| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,652,097 | 41,002,000 | 33.48% | ||
| 2 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 1,575,478 | 24,357,000 | 19.89% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 861,000 | 13,312,000 | 10.87% | ||
| 4 | Redmile Group, LLC | 653,700 | 10,106,000 | 8.25% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 387,000 | 5,983,000 | 4.89% | ||
| 6 | BLACKROCK ADVISORS LLC | 342,100 | 5,288,000 | 4.32% | ||
| 7 | AXA S.A. | 167,046 | 2,583,000 | 2.11% | ||
| 8 | PRINCIPAL FINANCIAL GROUP INC | 150,000 | 2,319,000 | 1.89% | ||
| 9 | BlackRock Group LTD | 139,900 | 2,163,000 | 1.77% | ||
| 10 | BVF INC/IL | 125,000 | 1,933,000 | 1.58% | ||
| 11 | PUTNAM INVESTMENTS LLC | 123,527 | 1,910,000 | 1.56% | ||
| 12 | BAKER BROS. ADVISORS LP | 100,000 | 1,546,000 | 1.26% | ||
| 13 | VANGUARD GROUP INC | 100,000 | 1,546,000 | 1.26% | ||
| 14 | JPMORGAN CHASE & CO | 74,725 | 1,155,000 | 0.94% | ||
| 15 | BlackRock Finance, Inc. | 70,900 | 1,096,000 | 0.89% | ||
| 16 | Hutchin Hill Capital, LP | 65,395 | 1,011,000 | 0.83% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 60,000 | 928,000 | 0.76% | ||
| 18 | Iguana Healthcare Management, LLC | 55,000 | 851,000 | 0.69% | ||
| 19 | Alyeska Investment Group, L.P. | 43,817 | 677,000 | 0.55% | ||
| 20 | BOKF, NA | 30,000 | 464,000 | 0.38% | ||
| 21 | ARROWGRASS CAPITAL PARTNERS (US) LP | 27,693 | 428,000 | 0.35% | ||
| 22 | PEAK6 Group LLC | 21,000 | 325,000 | 0.27% | ||
| 23 | TUDOR INVESTMENT CORP ET AL | 20,000 | 309,000 | 0.25% | ||
| 24 | DEUTSCHE BANK AG\ | 18,025 | 278,000 | 0.23% | ||
| 25 | TD ASSET MANAGEMENT INC | 16,500 | 255,000 | 0.21% | ||
| 26 | Virtu KCG Holdings LLC | 14,196 | 219,000 | 0.18% | ||
| 27 | NORTHERN TRUST CORP | 10,303 | 159,000 | 0.13% | ||
| 28 | MAZAMA CAPITAL MANAGEMENT INC | 8,319 | 129,000 | 0.11% | ||
| 29 | UBS AG | 6,923 | 107,000 | 0.09% | ||
| 30 | WELLS FARGO & COMPANY/MN | 750 | 12,000 | 0.01% | ||
| 31 | Tower Research Capital LLC (TRC) | 395 | 6,000 | 0.00% | ||
| 32 | MORGAN STANLEY | 234 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
