| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,652,097 | 37,024,000 | 39.81% | ||
| 2 | Redmile Group, LLC | 648,879 | 9,058,000 | 9.74% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 460,860 | 6,434,000 | 6.92% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 395,400 | 5,520,000 | 5.94% | ||
| 5 | BLACKROCK ADVISORS LLC | 287,647 | 4,015,000 | 4.32% | ||
| 6 | AXA S.A. | 207,046 | 2,890,000 | 3.11% | ||
| 7 | VANGUARD GROUP INC | 197,200 | 2,753,000 | 2.96% | ||
| 8 | BlackRock Group LTD | 181,112 | 2,529,000 | 2.72% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 175,547 | 2,451,000 | 2.64% | ||
| 10 | BlackRock Fund Advisors | 169,793 | 2,370,000 | 2.55% | ||
| 11 | PRINCIPAL FINANCIAL GROUP INC | 150,000 | 2,094,000 | 2.25% | ||
| 12 | BVF INC/IL | 125,000 | 1,745,000 | 1.88% | ||
| 13 | PUTNAM INVESTMENTS LLC | 123,527 | 1,724,000 | 1.85% | ||
| 14 | BAKER BROS. ADVISORS LP | 100,000 | 1,396,000 | 1.50% | ||
| 15 | Iguana Healthcare Management, LLC | 75,000 | 1,047,000 | 1.13% | ||
| 16 | STATE STREET CORP | 74,127 | 1,036,000 | 1.11% | ||
| 17 | JPMORGAN CHASE & CO | 73,305 | 1,023,000 | 1.10% | ||
| 18 | Hutchin Hill Capital, LP | 65,395 | 913,000 | 0.98% | ||
| 19 | MAZAMA CAPITAL MANAGEMENT INC | 61,631 | 860,000 | 0.92% | ||
| 20 | BlackRock Finance, Inc. | 61,121 | 853,000 | 0.92% | ||
| 21 | PERCEPTIVE ADVISORS LLC | 60,000 | 838,000 | 0.90% | ||
| 22 | GABELLI FUNDS LLC | 29,200 | 408,000 | 0.44% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 28,879 | 403,000 | 0.43% | ||
| 24 | NORTHERN TRUST CORP | 26,840 | 375,000 | 0.40% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 24,391 | 340,000 | 0.37% | ||
| 26 | MORGAN STANLEY | 23,930 | 334,000 | 0.36% | ||
| 27 | Bank of New York Mellon Corp | 21,863 | 306,000 | 0.33% | ||
| 28 | BlackRock Investment Management, LLC | 19,112 | 267,000 | 0.29% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,445 | 230,000 | 0.25% | ||
| 30 | TD ASSET MANAGEMENT INC | 16,500 | 230,000 | 0.25% | ||
| 31 | TFS CAPITAL LLC | 14,670 | 205,000 | 0.22% | ||
| 32 | Alyeska Investment Group, L.P. | 14,049 | 196,000 | 0.21% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,600 | 176,000 | 0.19% | ||
| 34 | BANQUE PICTET & CIE SA | 10,930 | 153,000 | 0.16% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,100 | 141,000 | 0.15% | ||
| 36 | Nationwide Fund Advisors | 9,435 | 132,000 | 0.14% | ||
| 37 | TEACHERS ADVISORS, LLC | 9,454 | 132,000 | 0.14% | ||
| 38 | PANAGORA ASSET MANAGEMENT INC | 8,956 | 125,000 | 0.13% | ||
| 39 | Tower Research Capital LLC (TRC) | 5,340 | 75,000 | 0.08% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 4,514 | 63,015 | 0.07% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 3,459 | 48,000 | 0.05% | ||
| 42 | DEUTSCHE BANK AG\ | 2,949 | 40,000 | 0.04% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 1,800 | 25,000 | 0.03% | ||
| 44 | WELLS FARGO & COMPANY/MN | 991 | 14,000 | 0.02% | ||
| 45 | VIRTUS CAPITAL ADVISERS, LLC | 588 | 8,000 | 0.01% | ||
| 46 | BARCLAYS PLC | 151 | 2,000 | 0.00% | ||
| 47 | PNC FINANCIAL SERVICES GROUP, INC. | 120 | 2,000 | 0.00% | ||
| 48 | CITIGROUP INC | 59 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
