| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,488,081 | 98,878,000 | 21.95% | ||
| 2 | VANGUARD GROUP INC | 2,459,371 | 37,481,000 | 8.32% | ||
| 3 | TimesSquare Capital Management, LLC | 1,756,575 | 26,770,000 | 5.94% | ||
| 4 | BB BIOTECH AG | 1,350,000 | 20,574,000 | 4.57% | ||
| 5 | JENNISON ASSOCIATES LLC | 1,313,516 | 20,018,000 | 4.44% | ||
| 6 | BlackRock Fund Advisors | 1,095,218 | 16,691,000 | 3.71% | ||
| 7 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 1,000,000 | 15,240,000 | 3.38% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 836,751 | 12,752,000 | 2.83% | ||
| 9 | STATE STREET CORP | 824,123 | 12,562,000 | 2.79% | ||
| 10 | WASATCH ADVISORS LP | 756,011 | 11,522,000 | 2.56% | ||
| 11 | Sarissa Capital Management LP | 675,000 | 10,286,000 | 2.28% | ||
| 12 | BAKER BROS. ADVISORS LP | 609,166 | 9,284,000 | 2.06% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 9,144,000 | 2.03% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 563,702 | 8,591,000 | 1.91% | ||
| 15 | BARCLAYS PLC | 490,200 | 7,471,000 | 1.66% | Call | |
| 16 | MORGAN STANLEY | 445,832 | 6,793,000 | 1.51% | ||
| 17 | NORTHERN TRUST CORP | 394,617 | 6,014,000 | 1.34% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 390,650 | 5,954,000 | 1.32% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 381,203 | 5,810,000 | 1.29% | ||
| 20 | Redmile Group, LLC | 336,759 | 5,132,000 | 1.14% | ||
| 21 | BLACKROCK ADVISORS LLC | 284,590 | 4,337,000 | 0.96% | ||
| 22 | NORGES BANK | 280,850 | 4,088,000 | 0.91% | ||
| 23 | GOLDMAN SACHS GROUP INC | 264,360 | 4,029,000 | 0.89% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 246,992 | 3,764,000 | 0.84% | ||
| 25 | JENNISON ASSOCIATES LLC | 241,800 | 3,685,000 | 0.82% | Put | |
| 26 | EverPoint Asset Management, LLC | 200,000 | 3,048,000 | 0.68% | ||
| 27 | Spark Investment Management LLC | 199,900 | 3,046,000 | 0.68% | ||
| 28 | Rock Springs Capital Management LP | 190,000 | 2,896,000 | 0.64% | ||
| 29 | BARCLAYS PLC | 180,000 | 2,743,000 | 0.61% | Put | |
| 30 | DEUTSCHE BANK AG\ | 174,315 | 2,654,000 | 0.59% | ||
| 31 | CLOUGH CAPITAL PARTNERS L P | 171,850 | 2,619,000 | 0.58% | ||
| 32 | Bank of New York Mellon Corp | 158,199 | 2,411,000 | 0.54% | ||
| 33 | Point72 Asset Management, L.P. | 153,300 | 2,336,000 | 0.52% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 150,000 | 2,286,000 | 0.51% | Put | |
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 148,931 | 2,270,000 | 0.50% | ||
| 36 | BlackRock Investment Management, LLC | 144,534 | 2,203,000 | 0.49% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,000 | 2,073,000 | 0.46% | Call | |
| 38 | Rhenman & Partners Asset Management AB | 135,000 | 2,057,400 | 0.46% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,931 | 1,889,000 | 0.42% | ||
| 40 | SEI INVESTMENTS CO | 113,548 | 1,730,000 | 0.38% | ||
| 41 | Candriam S.C.A. | 110,000 | 1,676,000 | 0.37% | ||
| 42 | PICTET ASSET MANAGEMENT LTD | 107,648 | 1,641,000 | 0.36% | ||
| 43 | FRONTIER CAPITAL MANAGEMENT CO LLC | 106,581 | 1,624,000 | 0.36% | ||
| 44 | SIMPLEX TRADING, LLC | 103,463 | 1,576,000 | 0.35% | ||
| 45 | WADDELL & REED FINANCIAL INC | 94,500 | 1,441,000 | 0.32% | ||
| 46 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 91,775 | 1,399,000 | 0.31% | ||
| 47 | ORBIMED ADVISORS LLC | 90,000 | 1,373,000 | 0.30% | Call | |
| 48 | ESSEX INVESTMENT MANAGEMENT CO LLC | 84,488 | 1,288,000 | 0.29% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,665 | 1,107,000 | 0.25% | ||
| 50 | ALPINE WOODS CAPITAL INVESTORS, LLC | 70,544 | 1,075,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
