| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,383,412 | 79,690,000 | 39.71% | ||
| 2 | BLACKROCK ADVISORS LLC | 1,061,147 | 19,291,000 | 9.61% | ||
| 3 | Redmile Group, LLC | 1,001,060 | 18,199,000 | 9.07% | ||
| 4 | FRANKLIN RESOURCES INC | 840,300 | 15,277,000 | 7.61% | ||
| 5 | Visium Asset Management, LP | 700,479 | 12,735,000 | 6.35% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 7,272,000 | 3.62% | ||
| 7 | WALL STREET ASSOCIATES | 394,357 | 7,169,000 | 3.57% | ||
| 8 | BlackRock Group LTD | 340,933 | 6,198,000 | 3.09% | ||
| 9 | VANGUARD GROUP INC | 337,640 | 6,138,000 | 3.06% | ||
| 10 | Broadfin Capital, LLC | 224,234 | 4,077,000 | 2.03% | ||
| 11 | Alyeska Investment Group, L.P. | 194,563 | 3,537,000 | 1.76% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 171,437 | 3,117,000 | 1.55% | ||
| 13 | Sarissa Capital Management LP | 126,695 | 2,303,000 | 1.15% | ||
| 14 | MORGAN STANLEY | 122,688 | 2,230,000 | 1.11% | ||
| 15 | BlackRock Finance, Inc. | 104,800 | 1,905,000 | 0.95% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 1,818,000 | 0.91% | ||
| 17 | Rhenman & Partners Asset Management AB | 98,269 | 1,787,000 | 0.89% | ||
| 18 | ASCEND CAPITAL, LLC | 81,231 | 1,477,000 | 0.74% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 55,775 | 1,013,000 | 0.50% | ||
| 20 | DEUTSCHE BANK AG\ | 50,002 | 908,000 | 0.45% | ||
| 21 | State of New Jersey Common Pension Fund A | 45,000 | 818,000 | 0.41% | ||
| 22 | CREDIT SUISSE AG/ | 36,300 | 660,000 | 0.33% | ||
| 23 | HIGHLAND CAPITAL MANAGEMENT LP | 26,809 | 487,000 | 0.24% | ||
| 24 | NORTHERN TRUST CORP | 20,608 | 375,000 | 0.19% | ||
| 25 | Geduld E E | 20,030 | 364,000 | 0.18% | ||
| 26 | TUDOR INVESTMENT CORP ET AL | 20,000 | 364,000 | 0.18% | ||
| 27 | SAC Capital Advisors LP | 19,139 | 348,000 | 0.17% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,996 | 346,000 | 0.17% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 15,781 | 287,000 | 0.14% | ||
| 30 | STATE STREET CORP | 15,300 | 278,000 | 0.14% | ||
| 31 | BlackRock Institutional Trust Company, N.A. | 6,094 | 111,000 | 0.06% | ||
| 32 | Stifel Trust Company, N.A. | 2,500 | 46,000 | 0.02% | ||
| 33 | UBS AG | 1,842 | 33,000 | 0.02% | ||
| 34 | Tower Research Capital LLC (TRC) | 593 | 11,000 | 0.01% | ||
| 35 | BARCLAYS PLC | 100 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
