| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,335,735 | 60,691,000 | 16.74% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 13,843,629 | 45,823,000 | 12.64% | ||
| 3 | BlackRock Finance, Inc. | 10,164,146 | 33,644,000 | 9.28% | ||
| 4 | GREAT POINT PARTNERS LLC | 9,105,691 | 30,140,000 | 8.31% | ||
| 5 | VANGUARD GROUP INC | 5,691,035 | 18,837,000 | 5.19% | ||
| 6 | OppenheimerFunds, Inc. | 5,001,566 | 16,555,000 | 4.56% | ||
| 7 | Palo Alto Investors LP | 4,254,623 | 14,083,000 | 3.88% | ||
| 8 | NEA Management Company, LLC | 3,243,150 | 10,375,000 | 2.86% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 3,038,693 | 10,058,000 | 2.77% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,753,833 | 9,115,000 | 2.51% | ||
| 11 | BAKER BROS. ADVISORS LP | 2,518,882 | 8,337,000 | 2.30% | ||
| 12 | STATE STREET CORP | 2,098,357 | 6,947,000 | 1.92% | ||
| 13 | Cormorant Asset Management, LP | 2,000,000 | 6,620,000 | 1.83% | ||
| 14 | Sio Capital Management, LLC | 1,888,181 | 6,250,000 | 1.72% | ||
| 15 | MARSHALL WACE ASIA LTD | 1,978,326 | 5,935,000 | 1.64% | ||
| 16 | MARSHALL WACE NORTH AMERICA, L.P. | 1,978,326 | 5,935,000 | 1.64% | ||
| 17 | D. E. Shaw & Co., Inc. | 1,618,648 | 5,358,000 | 1.48% | ||
| 18 | JPMORGAN CHASE & CO | 1,449,714 | 4,799,000 | 1.32% | ||
| 19 | NORTHERN TRUST CORP | 1,361,376 | 4,506,000 | 1.24% | ||
| 20 | Rhenman & Partners Asset Management AB | 1,282,000 | 4,243,000 | 1.17% | ||
| 21 | Ghost Tree Capital, LLC | 1,100,000 | 3,641,000 | 1.00% | ||
| 22 | Candriam S.C.A. | 1,085,000 | 3,592,000 | 0.99% | ||
| 23 | DIMENSIONAL FUND ADVISORS LP | 1,023,098 | 3,386,000 | 0.93% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 1,012,241 | 3,350,000 | 0.92% | ||
| 25 | Rock Springs Capital Management LP | 1,000,000 | 3,310,000 | 0.91% | ||
| 26 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 881,500 | 2,918,000 | 0.80% | ||
| 27 | State of New Jersey Common Pension Fund D | 850,000 | 2,814,000 | 0.78% | ||
| 28 | Bank of New York Mellon Corp | 578,414 | 1,915,000 | 0.53% | ||
| 29 | PAULSON & CO. INC. | 550,000 | 1,821,000 | 0.50% | ||
| 30 | MACQUARIE GROUP LTD | 532,208 | 1,762,000 | 0.49% | ||
| 31 | J. Goldman & Co LP | 494,000 | 1,635,000 | 0.45% | ||
| 32 | DEUTSCHE BANK AG\ | 474,253 | 1,567,000 | 0.43% | ||
| 33 | DAFNA Capital Management LLC | 473,478 | 1,567,000 | 0.43% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 450,545 | 1,491,000 | 0.41% | ||
| 35 | Alyeska Investment Group, L.P. | 400,280 | 1,325,000 | 0.37% | ||
| 36 | NJ State Employees Deferred Compensation Plan | 355,000 | 1,175,000 | 0.32% | ||
| 37 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 308,695 | 1,022,000 | 0.28% | ||
| 38 | MORGAN STANLEY | 300,489 | 994,000 | 0.27% | ||
| 39 | TEACHERS ADVISORS, LLC | 278,553 | 922,000 | 0.25% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 268,000 | 888,000 | 0.24% | ||
| 41 | CREDIT SUISSE AG/ | 246,476 | 816,000 | 0.23% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 242,683 | 803,000 | 0.22% | ||
| 43 | Connor, Clark & Lunn Investment Management Ltd. | 212,651 | 704,000 | 0.19% | ||
| 44 | Nationwide Fund Advisors | 206,304 | 683,000 | 0.19% | ||
| 45 | GOLDMAN SACHS GROUP INC | 191,001 | 632,000 | 0.17% | ||
| 46 | Telemetry Investments, L.L.C. | 170,000 | 563,000 | 0.16% | ||
| 47 | CITADEL ADVISORS LLC | 170,091 | 563,000 | 0.16% | ||
| 48 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 157,800 | 522,000 | 0.14% | ||
| 49 | Hudson Bay Capital Management LP | 150,000 | 497,000 | 0.14% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 144,401 | 478,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
