| 1 |
FMR LLC |
2,759,197 |
7,616,000 |
33.88% |
|
|
| 2 |
Versant Venture Management, LLC |
1,281,152 |
3,535,979 |
15.73% |
|
|
| 3 |
WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST |
1,125,616 |
3,107,000 |
13.82% |
|
|
| 4 |
AXA S.A. |
542,733 |
1,498,000 |
6.66% |
|
|
| 5 |
VANGUARD GROUP INC |
323,727 |
893,000 |
3.97% |
|
|
| 6 |
Murphy Michael R |
318,619 |
879,000 |
3.91% |
|
|
| 7 |
Point72 Asset Management, L.P. |
260,691 |
720,000 |
3.20% |
|
|
| 8 |
Opaleye Management Inc. |
255,000 |
704,000 |
3.13% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
137,950 |
381,000 |
1.69% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
129,455 |
357,000 |
1.59% |
|
|
| 11 |
PUTNAM INVESTMENTS LLC |
123,527 |
341,000 |
1.52% |
|
|
| 12 |
BAKER BROS. ADVISORS LP |
100,000 |
276,000 |
1.23% |
|
|
| 13 |
CQS Cayman LP |
90,850 |
251,000 |
1.12% |
|
|
| 14 |
Spark Investment Management LLC |
86,000 |
237,000 |
1.05% |
|
|
| 15 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
85,472 |
236,000 |
1.05% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
64,400 |
178,000 |
0.79% |
|
|
| 17 |
PERCEPTIVE ADVISORS LLC |
60,000 |
166,000 |
0.74% |
|
|
| 18 |
GABELLI FUNDS LLC |
55,000 |
152,000 |
0.68% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
46,187 |
127,000 |
0.56% |
|
|
| 20 |
MORGAN STANLEY |
45,730 |
126,000 |
0.56% |
|
|
| 21 |
BlackRock Fund Advisors |
42,759 |
118,000 |
0.52% |
|
|
| 22 |
BlackRock Group LTD |
38,834 |
107,000 |
0.48% |
|
|
| 23 |
BANK OF AMERICA CORP /DE/ |
32,700 |
90,000 |
0.40% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
26,498 |
73,000 |
0.32% |
|
|
| 25 |
EAGLE GLOBAL ADVISORS LLC |
24,937 |
69,000 |
0.31% |
|
|
| 26 |
Ballentine Partners, LLC |
19,823 |
55,000 |
0.24% |
|
|
| 27 |
NORTHERN TRUST CORP |
15,300 |
42,000 |
0.19% |
|
|
| 28 |
ICONIQ Capital, LLC |
14,296 |
39,000 |
0.17% |
|
|
| 29 |
MILLENNIUM MANAGEMENT LLC |
10,921 |
30,000 |
0.13% |
|
|
| 30 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
8,200 |
23,000 |
0.10% |
|
|
| 31 |
RUSSELL FRANK CO/ |
7,147 |
20,000 |
0.09% |
|
|
| 32 |
BlackRock Investment Management, LLC |
3,196 |
9,000 |
0.04% |
|
|
| 33 |
Nationwide Fund Advisors |
2,200 |
6,000 |
0.03% |
|
|
| 34 |
UBS Group AG |
1,500 |
4,000 |
0.02% |
|
|
| 35 |
GIERL AUGUSTINE INVESTMENT MANAGEMENT INC |
1,000 |
3,000 |
0.01% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
998 |
3,000 |
0.01% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
611 |
2,000 |
0.01% |
|
|
| 38 |
Tower Research Capital LLC (TRC) |
850 |
2,000 |
0.01% |
|
|
| 39 |
BlackRock Japan Co. Ltd |
799 |
2,000 |
0.01% |
|
|
| 40 |
PRELUDE CAPITAL MANAGEMENT, LLC |
400 |
1,000 |
0.00% |
|
|
| 41 |
ACADIAN ASSET MANAGEMENT LLC |
228 |
1,000 |
0.00% |
|
|
| 42 |
CITIGROUP INC |
210 |
1,000 |
0.00% |
|
|
| 43 |
SIMPLEX TRADING, LLC |
185 |
0 |
0.00% |
|
|
| 44 |
Creative Planning |
100 |
0 |
0.00% |
|
|
