| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 3,412,857 | 45,289,000 | 24.59% | ||
| 2 | FMR LLC | 2,512,824 | 33,345,000 | 18.11% | ||
| 3 | ORBIMED ADVISORS LLC | 2,191,000 | 29,075,000 | 15.79% | ||
| 4 | VIVO CAPITAL, LLC | 1,766,832 | 23,446,000 | 12.73% | ||
| 5 | BAKER BROS. ADVISORS LP | 745,521 | 9,893,000 | 5.37% | ||
| 6 | VHCP MANAGEMENT II, LLC | 721,152 | 9,570,000 | 5.20% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 662,894 | 8,797,000 | 4.78% | ||
| 8 | ACUTA CAPITAL PARTNERS, LLC | 472,800 | 6,274,000 | 3.41% | ||
| 9 | Rock Springs Capital Management LP | 300,000 | 3,981,000 | 2.16% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 261,800 | 3,474,000 | 1.89% | ||
| 11 | Sio Capital Management, LLC | 202,520 | 2,687,000 | 1.46% | ||
| 12 | Sculptor Capital LP | 149,900 | 1,990,000 | 1.08% | ||
| 13 | Ghost Tree Capital, LLC | 100,000 | 1,327,000 | 0.72% | ||
| 14 | VHCP Management, LLC | 90,000 | 1,194,000 | 0.65% | ||
| 15 | GREAT POINT PARTNERS LLC | 76,511 | 1,015,000 | 0.55% | ||
| 16 | Cormorant Asset Management, LP | 62,254 | 826,000 | 0.45% | ||
| 17 | DAFNA Capital Management LLC | 53,241 | 707,000 | 0.38% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 51,256 | 680,000 | 0.37% | ||
| 19 | CREDIT SUISSE AG/ | 16,030 | 212,000 | 0.12% | ||
| 20 | GSA CAPITAL PARTNERS LLP | 13,100 | 174,000 | 0.09% | ||
| 21 | Quantitative Systematic Strategies LLC | 11,925 | 162,000 | 0.09% | ||
| 22 | Tower Research Capital LLC (TRC) | 1,599 | 21,000 | 0.01% | ||
| 23 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 608 | 8,000 | 0.00% | ||
| 24 | WOLVERINE TRADING LP /BD | 16 | 217 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
