| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,690,258 | 141,232,000 | 18.16% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 6,121,243 | 129,219,000 | 16.62% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,733,498 | 78,814,000 | 10.14% | ||
| 4 | BlackRock Finance, Inc. | 3,078,061 | 64,978,000 | 8.36% | ||
| 5 | VANGUARD GROUP INC | 1,701,209 | 35,913,000 | 4.62% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,293,095 | 27,297,000 | 3.51% | ||
| 7 | Redmile Group, LLC | 1,187,494 | 25,068,000 | 3.22% | ||
| 8 | STATE STREET CORP | 1,103,455 | 23,295,000 | 3.00% | ||
| 9 | BAKER BROS. ADVISORS LP | 872,072 | 18,409,000 | 2.37% | ||
| 10 | ORBIMED ADVISORS LLC | 747,244 | 15,774,000 | 2.03% | ||
| 11 | NORGES BANK | 727,553 | 15,359,000 | 1.98% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 562,236 | 11,869,000 | 1.53% | ||
| 13 | FRANKLIN RESOURCES INC | 519,732 | 10,972,000 | 1.41% | ||
| 14 | NORTHERN TRUST CORP | 498,616 | 10,527,000 | 1.35% | ||
| 15 | Invesco Ltd. | 481,736 | 10,170,000 | 1.31% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 377,558 | 7,970,000 | 1.02% | ||
| 17 | LORD, ABBETT & CO. LLC | 353,498 | 7,462,000 | 0.96% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 344,000 | 7,262,000 | 0.93% | ||
| 19 | TEACHERS ADVISORS, LLC | 330,042 | 6,967,000 | 0.90% | ||
| 20 | ArrowMark Colorado Holdings LLC | 321,713 | 6,791,000 | 0.87% | ||
| 21 | Matarin Capital Management, LLC | 304,799 | 6,434,307 | 0.83% | ||
| 22 | QVT Financial LP | 301,325 | 6,361,000 | 0.82% | ||
| 23 | JPMORGAN CHASE & CO | 289,500 | 6,112,000 | 0.79% | ||
| 24 | DIMENSIONAL FUND ADVISORS LP | 264,259 | 5,579,000 | 0.72% | ||
| 25 | Rhenman & Partners Asset Management AB | 259,556 | 5,479,000 | 0.70% | ||
| 26 | WELLS FARGO & COMPANY/MN | 249,212 | 5,260,000 | 0.68% | ||
| 27 | Cannell & Co. | 238,500 | 5,035,000 | 0.65% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 215,111 | 4,541,000 | 0.58% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 211,155 | 4,457,000 | 0.57% | ||
| 30 | Bank of New York Mellon Corp | 201,075 | 4,245,000 | 0.55% | ||
| 31 | Gotham Asset Management, LLC | 190,897 | 4,030,000 | 0.52% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 161,360 | 3,406,000 | 0.44% | ||
| 33 | MAVERICK CAPITAL LTD | 157,928 | 3,334,000 | 0.43% | ||
| 34 | GOLDMAN SACHS GROUP INC | 142,977 | 3,018,000 | 0.39% | ||
| 35 | AQR CAPITAL MANAGEMENT LLC | 142,289 | 3,004,000 | 0.39% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 104,943 | 2,215,000 | 0.28% | ||
| 37 | MARSHALL WACE NORTH AMERICA, L.P. | 85,564 | 1,797,000 | 0.23% | ||
| 38 | PNC FINANCIAL SERVICES GROUP, INC. | 82,956 | 1,752,000 | 0.23% | ||
| 39 | TD ASSET MANAGEMENT INC | 81,769 | 1,726,000 | 0.22% | ||
| 40 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 75,000 | 1,583,000 | 0.20% | ||
| 41 | Cormorant Asset Management, LP | 75,000 | 1,583,000 | 0.20% | SH | |
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 74,223 | 1,567,000 | 0.20% | ||
| 43 | EMORY UNIVERSITY | 70,640 | 1,491,000 | 0.19% | ||
| 44 | VIRGINIA RETIREMENT SYSTEMS ET Al | 69,300 | 1,463,000 | 0.19% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,434 | 1,424,000 | 0.18% | ||
| 46 | RUSSELL INVESTMENTS GROUP, LTD. | 64,661 | 1,365,000 | 0.18% | ||
| 47 | Swiss National Bank | 63,100 | 1,332,000 | 0.17% | ||
| 48 | Nationwide Fund Advisors | 59,504 | 1,256,000 | 0.16% | ||
| 49 | Candriam S.C.A. | 57,000 | 1,203,000 | 0.15% | ||
| 50 | MACQUARIE GROUP LTD | 55,000 | 1,161,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
