| 1 |
FMR LLC |
7,652,610 |
83,873,000 |
22.00% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
4,853,442 |
53,194,000 |
13.95% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
3,790,476 |
41,544,000 |
10.89% |
|
|
| 4 |
STATE STREET CORP |
2,659,285 |
29,145,000 |
7.64% |
|
|
| 5 |
Capital World Investors |
2,015,000 |
22,084,000 |
5.79% |
|
|
| 6 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
1,461,743 |
16,020,000 |
4.20% |
|
|
| 7 |
BlackRock Fund Advisors |
1,408,287 |
15,435,000 |
4.05% |
|
|
| 8 |
VANGUARD GROUP INC |
902,252 |
9,889,000 |
2.59% |
|
|
| 9 |
Cormorant Asset Management, LP |
896,522 |
9,826,000 |
2.58% |
|
|
| 10 |
Foresite Capital Management II, LLC |
893,781 |
9,796,000 |
2.57% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
816,954 |
8,954,000 |
2.35% |
|
|
| 12 |
ORACLE INVESTMENT MANAGEMENT INC |
741,804 |
8,130,000 |
2.13% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
602,295 |
6,601,000 |
1.73% |
|
|
| 14 |
JENNISON ASSOCIATES LLC |
407,409 |
4,465,000 |
1.17% |
|
|
| 15 |
SABBY MANAGEMENT, LLC |
344,667 |
3,778,000 |
0.99% |
|
|
| 16 |
Abingworth LLP |
327,350 |
3,588,000 |
0.94% |
|
|
| 17 |
AMERIPRISE FINANCIAL INC |
291,890 |
3,198,000 |
0.84% |
|
|
| 18 |
CREDIT SUISSE AG/ |
259,739 |
2,848,000 |
0.75% |
|
|
| 19 |
WELLS FARGO & COMPANY/MN |
250,188 |
2,742,000 |
0.72% |
|
|
| 20 |
South Dakota Investment Council |
240,330 |
2,634,000 |
0.69% |
|
|
| 21 |
ROYAL BANK OF CANADA |
205,751 |
2,255,000 |
0.59% |
|
|
| 22 |
PERCEPTIVE ADVISORS LLC |
200,000 |
2,196,000 |
0.58% |
Put |
|
| 23 |
NORTHERN TRUST CORP |
192,212 |
2,106,000 |
0.55% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
162,491 |
1,780,000 |
0.47% |
|
|
| 25 |
EVENTIDE ASSET MANAGEMENT, LLC |
160,516 |
1,759,000 |
0.46% |
|
|
| 26 |
Bank of New York Mellon Corp |
140,704 |
1,542,000 |
0.40% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
140,299 |
1,535,000 |
0.40% |
|
|
| 28 |
C WorldWide Group Holding A/S |
140,000 |
1,534,000 |
0.40% |
|
|
| 29 |
PRICE T ROWE ASSOCIATES INC /MD/ |
117,900 |
1,292,000 |
0.34% |
|
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
117,570 |
1,289,000 |
0.34% |
|
|
| 31 |
MACQUARIE GROUP LTD |
110,413 |
1,210,000 |
0.32% |
|
|
| 32 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
108,900 |
1,194,000 |
0.31% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
103,000 |
1,129,000 |
0.30% |
Put |
|
| 34 |
BlackRock Investment Management, LLC |
100,312 |
1,099,000 |
0.29% |
|
|
| 35 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
96,506 |
1,058,000 |
0.28% |
|
|
| 36 |
WEDBUSH SECURITIES INC |
93,165 |
1,021,000 |
0.27% |
|
|
| 37 |
Trellus Management Company, LLC |
80,000 |
877,000 |
0.23% |
|
|
| 38 |
Laurion Capital Management LP |
75,417 |
827,000 |
0.22% |
|
|
| 39 |
Amici Capital, LLC |
75,000 |
822,000 |
0.22% |
|
|
| 40 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
71,920 |
788,000 |
0.21% |
|
|
| 41 |
AQR CAPITAL MANAGEMENT LLC |
71,471 |
783,000 |
0.21% |
|
|
| 42 |
GROUP ONE TRADING LLC |
64,613 |
708,000 |
0.19% |
|
|
| 43 |
RENAISSANCE TECHNOLOGIES LLC |
57,000 |
625,000 |
0.16% |
|
|
| 44 |
Numeric Investors LLC |
55,200 |
605,000 |
0.16% |
|
|
| 45 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
54,000 |
592,000 |
0.16% |
Call |
|
| 46 |
AWM Investment Company, Inc. |
52,100 |
571,000 |
0.15% |
|
|
| 47 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
51,664 |
566,000 |
0.15% |
|
|
| 48 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
50,000 |
548,000 |
0.14% |
|
|
| 49 |
BANK OF AMERICA CORP /DE/ |
49,274 |
540,000 |
0.14% |
|
|
| 50 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
47,600 |
522,000 |
0.14% |
|
|
