| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 4,763,602 | 49,303,000 | 10.48% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 4,016,990 | 41,576,000 | 8.84% | ||
| 3 | VICTORY CAPITAL MANAGEMENT INC | 3,638,632 | 37,660,000 | 8.00% | ||
| 4 | BlackRock Finance, Inc. | 3,047,562 | 31,541,000 | 6.70% | ||
| 5 | Broadfin Capital, LLC | 2,941,247 | 30,442,000 | 6.47% | ||
| 6 | FRAZIER MANAGEMENT LLC | 2,173,593 | 22,497,000 | 4.78% | ||
| 7 | PFM Health Sciences, LP | 1,820,496 | 18,842,000 | 4.00% | ||
| 8 | VANGUARD GROUP INC | 1,776,484 | 18,387,000 | 3.91% | ||
| 9 | GREAT POINT PARTNERS LLC | 1,749,323 | 18,105,000 | 3.85% | ||
| 10 | EMERALD ADVISERS, LLC | 1,633,345 | 16,905,000 | 3.59% | ||
| 11 | Cormorant Asset Management, LP | 1,500,000 | 15,525,000 | 3.30% | SH | |
| 12 | EMERALD MUTUAL FUND ADVISERS TRUST | 1,161,202 | 12,018,000 | 2.55% | ||
| 13 | FARALLON CAPITAL MANAGEMENT LLC | 1,153,500 | 11,939,000 | 2.54% | ||
| 14 | ARMISTICE CAPITAL, LLC | 1,000,000 | 10,350,000 | 2.20% | ||
| 15 | Artal Group S.A. | 900,000 | 9,315,000 | 1.98% | ||
| 16 | BAKER BROS. ADVISORS LP | 896,000 | 9,274,000 | 1.97% | ||
| 17 | JPMORGAN CHASE & CO | 882,733 | 9,137,000 | 1.94% | ||
| 18 | STATE STREET CORP | 766,404 | 7,931,000 | 1.69% | ||
| 19 | BVF INC/IL | 700,000 | 7,245,000 | 1.54% | ||
| 20 | PointState Capital LP | 580,100 | 6,004,000 | 1.28% | ||
| 21 | Lombard Odier Asset Management (USA) Corp | 575,000 | 5,951,000 | 1.26% | ||
| 22 | Pier Capital, LLC | 562,582 | 5,823,000 | 1.24% | ||
| 23 | NORTHERN TRUST CORP | 554,839 | 5,743,000 | 1.22% | ||
| 24 | FMR LLC | 477,131 | 4,938,000 | 1.05% | ||
| 25 | SPHERA FUNDS MANAGEMENT LTD. | 400,000 | 4,140,000 | 0.88% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 380,289 | 3,935,000 | 0.84% | ||
| 27 | MORGAN STANLEY | 360,047 | 3,726,000 | 0.79% | ||
| 28 | EVENTIDE ASSET MANAGEMENT, LLC | 344,000 | 3,560,000 | 0.76% | ||
| 29 | AXA S.A. | 314,187 | 3,252,000 | 0.69% | ||
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 299,240 | 3,097,000 | 0.66% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 287,394 | 2,975,000 | 0.63% | ||
| 32 | Point72 Asset Management, L.P. | 277,900 | 2,876,000 | 0.61% | ||
| 33 | NEXTHERA CAPITAL LP | 250,000 | 2,588,000 | 0.55% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 222,146 | 2,299,000 | 0.49% | ||
| 35 | Opus Point Partners Management, LLC | 170,500 | 1,765,000 | 0.38% | ||
| 36 | Bank of New York Mellon Corp | 165,981 | 1,718,000 | 0.37% | ||
| 37 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 147,295 | 1,524,000 | 0.32% | ||
| 38 | GREENWOODS ASSET MANAGEMENT LTD | 136,000 | 1,408,000 | 0.30% | ||
| 39 | Endurant Capital Management LP | 132,400 | 1,370,000 | 0.29% | ||
| 40 | PANAGORA ASSET MANAGEMENT INC | 123,688 | 1,280,000 | 0.27% | ||
| 41 | PAULSON & CO. INC. | 123,000 | 1,273,000 | 0.27% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,745 | 1,219,000 | 0.26% | ||
| 43 | Polar Capital LLP | 100,000 | 1,035,000 | 0.22% | ||
| 44 | Crestline Management, LP | 92,561 | 958,000 | 0.20% | ||
| 45 | TEACHERS ADVISORS, LLC | 88,972 | 921,000 | 0.20% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,511 | 916,000 | 0.19% | ||
| 47 | Telemetry Investments, L.L.C. | 83,500 | 864,000 | 0.18% | ||
| 48 | CITADEL ADVISORS LLC | 76,585 | 793,000 | 0.17% | ||
| 49 | ALTRINSIC GLOBAL ADVISORS LLC | 70,000 | 725,000 | 0.15% | ||
| 50 | HANDELSBANKEN FONDER AB | 70,000 | 724,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
