |
Rhenman & Partners Asset Management AB |
200,000 |
1,386,000 |
0.58% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
186,675 |
1,294,000 |
0.54% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
183,740 |
1,273,000 |
0.53% |
|
|
| 26 |
AMERIPRISE FINANCIAL INC |
158,977 |
1,103,000 |
0.46% |
|
|
| 27 |
CREDIT SUISSE AG/ |
141,773 |
982,000 |
0.41% |
|
|
| 28 |
SABBY MANAGEMENT, LLC |
140,000 |
970,000 |
0.41% |
|
|
| 29 |
GLOBEFLEX CAPITAL L P |
138,810 |
962,000 |
0.40% |
|
|
| 30 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
133,450 |
925,000 |
0.39% |
|
|
| 31 |
South Dakota Investment Council |
126,870 |
879,000 |
0.37% |
|
|
| 32 |
Bank of New York Mellon Corp |
121,098 |
839,000 |
0.35% |
|
|
| 33 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
108,900 |
755,000 |
0.32% |
|
|
| 34 |
PRICE T ROWE ASSOCIATES INC /MD/ |
107,300 |
744,000 |
0.31% |
|
|
| 35 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
109,987 |
720,000 |
0.30% |
|
|
| 36 |
BlackRock Investment Management, LLC |
99,830 |
692,000 |
0.29% |
|
|
| 37 |
MARSHALL WACE, LLP |
98,471 |
682,000 |
0.29% |
|
|
| 38 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
91,076 |
631,000 |
0.27% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
72,848 |
503,000 |
0.21% |
|
|
| 40 |
D. E. Shaw & Co., Inc. |
68,682 |
476,000 |
0.20% |
|
|
| 41 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
59,890 |
415,000 |
0.17% |
|
|
| 42 |
ALPS ADVISORS INC |
59,273 |
411,000 |
0.17% |
|
|
| 43 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
58,000 |
402,000 |
0.17% |
Call |
|
| 44 |
Nationwide Fund Advisors |
54,973 |
381,000 |
0.16% |
|
|
| 45 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
54,500 |
378,000 |
0.16% |
Put |
|
| 46 |
Swiss National Bank |
53,300 |
358,000 |
0.15% |
|
|
| 47 |
MACQUARIE GROUP LTD |
50,000 |
347,000 |
0.15% |
|
|
| 48 |
Trexquant Investment LP |
49,694 |
344,000 |
0.14% |
|
|
| 49 |
GROUP ONE TRADING LLC |
44,087 |
306,000 |
0.13% |
|
|
| 50 |
TEACHERS ADVISORS, LLC |
43,743 |
303,000 |
0.13% |
|
|
