| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Palo Alto Investors LP | 4,203,270 | 58,846,000 | 10.57% | ||
| 2 | BlackRock Finance, Inc. | 3,853,200 | 53,944,000 | 9.69% | ||
| 3 | VANGUARD GROUP INC | 2,494,347 | 34,920,000 | 6.27% | ||
| 4 | Point72 Asset Management, L.P. | 2,484,500 | 34,783,000 | 6.25% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,299,046 | 32,187,000 | 5.78% | ||
| 6 | GREAT POINT PARTNERS LLC | 2,232,238 | 31,251,000 | 5.61% | ||
| 7 | ARMISTICE CAPITAL, LLC | 1,608,000 | 22,512,000 | 4.04% | ||
| 8 | FMR LLC | 1,601,171 | 22,416,000 | 4.03% | ||
| 9 | MORGAN STANLEY | 1,594,496 | 22,323,000 | 4.01% | ||
| 10 | STATE STREET CORP | 1,572,186 | 22,007,000 | 3.95% | ||
| 11 | MACQUARIE GROUP LTD | 1,565,281 | 21,914,000 | 3.94% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 939,250 | 13,150,000 | 2.36% | ||
| 13 | Avoro Capital Advisors LLC | 617,200 | 8,641,000 | 1.55% | ||
| 14 | PRUDENTIAL FINANCIAL INC | 614,318 | 8,600,000 | 1.54% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 569,343 | 7,971,000 | 1.43% | ||
| 16 | ACADIAN ASSET MANAGEMENT LLC | 550,306 | 7,703,000 | 1.38% | ||
| 17 | TEACHERS ADVISORS, LLC | 535,861 | 7,502,000 | 1.35% | ||
| 18 | NORTHERN TRUST CORP | 513,094 | 7,183,000 | 1.29% | ||
| 19 | NEXTHERA CAPITAL LP | 512,200 | 7,171,000 | 1.29% | ||
| 20 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 444,686 | 6,226,000 | 1.12% | ||
| 21 | CITADEL ADVISORS LLC | 444,685 | 6,225,000 | 1.12% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 412,524 | 5,775,000 | 1.04% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 408,952 | 5,725,000 | 1.03% | ||
| 24 | QS Investors, LLC | 349,621 | 4,895,000 | 0.88% | ||
| 25 | GOLDMAN SACHS GROUP INC | 328,868 | 4,604,000 | 0.83% | ||
| 26 | PNC FINANCIAL SERVICES GROUP, INC. | 313,802 | 4,393,000 | 0.79% | ||
| 27 | D. E. Shaw & Co., Inc. | 308,112 | 4,313,000 | 0.77% | ||
| 28 | DEUTSCHE BANK AG\ | 302,489 | 4,233,000 | 0.76% | ||
| 29 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 288,392 | 4,037,000 | 0.72% | ||
| 30 | AJO, LP | 279,094 | 3,907,000 | 0.70% | ||
| 31 | Candriam S.C.A. | 237,000 | 3,318,000 | 0.60% | ||
| 32 | CREDIT SUISSE AG/ | 213,808 | 2,993,000 | 0.54% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 212,275 | 2,972,000 | 0.53% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 199,602 | 2,794,000 | 0.50% | ||
| 35 | Spark Investment Management LLC | 198,500 | 2,779,000 | 0.50% | ||
| 36 | Bank of New York Mellon Corp | 185,942 | 2,603,000 | 0.47% | ||
| 37 | UNIVERSITY OF NOTRE DAME DU LAC | 176,056 | 2,465,000 | 0.44% | ||
| 38 | Gotham Asset Management, LLC | 167,953 | 2,351,000 | 0.42% | ||
| 39 | Numeric Investors LLC | 143,200 | 2,005,000 | 0.36% | ||
| 40 | JPMORGAN CHASE & CO | 142,051 | 1,989,000 | 0.36% | ||
| 41 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 135,817 | 1,895,000 | 0.34% | ||
| 42 | SECOR Capital Advisors, LP | 133,921 | 1,875,000 | 0.34% | ||
| 43 | Allianz Asset Management GmbH | 129,486 | 1,813,000 | 0.33% | ||
| 44 | AXIOM INVESTORS LLC /DE | 129,356 | 1,811,000 | 0.33% | ||
| 45 | WELLS FARGO & COMPANY/MN | 118,364 | 1,658,000 | 0.30% | ||
| 46 | TWO SIGMA ADVISERS, LP | 114,300 | 1,600,000 | 0.29% | ||
| 47 | PDT Partners, LLC | 108,860 | 1,524,000 | 0.27% | ||
| 48 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 107,768 | 1,509,000 | 0.27% | ||
| 49 | WELLINGTON MANAGEMENT GROUP LLP | 107,313 | 1,502,000 | 0.27% | ||
| 50 | PANAGORA ASSET MANAGEMENT INC | 107,124 | 1,500,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
