| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,652,097 | 34,610,000 | 26.03% | ||
| 2 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 1,526,955 | 19,927,000 | 14.99% | ||
| 3 | Versant Venture Management, LLC | 1,281,152 | 12,504,044 | 9.40% | ||
| 4 | Redmile Group, LLC | 733,953 | 9,578,000 | 7.20% | ||
| 5 | Omega Fund Management, LLC | 656,899 | 8,573,000 | 6.45% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 429,577 | 5,607,000 | 4.22% | ||
| 7 | MAZAMA CAPITAL MANAGEMENT INC | 417,331 | 5,446,000 | 4.10% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 394,600 | 5,150,000 | 3.87% | ||
| 9 | AXA S.A. | 262,498 | 3,426,000 | 2.58% | ||
| 10 | VANGUARD GROUP INC | 234,911 | 3,066,000 | 2.31% | ||
| 11 | BLACKROCK ADVISORS LLC | 205,360 | 2,680,000 | 2.02% | ||
| 12 | BlackRock Fund Advisors | 189,309 | 2,470,000 | 1.86% | ||
| 13 | PRINCIPAL FINANCIAL GROUP INC | 154,700 | 2,019,000 | 1.52% | ||
| 14 | BVF INC/IL | 136,600 | 1,783,000 | 1.34% | ||
| 15 | STATE STREET CORP | 125,468 | 1,637,000 | 1.23% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 123,748 | 1,615,000 | 1.21% | ||
| 17 | PUTNAM INVESTMENTS LLC | 123,527 | 1,612,000 | 1.21% | ||
| 18 | BlackRock Group LTD | 114,441 | 1,493,000 | 1.12% | ||
| 19 | BAKER BROS. ADVISORS LP | 100,000 | 1,305,000 | 0.98% | ||
| 20 | NORTHERN TRUST CORP | 69,538 | 908,000 | 0.68% | ||
| 21 | CQS Cayman LP | 66,150 | 863,000 | 0.65% | ||
| 22 | GABELLI FUNDS LLC | 61,500 | 803,000 | 0.60% | ||
| 23 | PERCEPTIVE ADVISORS LLC | 60,000 | 783,000 | 0.59% | ||
| 24 | BlackRock Finance, Inc. | 50,573 | 660,000 | 0.50% | ||
| 25 | DEUTSCHE BANK AG\ | 42,523 | 554,000 | 0.42% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 34,636 | 451,000 | 0.34% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 28,152 | 367,000 | 0.28% | ||
| 28 | JPMORGAN CHASE & CO | 27,150 | 354,000 | 0.27% | ||
| 29 | Bank of New York Mellon Corp | 23,317 | 305,000 | 0.23% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 22,168 | 289,000 | 0.22% | ||
| 31 | BlackRock Investment Management, LLC | 20,546 | 268,000 | 0.20% | ||
| 32 | TFS CAPITAL LLC | 17,250 | 225,000 | 0.17% | ||
| 33 | TD ASSET MANAGEMENT INC | 16,500 | 215,000 | 0.16% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 15,000 | 196,000 | 0.15% | ||
| 35 | Alyeska Investment Group, L.P. | 12,935 | 169,000 | 0.13% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,726 | 166,000 | 0.12% | ||
| 37 | Polar Capital LLP | 11,700 | 153,000 | 0.12% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,100 | 132,000 | 0.10% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 10,000 | 131,000 | 0.10% | ||
| 40 | TEACHERS ADVISORS, LLC | 9,454 | 123,000 | 0.09% | ||
| 41 | ROYAL BANK OF CANADA | 6,000 | 78,000 | 0.06% | ||
| 42 | Nationwide Fund Advisors | 5,234 | 68,000 | 0.05% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 4,339 | 56,624 | 0.04% | ||
| 44 | MORGAN STANLEY | 2,805 | 37,000 | 0.03% | ||
| 45 | BARCLAYS PLC | 2,792 | 36,000 | 0.03% | ||
| 46 | UBS Group AG | 1,557 | 21,000 | 0.02% | ||
| 47 | Tower Research Capital LLC (TRC) | 1,505 | 20,000 | 0.02% | ||
| 48 | CITIGROUP INC | 1,413 | 18,000 | 0.01% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 900 | 12,000 | 0.01% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 600 | 8,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
