| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,290,574 | 116,941,000 | 23.53% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 4,742,911 | 76,076,000 | 15.31% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 3,779,174 | 60,618,000 | 12.20% | ||
| 4 | Capital World Investors | 2,448,400 | 46,887,000 | 9.43% | ||
| 5 | STATE STREET CORP | 1,219,814 | 19,566,000 | 3.94% | ||
| 6 | Cormorant Asset Management, LP | 1,100,000 | 17,644,000 | 3.55% | ||
| 7 | BlackRock Fund Advisors | 998,306 | 16,013,000 | 3.22% | ||
| 8 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 968,816 | 15,538,000 | 3.13% | ||
| 9 | AMERIPRISE FINANCIAL INC | 838,403 | 13,447,000 | 2.71% | ||
| 10 | VANGUARD GROUP INC | 763,562 | 12,247,000 | 2.46% | ||
| 11 | GOLDMAN SACHS GROUP INC | 550,024 | 8,822,000 | 1.78% | ||
| 12 | JENNISON ASSOCIATES LLC | 402,075 | 6,449,000 | 1.30% | ||
| 13 | ORBIMED ADVISORS LLC | 400,000 | 6,416,000 | 1.29% | ||
| 14 | SABBY MANAGEMENT, LLC | 352,278 | 5,651,000 | 1.14% | ||
| 15 | Abingworth LLP | 327,350 | 5,247,000 | 1.06% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 319,113 | 5,119,000 | 1.03% | ||
| 17 | ROYAL LONDON ASSET MANAGEMENT LTD | 30,000 | 4,815,000 | 0.97% | ||
| 18 | Candriam S.C.A. | 200,000 | 3,208,000 | 0.65% | ||
| 19 | GUGGENHEIM CAPITAL LLC | 187,555 | 3,008,000 | 0.61% | ||
| 20 | WELLS FARGO & COMPANY/MN | 172,345 | 2,764,000 | 0.56% | ||
| 21 | NORTHERN TRUST CORP | 170,334 | 2,732,000 | 0.55% | ||
| 22 | LORD, ABBETT & CO. LLC | 169,864 | 2,725,000 | 0.55% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 158,500 | 2,542,000 | 0.51% | Call | |
| 24 | AWM Investment Company, Inc. | 152,100 | 2,440,000 | 0.49% | ||
| 25 | CREDIT SUISSE AG/ | 148,143 | 2,377,000 | 0.48% | ||
| 26 | ROYAL BANK OF CANADA | 144,274 | 2,314,000 | 0.47% | ||
| 27 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 144,200 | 2,313,000 | 0.47% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 141,632 | 2,271,000 | 0.46% | ||
| 29 | Tourbillon Capital Partners, L.P. | 100,000 | 1,604,000 | 0.32% | Put | |
| 30 | UBS Group AG | 90,000 | 1,444,000 | 0.29% | Put | |
| 31 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 80,000 | 1,283,000 | 0.26% | ||
| 32 | Callan Capital, LLC | 80,000 | 1,283,000 | 0.26% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,800 | 1,232,000 | 0.25% | Put | |
| 34 | Bank of New York Mellon Corp | 72,971 | 1,170,000 | 0.24% | ||
| 35 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 68,310 | 1,096,000 | 0.22% | ||
| 36 | SCHRODER INVESTMENT MANAGEMENT GROUP | 66,594 | 1,068,000 | 0.21% | ||
| 37 | RUSSELL FRANK CO/ | 62,844 | 1,008,000 | 0.20% | ||
| 38 | DEUTSCHE BANK AG\ | 62,359 | 999,000 | 0.20% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 60,000 | 962,000 | 0.19% | ||
| 40 | Informed Momentum Co LLC | 59,887 | 961,000 | 0.19% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 47,600 | 900,000 | 0.18% | ||
| 42 | GROUP ONE TRADING LLC | 53,901 | 865,000 | 0.17% | ||
| 43 | PRUDENTIAL FINANCIAL INC | 51,200 | 821,000 | 0.17% | ||
| 44 | ARROWGRASS CAPITAL PARTNERS (US) LP | 50,000 | 802,000 | 0.16% | ||
| 45 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 802,000 | 0.16% | ||
| 46 | Numeric Investors LLC | 47,200 | 757,000 | 0.15% | ||
| 47 | BlackRock Investment Management, LLC | 43,651 | 700,000 | 0.14% | ||
| 48 | HAP Trading, LLC | 43,055 | 691,000 | 0.14% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,609 | 683,000 | 0.14% | ||
| 50 | HAP Trading, LLC | 300,000 | 682,000 | 0.14% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
