| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,453,382 | 347,127,000 | 22.47% | ||
| 2 | VANGUARD GROUP INC | 1,399,712 | 75,291,000 | 4.87% | ||
| 3 | TimesSquare Capital Management, LLC | 1,318,420 | 70,918,000 | 4.59% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,257,846 | 67,660,000 | 4.38% | ||
| 5 | Redmile Group, LLC | 1,223,717 | 65,824,000 | 4.26% | ||
| 6 | BLACKROCK ADVISORS LLC | 1,199,043 | 64,497,000 | 4.18% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,076,462 | 57,903,000 | 3.75% | ||
| 8 | Visium Asset Management, LP | 1,003,313 | 53,968,000 | 3.49% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 948,684 | 51,030,000 | 3.30% | ||
| 10 | BlackRock Fund Advisors | 946,458 | 50,910,000 | 3.30% | ||
| 11 | STATE STREET CORP | 807,331 | 43,428,000 | 2.81% | ||
| 12 | WASATCH ADVISORS LP | 791,542 | 42,577,000 | 2.76% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 686,198 | 36,911,000 | 2.39% | ||
| 14 | Sarissa Capital Management LP | 675,000 | 36,308,000 | 2.35% | ||
| 15 | BAKER BROS. ADVISORS LP | 609,166 | 32,767,000 | 2.12% | ||
| 16 | FRANKLIN RESOURCES INC | 451,900 | 24,308,000 | 1.57% | ||
| 17 | BlackRock Group LTD | 439,480 | 23,639,000 | 1.53% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 363,471 | 19,551,000 | 1.27% | ||
| 19 | MORGAN STANLEY | 356,193 | 19,160,000 | 1.24% | ||
| 20 | SENZAR ASSET MANAGEMENT, LLC | 352,924 | 18,983,782 | 1.23% | ||
| 21 | LOOMIS SAYLES & CO L P | 351,573 | 18,911,000 | 1.22% | ||
| 22 | NORTHERN TRUST CORP | 316,448 | 17,022,000 | 1.10% | ||
| 23 | FRONTIER CAPITAL MANAGEMENT CO LLC | 308,694 | 16,605,000 | 1.08% | ||
| 24 | EverPoint Asset Management, LLC | 300,000 | 16,137,000 | 1.04% | ||
| 25 | GILDER GAGNON HOWE & CO LLC | 298,423 | 16,052,000 | 1.04% | ||
| 26 | CLOUGH CAPITAL PARTNERS L P | 208,600 | 11,221,000 | 0.73% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 193,635 | 10,415,000 | 0.67% | ||
| 28 | Tekla Capital Management LLC | 187,800 | 10,102,000 | 0.65% | ||
| 29 | LORD, ABBETT & CO. LLC | 186,033 | 10,007,000 | 0.65% | ||
| 30 | Rock Springs Capital Management LP | 180,000 | 9,682,000 | 0.63% | ||
| 31 | Bank of New York Mellon Corp | 168,121 | 9,043,000 | 0.59% | ||
| 32 | Point72 Asset Management, L.P. | 164,200 | 8,832,000 | 0.57% | ||
| 33 | Allianz Asset Management GmbH | 163,336 | 8,786,000 | 0.57% | ||
| 34 | BlackRock Investment Management, LLC | 156,141 | 8,399,000 | 0.54% | ||
| 35 | Invesco Ltd. | 136,875 | 7,363,000 | 0.48% | ||
| 36 | Candriam S.C.A. | 136,200 | 7,326,000 | 0.47% | ||
| 37 | Rhenman & Partners Asset Management AB | 126,000 | 6,778,000 | 0.44% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 125,000 | 6,724,000 | 0.44% | Put | |
| 39 | C WorldWide Group Holding A/S | 124,000 | 6,670,000 | 0.43% | ||
| 40 | Weiss Multi-Strategy Advisers LLC | 114,000 | 6,132,000 | 0.40% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 110,270 | 5,931,000 | 0.38% | ||
| 42 | Informed Momentum Co LLC | 106,243 | 5,715,000 | 0.37% | ||
| 43 | DRIEHAUS CAPITAL MANAGEMENT LLC | 103,147 | 5,548,000 | 0.36% | ||
| 44 | BlackRock Finance, Inc. | 101,526 | 5,461,000 | 0.35% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 95,128 | 5,117,000 | 0.33% | ||
| 46 | WADDELL & REED FINANCIAL INC | 92,000 | 4,949,000 | 0.32% | ||
| 47 | SEI INVESTMENTS CO | 84,389 | 4,539,000 | 0.29% | ||
| 48 | Cupps Capital Management, LLC | 79,324 | 4,266,000 | 0.28% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 78,700 | 4,233,000 | 0.27% | ||
| 50 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 77,175 | 4,151,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
