| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 5,215,125 | 67,901,000 | 18.84% | ||
| 2 | BAKER BROS. ADVISORS LP | 4,582,382 | 59,663,000 | 16.56% | ||
| 3 | FMR LLC | 2,906,489 | 37,842,000 | 10.50% | ||
| 4 | FORESITE CAPITAL MANAGEMENT III, LLC | 2,607,984 | 33,956,000 | 9.42% | ||
| 5 | Polar Capital LLP | 1,750,000 | 22,785,000 | 6.32% | ||
| 6 | Versant Venture Management, LLC | 1,281,152 | 16,680,599 | 4.63% | ||
| 7 | VANGUARD GROUP INC | 959,295 | 12,490,000 | 3.47% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 811,632 | 10,567,000 | 2.93% | ||
| 9 | EverPoint Asset Management, LLC | 675,000 | 8,789,000 | 2.44% | ||
| 10 | Point72 Asset Management, L.P. | 657,900 | 8,566,000 | 2.38% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 514,342 | 6,697,000 | 1.86% | ||
| 12 | Informed Momentum Co LLC | 432,715 | 5,634,000 | 1.56% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 430,796 | 5,609,000 | 1.56% | ||
| 14 | SCHONFELD STRATEGIC ADVISORS LLC | 415,189 | 5,406,000 | 1.50% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 377,200 | 4,911,000 | 1.36% | ||
| 16 | FARALLON CAPITAL MANAGEMENT LLC | 350,000 | 4,557,000 | 1.26% | ||
| 17 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 339,584 | 4,421,000 | 1.23% | ||
| 18 | AXA S.A. | 267,844 | 3,487,000 | 0.97% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 193,300 | 2,517,000 | 0.70% | Call | |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 165,473 | 2,155,000 | 0.60% | ||
| 21 | Nicholas Investment Partners, LP | 159,191 | 2,072,000 | 0.57% | ||
| 22 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 156,185 | 2,034,000 | 0.56% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 139,955 | 1,822,000 | 0.51% | ||
| 24 | DEUTSCHE BANK AG\ | 139,810 | 1,820,000 | 0.51% | ||
| 25 | AWM Investment Company, Inc. | 121,100 | 1,577,000 | 0.44% | ||
| 26 | Bank of New York Mellon Corp | 110,633 | 1,440,000 | 0.40% | ||
| 27 | RUSSELL INVESTMENTS GROUP, LTD. | 106,430 | 1,415,000 | 0.39% | ||
| 28 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 1,302,000 | 0.36% | ||
| 29 | Spark Investment Management LLC | 99,700 | 1,298,000 | 0.36% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 95,700 | 1,246,000 | 0.35% | Put | |
| 31 | Candriam S.C.A. | 90,000 | 1,172,000 | 0.33% | ||
| 32 | AMERIPRISE FINANCIAL INC | 84,334 | 1,098,000 | 0.30% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,500 | 1,074,000 | 0.30% | Call | |
| 34 | Opaleye Management Inc. | 80,000 | 1,041,000 | 0.29% | ||
| 35 | GRATICULE ASIA MACRO ADVISORS LLC | 75,000 | 977,000 | 0.27% | ||
| 36 | BlackRock Fund Advisors | 72,653 | 946,000 | 0.26% | ||
| 37 | PAULSON & CO. INC. | 72,500 | 944,000 | 0.26% | ||
| 38 | SIMPLEX TRADING, LLC | 63,754 | 830,000 | 0.23% | ||
| 39 | GABELLI FUNDS LLC | 61,800 | 805,000 | 0.22% | ||
| 40 | Artal Group S.A. | 60,000 | 781,000 | 0.22% | ||
| 41 | Columbia Pacific Advisors, LLC | 55,000 | 716,000 | 0.20% | ||
| 42 | CITADEL ADVISORS LLC | 53,385 | 695,000 | 0.19% | ||
| 43 | Alyeska Investment Group, L.P. | 50,000 | 651,000 | 0.18% | ||
| 44 | Iguana Healthcare Management, LLC | 50,000 | 651,000 | 0.18% | ||
| 45 | TUDOR INVESTMENT CORP ET AL | 50,000 | 651,000 | 0.18% | ||
| 46 | ESSEX INVESTMENT MANAGEMENT CO LLC | 37,572 | 489,000 | 0.14% | ||
| 47 | Hatteras Investment Partners, LP | 37,472 | 488,000 | 0.14% | ||
| 48 | NORTHERN TRUST CORP | 33,866 | 441,000 | 0.12% | ||
| 49 | ACADIAN ASSET MANAGEMENT LLC | 32,271 | 421,000 | 0.12% | ||
| 50 | ELLINGTON MANAGEMENT GROUP LLC | 30,000 | 391,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
