| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 1,927,171 | 30,912,000 | 13.76% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 1,582,600 | 25,385,000 | 11.30% | ||
| 3 | FMR LLC | 1,440,419 | 23,104,000 | 10.28% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,400,000 | 22,456,000 | 9.99% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,399,423 | 22,447,000 | 9.99% | ||
| 6 | ORBIMED ADVISORS LLC | 1,046,000 | 16,778,000 | 7.47% | ||
| 7 | QVT Financial LP | 651,444 | 9,843,000 | 4.38% | ||
| 8 | BAKER BROS. ADVISORS LP | 591,371 | 9,486,000 | 4.22% | ||
| 9 | Foresite Capital Management I, LLC | 582,881 | 9,349,000 | 4.16% | ||
| 10 | Broadfin Capital, LLC | 520,881 | 8,355,000 | 3.72% | ||
| 11 | VANGUARD GROUP INC | 417,953 | 6,704,000 | 2.98% | ||
| 12 | BlackRock Fund Advisors | 405,677 | 6,507,000 | 2.90% | ||
| 13 | STATE STREET CORP | 215,580 | 3,457,000 | 1.54% | ||
| 14 | NORTHERN TRUST CORP | 153,954 | 2,470,000 | 1.10% | ||
| 15 | FRANKLIN RESOURCES INC | 151,301 | 2,427,000 | 1.08% | ||
| 16 | JPMORGAN CHASE & CO | 137,275 | 2,202,000 | 0.98% | ||
| 17 | SPHINX TRADING, LP | 131,431 | 2,108,000 | 0.94% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 125,250 | 2,009,000 | 0.89% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 104,511 | 1,676,000 | 0.75% | ||
| 20 | Candriam S.C.A. | 95,000 | 1,524,000 | 0.68% | ||
| 21 | ALLIANCEBERNSTEIN L.P. | 86,050 | 1,380,000 | 0.61% | ||
| 22 | RUSSELL FRANK CO/ | 63,126 | 1,043,000 | 0.46% | ||
| 23 | Bank of New York Mellon Corp | 64,251 | 1,031,000 | 0.46% | ||
| 24 | Informed Momentum Co LLC | 60,040 | 963,000 | 0.43% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,812 | 895,000 | 0.40% | ||
| 26 | Rhenman & Partners Asset Management AB | 50,000 | 802,000 | 0.36% | ||
| 27 | MACQUARIE GROUP LTD | 50,000 | 802,000 | 0.36% | ||
| 28 | Opus Point Partners Management, LLC | 44,698 | 717,000 | 0.32% | ||
| 29 | BlackRock Investment Management, LLC | 42,741 | 686,000 | 0.31% | ||
| 30 | GOLDMAN SACHS GROUP INC | 37,048 | 594,000 | 0.26% | ||
| 31 | MORGAN STANLEY | 35,952 | 576,000 | 0.26% | ||
| 32 | D. E. Shaw & Co., Inc. | 33,822 | 543,000 | 0.24% | ||
| 33 | Alyeska Investment Group, L.P. | 33,413 | 536,000 | 0.24% | ||
| 34 | OPPENHEIMER & CO INC | 31,600 | 507,000 | 0.23% | ||
| 35 | TFS CAPITAL LLC | 28,012 | 449,000 | 0.20% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,070 | 434,000 | 0.19% | ||
| 37 | ACUTA CAPITAL PARTNERS, LLC | 22,011 | 353,000 | 0.16% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,900 | 352,000 | 0.16% | ||
| 39 | TEACHERS ADVISORS, LLC | 21,875 | 351,000 | 0.16% | ||
| 40 | BLACKROCK ADVISORS LLC | 19,484 | 313,000 | 0.14% | ||
| 41 | Capital Impact Advisors, LLC | 15,461 | 248,000 | 0.11% | ||
| 42 | A.R.T. Advisors, LLC | 14,477 | 232,000 | 0.10% | ||
| 43 | METROPOLITAN LIFE INSURANCE CO/NY | 12,563 | 202,000 | 0.09% | ||
| 44 | First Allied Advisory Services, Inc. | 12,000 | 192,000 | 0.09% | ||
| 45 | Nationwide Fund Advisors | 11,245 | 180,000 | 0.08% | ||
| 46 | RHUMBLINE ADVISERS | 10,845 | 174,000 | 0.08% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,816 | 173,000 | 0.08% | ||
| 48 | TWO SIGMA INVESTMENTS, LP | 10,703 | 172,000 | 0.08% | ||
| 49 | DEUTSCHE BANK AG\ | 9,797 | 156,000 | 0.07% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 9,213 | 147,777 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
