| 1 |
FMR LLC |
4,384,161 |
73,917,000 |
36.27% |
|
|
| 2 |
BLACKROCK ADVISORS LLC |
1,066,534 |
17,982,000 |
8.82% |
|
|
| 3 |
Redmile Group, LLC |
979,446 |
16,513,000 |
8.10% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
828,100 |
13,962,000 |
6.85% |
|
|
| 5 |
Visium Asset Management, LP |
700,479 |
11,810,000 |
5.80% |
|
|
| 6 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
450,000 |
7,587,000 |
3.72% |
|
|
| 7 |
BlackRock Fund Advisors |
421,993 |
7,115,000 |
3.49% |
|
|
| 8 |
VANGUARD GROUP INC |
394,932 |
6,658,000 |
3.27% |
|
|
| 9 |
WALL STREET ASSOCIATES |
393,257 |
6,630,000 |
3.25% |
|
|
| 10 |
BlackRock Group LTD |
340,933 |
5,748,000 |
2.82% |
|
|
| 11 |
MORGAN STANLEY |
241,561 |
4,074,000 |
2.00% |
|
|
| 12 |
Sarissa Capital Management LP |
215,202 |
3,628,000 |
1.78% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
199,648 |
3,366,000 |
1.65% |
|
|
| 14 |
STATE STREET CORP |
172,252 |
2,903,000 |
1.42% |
|
|
| 15 |
Alyeska Investment Group, L.P. |
125,493 |
2,116,000 |
1.04% |
|
|
| 16 |
BlackRock Investment Management, LLC |
108,908 |
1,836,000 |
0.90% |
|
|
| 17 |
BlackRock Finance, Inc. |
105,214 |
1,774,000 |
0.87% |
|
|
| 18 |
Rhenman & Partners Asset Management AB |
98,269 |
1,657,000 |
0.81% |
|
|
| 19 |
SPHERA FUNDS MANAGEMENT LTD. |
94,300 |
1,590,000 |
0.78% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
76,206 |
1,284,000 |
0.63% |
|
|
| 21 |
Bank of New York Mellon Corp |
73,500 |
1,239,000 |
0.61% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,725 |
1,091,000 |
0.54% |
|
|
| 23 |
Weiss Multi-Strategy Advisers LLC |
57,945 |
977,000 |
0.48% |
|
|
| 24 |
State of New Jersey Common Pension Fund D |
45,000 |
759,000 |
0.37% |
|
|
| 25 |
NORTHERN TRUST CORP |
44,099 |
743,000 |
0.36% |
|
|
| 26 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
43,712 |
737,000 |
0.36% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
32,667 |
550,000 |
0.27% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
31,200 |
526,000 |
0.26% |
|
|
| 29 |
GOLDMAN SACHS GROUP INC |
25,729 |
434,000 |
0.21% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
24,080 |
406,000 |
0.20% |
|
|
| 31 |
CREDIT SUISSE AG/ |
20,427 |
344,000 |
0.17% |
|
|
| 32 |
TFS CAPITAL LLC |
19,533 |
329,000 |
0.16% |
|
|
| 33 |
METROPOLITAN LIFE INSURANCE CO/NY |
18,580 |
313,000 |
0.15% |
|
|
| 34 |
SG Americas Securities, LLC |
17,816 |
300,000 |
0.15% |
|
|
| 35 |
First Eagle Investment Management, LLC |
17,500 |
295,000 |
0.14% |
|
|
| 36 |
MILLENNIUM MANAGEMENT LLC |
17,172 |
290,000 |
0.14% |
|
|
| 37 |
Swiss National Bank |
17,000 |
287,000 |
0.14% |
|
|
| 38 |
Nationwide Fund Advisors |
12,924 |
218,000 |
0.11% |
|
|
| 39 |
VOYA INVESTMENT MANAGEMENT LLC |
12,331 |
208,000 |
0.10% |
|
|
| 40 |
RHUMBLINE ADVISERS |
11,730 |
198,000 |
0.10% |
|
|
| 41 |
PANAGORA ASSET MANAGEMENT INC |
11,424 |
193,000 |
0.09% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
11,185 |
188,579 |
0.09% |
|
|
| 43 |
Stifel Trust Company, N.A. |
11,000 |
186,000 |
0.09% |
|
|
| 44 |
JANE STREET GROUP, LLC |
11,000 |
185,000 |
0.09% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,762 |
182,000 |
0.09% |
|
|
| 46 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,181 |
172,000 |
0.08% |
|
|
| 47 |
BANK OF AMERICA CORP /DE/ |
4,396 |
74,000 |
0.04% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
3,806 |
64,000 |
0.03% |
|
|
| 49 |
B. Riley Wealth Advisors, Inc. |
2,500 |
42,150 |
0.02% |
|
|
| 50 |
ALLIANCEBERNSTEIN L.P. |
2,400 |
40,000 |
0.02% |
|
|
