| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,245,175 | 167,583,000 | 28.85% | ||
| 2 | WASATCH ADVISORS LP | 1,128,871 | 36,067,000 | 6.21% | ||
| 3 | Visium Asset Management, LP | 1,051,479 | 33,595,000 | 5.78% | ||
| 4 | BlackRock Fund Advisors | 991,786 | 31,688,000 | 5.45% | ||
| 5 | VANGUARD GROUP INC | 723,993 | 23,132,000 | 3.98% | ||
| 6 | BLACKROCK ADVISORS LLC | 710,660 | 22,706,000 | 3.91% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 22,365,000 | 3.85% | ||
| 8 | Redmile Group, LLC | 610,171 | 19,495,000 | 3.36% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 515,689 | 16,476,000 | 2.84% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 493,044 | 15,753,000 | 2.71% | ||
| 11 | MORGAN STANLEY | 378,210 | 12,083,000 | 2.08% | ||
| 12 | FRANKLIN RESOURCES INC | 366,700 | 11,716,000 | 2.02% | ||
| 13 | Sarissa Capital Management LP | 360,000 | 11,502,000 | 1.98% | ||
| 14 | WALL STREET ASSOCIATES | 358,857 | 11,465,000 | 1.97% | ||
| 15 | STATE STREET CORP | 300,974 | 9,617,000 | 1.66% | ||
| 16 | EverPoint Asset Management, LLC | 300,000 | 9,585,000 | 1.65% | ||
| 17 | Pier Capital, LLC | 257,256 | 8,219,000 | 1.41% | ||
| 18 | NORTHERN TRUST CORP | 233,588 | 7,463,000 | 1.28% | ||
| 19 | Tekla Capital Management LLC | 227,164 | 7,258,000 | 1.25% | ||
| 20 | CLOUGH CAPITAL PARTNERS L P | 221,800 | 7,087,000 | 1.22% | ||
| 21 | Rhenman & Partners Asset Management AB | 206,000 | 6,582,000 | 1.13% | ||
| 22 | Candriam S.C.A. | 172,000 | 5,495,000 | 0.95% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 164,990 | 5,271,000 | 0.91% | ||
| 24 | SENZAR ASSET MANAGEMENT, LLC | 161,300 | 5,154,000 | 0.89% | ||
| 25 | Informed Momentum Co LLC | 152,389 | 4,869,000 | 0.84% | ||
| 26 | Bank of New York Mellon Corp | 151,429 | 4,838,000 | 0.83% | ||
| 27 | BlackRock Group LTD | 139,697 | 4,463,000 | 0.77% | ||
| 28 | SPHERA FUNDS MANAGEMENT LTD. | 128,000 | 4,090,000 | 0.70% | ||
| 29 | BlackRock Investment Management, LLC | 120,602 | 3,853,000 | 0.66% | ||
| 30 | Point72 Asset Management, L.P. | 114,100 | 3,645,000 | 0.63% | ||
| 31 | BAKER BROS. ADVISORS LP | 104,166 | 3,328,000 | 0.57% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 94,514 | 3,020,000 | 0.52% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 75,400 | 2,409,000 | 0.41% | Call | |
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 73,123 | 2,337,000 | 0.40% | ||
| 35 | RUSSELL FRANK CO/ | 66,503 | 2,125,000 | 0.37% | ||
| 36 | GOLDMAN SACHS GROUP INC | 51,708 | 1,652,000 | 0.28% | ||
| 37 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 50,000 | 1,598,000 | 0.28% | ||
| 38 | EDMOND DE ROTHSCHILD HOLDING S.A. | 50,000 | 1,598,000 | 0.28% | ||
| 39 | BALYASNY ASSET MANAGEMENT L.P. | 50,000 | 1,598,000 | 0.28% | ||
| 40 | AMERIPRISE FINANCIAL INC | 47,720 | 1,525,000 | 0.26% | ||
| 41 | State of New Jersey Common Pension Fund D | 45,000 | 1,438,000 | 0.25% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,500 | 1,294,000 | 0.22% | Put | |
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,629 | 1,266,000 | 0.22% | ||
| 44 | BlackRock Finance, Inc. | 39,114 | 1,249,000 | 0.21% | ||
| 45 | D. E. Shaw & Co., Inc. | 38,700 | 1,236,000 | 0.21% | ||
| 46 | TEACHERS ADVISORS, LLC | 35,925 | 1,148,000 | 0.20% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 34,000 | 1,086,000 | 0.19% | ||
| 48 | FRED ALGER MANAGEMENT, LLC | 32,450 | 1,037,000 | 0.18% | ||
| 49 | AQR CAPITAL MANAGEMENT LLC | 32,101 | 1,026,000 | 0.18% | ||
| 50 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 29,260 | 935,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
