| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,652,097 | 23,763,000 | 31.35% | ||
| 2 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 1,575,478 | 14,116,000 | 18.62% | ||
| 3 | Redmile Group, LLC | 770,422 | 6,903,000 | 9.11% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 434,801 | 3,896,000 | 5.14% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 394,600 | 3,536,000 | 4.67% | ||
| 6 | AXA S.A. | 245,703 | 2,201,000 | 2.90% | ||
| 7 | BLACKROCK ADVISORS LLC | 235,122 | 2,106,000 | 2.78% | ||
| 8 | MAZAMA CAPITAL MANAGEMENT INC | 218,834 | 1,961,000 | 2.59% | ||
| 9 | VANGUARD GROUP INC | 217,012 | 1,945,000 | 2.57% | ||
| 10 | BlackRock Fund Advisors | 163,115 | 1,462,000 | 1.93% | ||
| 11 | PRINCIPAL FINANCIAL GROUP INC | 150,000 | 1,344,000 | 1.77% | ||
| 12 | BVF INC/IL | 136,600 | 1,224,000 | 1.61% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 132,678 | 1,189,000 | 1.57% | ||
| 14 | PUTNAM INVESTMENTS LLC | 123,527 | 1,107,000 | 1.46% | ||
| 15 | STATE STREET CORP | 118,606 | 1,064,000 | 1.40% | ||
| 16 | BlackRock Group LTD | 114,441 | 1,025,000 | 1.35% | ||
| 17 | BAKER BROS. ADVISORS LP | 100,000 | 896,000 | 1.18% | ||
| 18 | NORTHERN TRUST CORP | 72,259 | 647,000 | 0.85% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 70,550 | 632,000 | 0.83% | ||
| 20 | GABELLI FUNDS LLC | 65,000 | 582,000 | 0.77% | ||
| 21 | Hutchin Hill Capital, LP | 61,695 | 553,000 | 0.73% | ||
| 22 | PERCEPTIVE ADVISORS LLC | 60,000 | 538,000 | 0.71% | ||
| 23 | BlackRock Finance, Inc. | 50,573 | 453,000 | 0.60% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 32,528 | 291,000 | 0.38% | ||
| 25 | JPMORGAN CHASE & CO | 30,400 | 272,000 | 0.36% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 26,391 | 236,000 | 0.31% | ||
| 27 | Bank of New York Mellon Corp | 24,222 | 217,000 | 0.29% | ||
| 28 | TFS CAPITAL LLC | 21,272 | 191,000 | 0.25% | ||
| 29 | BlackRock Investment Management, LLC | 20,546 | 184,000 | 0.24% | ||
| 30 | TD ASSET MANAGEMENT INC | 16,500 | 148,000 | 0.20% | ||
| 31 | A.R.T. Advisors, LLC | 16,331 | 146,000 | 0.19% | ||
| 32 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 15,000 | 134,000 | 0.18% | ||
| 33 | Alyeska Investment Group, L.P. | 13,414 | 120,000 | 0.16% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,672 | 114,000 | 0.15% | ||
| 35 | BANQUE PICTET & CIE SA | 10,625 | 95,000 | 0.13% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,100 | 91,000 | 0.12% | ||
| 37 | Weiss Multi-Strategy Advisers LLC | 10,000 | 90,000 | 0.12% | ||
| 38 | TEACHERS ADVISORS, LLC | 9,454 | 85,000 | 0.11% | ||
| 39 | Nationwide Fund Advisors | 5,234 | 47,000 | 0.06% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 4,512 | 40,428 | 0.05% | ||
| 41 | ROYAL BANK OF CANADA | 4,500 | 40,000 | 0.05% | ||
| 42 | MORGAN STANLEY | 4,305 | 39,000 | 0.05% | ||
| 43 | DEUTSCHE BANK AG\ | 2,461 | 21,000 | 0.03% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,914 | 17,000 | 0.02% | ||
| 45 | UBS AG | 1,036 | 9,000 | 0.01% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 900 | 8,000 | 0.01% | ||
| 47 | PNC FINANCIAL SERVICES GROUP, INC. | 620 | 6,000 | 0.01% | ||
| 48 | WELLS FARGO & COMPANY/MN | 318 | 3,000 | 0.00% | ||
| 49 | CITIGROUP INC | 240 | 2,000 | 0.00% | ||
| 50 | BNP PARIBAS FINANCIAL MARKETS | 114 | 1,021 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
