| 1 |
FMR LLC |
2,652,097 |
15,992,000 |
28.98% |
|
|
| 2 |
WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST |
1,350,000 |
8,141,000 |
14.75% |
|
|
| 3 |
Versant Venture Management, LLC |
1,281,152 |
7,725,346 |
14.00% |
|
|
| 4 |
MAZAMA CAPITAL MANAGEMENT INC |
923,345 |
5,568,000 |
10.09% |
|
|
| 5 |
AXA S.A. |
402,464 |
2,427,000 |
4.40% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
329,089 |
1,984,000 |
3.59% |
|
|
| 7 |
Point72 Asset Management, L.P. |
242,039 |
1,459,000 |
2.64% |
|
|
| 8 |
VANGUARD GROUP INC |
238,002 |
1,435,000 |
2.60% |
|
|
| 9 |
Omega Fund Management, LLC |
166,450 |
1,004,000 |
1.82% |
|
|
| 10 |
New Leaf Venture Partners, L.L.C. |
132,728 |
800,000 |
1.45% |
|
|
| 11 |
DEUTSCHE BANK AG\ |
126,932 |
764,000 |
1.38% |
|
|
| 12 |
PUTNAM INVESTMENTS LLC |
123,527 |
745,000 |
1.35% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
114,647 |
691,000 |
1.25% |
|
|
| 14 |
BVF INC/IL |
106,700 |
643,000 |
1.17% |
|
|
| 15 |
CQS Cayman LP |
100,850 |
608,000 |
1.10% |
|
|
| 16 |
BAKER BROS. ADVISORS LP |
100,000 |
603,000 |
1.09% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
98,029 |
591,000 |
1.07% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
75,529 |
455,000 |
0.82% |
|
|
| 19 |
TFS CAPITAL LLC |
69,527 |
419,000 |
0.76% |
|
|
| 20 |
NORTHERN TRUST CORP |
62,697 |
378,000 |
0.68% |
|
|
| 21 |
GABELLI FUNDS LLC |
55,000 |
332,000 |
0.60% |
|
|
| 22 |
A.R.T. Advisors, LLC |
48,378 |
291,000 |
0.53% |
|
|
| 23 |
BlackRock Fund Advisors |
46,761 |
282,000 |
0.51% |
|
|
| 24 |
BlackRock Group LTD |
38,834 |
234,000 |
0.42% |
|
|
| 25 |
JPMORGAN CHASE & CO |
37,686 |
227,000 |
0.41% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
35,328 |
213,000 |
0.39% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
26,408 |
159,000 |
0.29% |
|
|
| 28 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
23,100 |
139,000 |
0.25% |
|
|
| 29 |
CREDIT SUISSE AG/ |
21,907 |
132,000 |
0.24% |
|
|
| 30 |
MORGAN STANLEY |
16,917 |
102,000 |
0.18% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
16,164 |
97,000 |
0.18% |
|
|
| 32 |
Alyeska Investment Group, L.P. |
14,188 |
86,000 |
0.16% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,422 |
81,000 |
0.15% |
|
|
| 34 |
Squarepoint Ops LLC |
12,500 |
75,000 |
0.14% |
|
|
| 35 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
12,242 |
74,000 |
0.13% |
|
|
| 36 |
Paloma Partners Management Co |
10,650 |
64,000 |
0.12% |
|
|
| 37 |
PRELUDE CAPITAL MANAGEMENT, LLC |
10,300 |
62,000 |
0.11% |
|
|
| 38 |
Alpine Global Management, LLC |
4,746 |
29,000 |
0.05% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
3,838 |
23,000 |
0.04% |
|
|
| 40 |
BlackRock Investment Management, LLC |
2,981 |
18,000 |
0.03% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
1,702 |
10,000 |
0.02% |
|
|
| 42 |
BARCLAYS PLC |
1,601 |
10,000 |
0.02% |
|
|
| 43 |
UBS Group AG |
1,500 |
9,000 |
0.02% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
1,010 |
6,000 |
0.01% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
194 |
1,000 |
0.00% |
|
|
| 46 |
CITIGROUP INC |
39 |
0 |
0.00% |
|
|
| 47 |
ROYAL BANK OF CANADA |
30 |
0 |
0.00% |
|
|
