| 1 |
FMR LLC |
4,408,008 |
60,434,000 |
36.44% |
|
|
| 2 |
Redmile Group, LLC |
1,003,496 |
13,758,000 |
8.30% |
|
|
| 3 |
BLACKROCK ADVISORS LLC |
975,165 |
13,369,000 |
8.06% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
750,000 |
10,283,000 |
6.20% |
|
|
| 5 |
Visium Asset Management, LP |
700,556 |
9,605,000 |
5.79% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
559,800 |
7,675,000 |
4.63% |
|
|
| 7 |
BlackRock Fund Advisors |
405,346 |
5,557,000 |
3.35% |
|
|
| 8 |
VANGUARD GROUP INC |
404,908 |
5,551,000 |
3.35% |
|
|
| 9 |
WALL STREET ASSOCIATES |
371,957 |
5,100,000 |
3.08% |
|
|
| 10 |
Sarissa Capital Management LP |
360,000 |
4,936,000 |
2.98% |
|
|
| 11 |
BlackRock Group LTD |
340,933 |
4,674,000 |
2.82% |
|
|
| 12 |
MORGAN STANLEY |
228,001 |
3,126,000 |
1.89% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
186,461 |
2,556,000 |
1.54% |
|
|
| 14 |
NORTHERN TRUST CORP |
185,043 |
2,537,000 |
1.53% |
|
|
| 15 |
STATE STREET CORP |
177,120 |
2,428,000 |
1.46% |
|
|
| 16 |
Rhenman & Partners Asset Management AB |
149,000 |
2,043,000 |
1.23% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
111,756 |
1,532,000 |
0.92% |
|
|
| 18 |
BlackRock Investment Management, LLC |
109,955 |
1,507,000 |
0.91% |
|
|
| 19 |
BlackRock Finance, Inc. |
97,314 |
1,334,000 |
0.80% |
|
|
| 20 |
Bank of New York Mellon Corp |
86,737 |
1,189,000 |
0.72% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,725 |
887,000 |
0.53% |
|
|
| 22 |
Alyeska Investment Group, L.P. |
59,995 |
823,000 |
0.50% |
|
|
| 23 |
Weiss Multi-Strategy Advisers LLC |
57,945 |
794,000 |
0.48% |
|
|
| 24 |
State of New Jersey Common Pension Fund D |
45,000 |
617,000 |
0.37% |
|
|
| 25 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
44,931 |
617,000 |
0.37% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
31,579 |
433,000 |
0.26% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
24,080 |
330,000 |
0.20% |
|
|
| 28 |
METROPOLITAN LIFE INSURANCE CO/NY |
18,580 |
255,000 |
0.15% |
|
|
| 29 |
DEUTSCHE BANK AG\ |
17,223 |
235,000 |
0.14% |
|
|
| 30 |
Swiss National Bank |
17,000 |
233,000 |
0.14% |
|
|
| 31 |
Nationwide Fund Advisors |
13,101 |
180,000 |
0.11% |
|
|
| 32 |
VOYA INVESTMENT MANAGEMENT LLC |
12,331 |
169,000 |
0.10% |
|
|
| 33 |
Stifel Trust Company, N.A. |
12,000 |
165,000 |
0.10% |
|
|
| 34 |
RHUMBLINE ADVISERS |
11,730 |
161,000 |
0.10% |
|
|
| 35 |
AMERICAN INTERNATIONAL GROUP, INC. |
11,178 |
153,250 |
0.09% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,938 |
150,000 |
0.09% |
|
|
| 37 |
GOLDMAN SACHS GROUP INC |
10,881 |
149,000 |
0.09% |
|
|
| 38 |
Tower Research Capital LLC (TRC) |
9,152 |
125,000 |
0.08% |
|
|
| 39 |
Legal & General Group Plc |
3,343 |
48,000 |
0.03% |
|
|
| 40 |
STRS OHIO |
2,370 |
32,000 |
0.02% |
|
|
| 41 |
ALLIANCEBERNSTEIN L.P. |
1,700 |
23,000 |
0.01% |
|
|
| 42 |
BNP PARIBAS FINANCIAL MARKETS |
1,023 |
14,025 |
0.01% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
787 |
11,000 |
0.01% |
|
|
| 44 |
TEACHER RETIREMENT SYSTEM OF TEXAS |
704 |
10,000 |
0.01% |
|
|
| 45 |
CITIGROUP INC |
594 |
8,000 |
0.00% |
|
|
| 46 |
Ground Swell Capital, LLC |
615 |
8,000 |
0.00% |
|
|
| 47 |
BARCLAYS PLC |
594 |
7,000 |
0.00% |
|
|
| 48 |
BANK OF AMERICA CORP /DE/ |
177 |
2,000 |
0.00% |
|
|
| 49 |
AMERIPRISE FINANCIAL INC |
5 |
0 |
0.00% |
|
|
