| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,652,097 | 25,885,000 | 29.73% | ||
| 2 | Versant Venture Management, LLC | 1,281,152 | 12,504,044 | 14.36% | ||
| 3 | MAZAMA CAPITAL MANAGEMENT INC | 675,059 | 6,589,000 | 7.57% | ||
| 4 | Omega Fund Management, LLC | 481,694 | 4,701,000 | 5.40% | ||
| 5 | Redmile Group, LLC | 398,340 | 3,888,000 | 4.47% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 332,341 | 3,244,000 | 3.73% | ||
| 7 | AXA S.A. | 279,591 | 2,729,000 | 3.13% | ||
| 8 | VANGUARD GROUP INC | 238,020 | 2,323,000 | 2.67% | ||
| 9 | BLACKROCK ADVISORS LLC | 205,760 | 2,008,000 | 2.31% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 194,801 | 1,902,000 | 2.18% | ||
| 11 | BlackRock Fund Advisors | 192,347 | 1,877,000 | 2.16% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 163,670 | 1,597,000 | 1.83% | ||
| 13 | PRINCIPAL FINANCIAL GROUP INC | 156,100 | 1,524,000 | 1.75% | ||
| 14 | BlackRock Group LTD | 142,764 | 1,393,000 | 1.60% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 140,599 | 1,372,000 | 1.58% | ||
| 16 | BVF INC/IL | 136,600 | 1,333,000 | 1.53% | ||
| 17 | New Leaf Venture Partners, L.L.C. | 128,728 | 1,256,000 | 1.44% | ||
| 18 | STATE STREET CORP | 126,096 | 1,233,000 | 1.42% | ||
| 19 | PUTNAM INVESTMENTS LLC | 123,527 | 1,206,000 | 1.39% | ||
| 20 | BAKER BROS. ADVISORS LP | 100,000 | 976,000 | 1.12% | ||
| 21 | CQS Cayman LP | 73,850 | 721,000 | 0.83% | ||
| 22 | NORTHERN TRUST CORP | 70,541 | 688,000 | 0.79% | ||
| 23 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 69,400 | 677,000 | 0.78% | ||
| 24 | PERCEPTIVE ADVISORS LLC | 60,000 | 586,000 | 0.67% | ||
| 25 | GABELLI FUNDS LLC | 59,000 | 576,000 | 0.66% | ||
| 26 | BlackRock Finance, Inc. | 50,573 | 494,000 | 0.57% | ||
| 27 | Spark Investment Management LLC | 41,900 | 408,000 | 0.47% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 41,076 | 400,000 | 0.46% | ||
| 29 | TFS CAPITAL LLC | 29,803 | 291,000 | 0.33% | ||
| 30 | JPMORGAN CHASE & CO | 29,205 | 286,000 | 0.33% | ||
| 31 | MORGAN STANLEY | 26,501 | 259,000 | 0.30% | ||
| 32 | Bank of New York Mellon Corp | 25,424 | 248,000 | 0.28% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 23,700 | 231,000 | 0.27% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 22,168 | 216,000 | 0.25% | ||
| 35 | BlackRock Investment Management, LLC | 20,546 | 201,000 | 0.23% | ||
| 36 | Numeric Investors LLC | 18,300 | 179,000 | 0.21% | ||
| 37 | GOLDMAN SACHS GROUP INC | 14,547 | 142,000 | 0.16% | ||
| 38 | Alyeska Investment Group, L.P. | 13,961 | 136,000 | 0.16% | ||
| 39 | TD ASSET MANAGEMENT INC | 13,600 | 133,000 | 0.15% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,726 | 124,000 | 0.14% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,100 | 99,000 | 0.11% | ||
| 42 | TEACHERS ADVISORS, LLC | 9,454 | 92,000 | 0.11% | ||
| 43 | PANAGORA ASSET MANAGEMENT INC | 7,408 | 72,000 | 0.08% | ||
| 44 | Nationwide Fund Advisors | 5,234 | 51,000 | 0.06% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 4,339 | 42,349 | 0.05% | ||
| 46 | CITADEL ADVISORS LLC | 3,664 | 36,000 | 0.04% | ||
| 47 | ACADIAN ASSET MANAGEMENT LLC | 3,194 | 31,000 | 0.04% | ||
| 48 | DEUTSCHE BANK AG\ | 3,050 | 29,000 | 0.03% | ||
| 49 | BlackRock Japan Co. Ltd | 1,940 | 19,000 | 0.02% | ||
| 50 | Tower Research Capital LLC (TRC) | 1,543 | 15,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
