| # | % | |||||
|---|---|---|---|---|---|---|
| 101 | Invesco Ltd. | 481,736 | 10,170,000 | 1.31% | ||
| 102 | NORTHERN TRUST CORP | 498,616 | 10,527,000 | 1.35% | ||
| 103 | FRANKLIN RESOURCES INC | 519,732 | 10,972,000 | 1.41% | ||
| 104 | DEERFIELD MANAGEMENT COMPANY, L.P. | 562,236 | 11,869,000 | 1.53% | ||
| 105 | NORGES BANK | 727,553 | 15,359,000 | 1.98% | ||
| 106 | ORBIMED ADVISORS LLC | 747,244 | 15,774,000 | 2.03% | ||
| 107 | BAKER BROS. ADVISORS LP | 872,072 | 18,409,000 | 2.37% | ||
| 108 | STATE STREET CORP | 1,103,455 | 23,295,000 | 3.00% | ||
| 109 | Redmile Group, LLC | 1,187,494 | 25,068,000 | 3.22% | ||
| 110 | PERCEPTIVE ADVISORS LLC | 1,293,095 | 27,297,000 | 3.51% | ||
| 111 | VANGUARD GROUP INC | 1,701,209 | 35,913,000 | 4.62% | ||
| 112 | BlackRock Finance, Inc. | 3,078,061 | 64,978,000 | 8.36% | ||
| 113 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,733,498 | 78,814,000 | 10.14% | ||
| 114 | PRIMECAP MANAGEMENT CO/CA/ | 6,121,243 | 129,219,000 | 16.62% | ||
| 115 | FMR LLC | 6,690,258 | 141,232,000 | 18.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
