| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,490,236 | 97,938,000 | 21.31% | ||
| 2 | VANGUARD GROUP INC | 2,555,722 | 38,565,000 | 8.39% | ||
| 3 | BlackRock Fund Advisors | 2,034,263 | 30,697,000 | 6.68% | ||
| 4 | BB BIOTECH AG | 1,575,000 | 23,767,000 | 5.17% | ||
| 5 | TimesSquare Capital Management, LLC | 1,534,938 | 23,162,000 | 5.04% | ||
| 6 | CITADEL ADVISORS LLC | 1,263,482 | 19,066,000 | 4.15% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,024,366 | 15,458,000 | 3.36% | ||
| 8 | WASATCH ADVISORS LP | 1,014,948 | 15,316,000 | 3.33% | ||
| 9 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 1,000,000 | 15,090,000 | 3.28% | ||
| 10 | STATE STREET CORP | 972,868 | 14,686,000 | 3.20% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 940,753 | 14,196,000 | 3.09% | ||
| 12 | BAKER BROS. ADVISORS LP | 609,166 | 9,192,000 | 2.00% | ||
| 13 | COLUMBUS CIRCLE INVESTORS | 519,108 | 7,833,000 | 1.70% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 516,622 | 7,796,000 | 1.70% | ||
| 15 | MORGAN STANLEY | 491,844 | 7,421,000 | 1.61% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 486,493 | 7,341,000 | 1.60% | ||
| 17 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 453,534 | 6,843,000 | 1.49% | ||
| 18 | NORTHERN TRUST CORP | 406,619 | 6,137,000 | 1.34% | ||
| 19 | DEUTSCHE BANK AG\ | 382,734 | 5,774,000 | 1.26% | ||
| 20 | Sarissa Capital Management LP | 360,000 | 5,432,000 | 1.18% | ||
| 21 | CLOUGH CAPITAL PARTNERS L P | 349,650 | 5,276,000 | 1.15% | ||
| 22 | Rhenman & Partners Asset Management AB | 290,000 | 4,376,000 | 0.95% | ||
| 23 | BLACKROCK ADVISORS LLC | 287,051 | 4,332,000 | 0.94% | ||
| 24 | NORGES BANK | 280,850 | 4,238,000 | 0.92% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 262,759 | 3,965,000 | 0.86% | ||
| 26 | Rock Springs Capital Management LP | 190,000 | 2,867,000 | 0.62% | ||
| 27 | Weiss Multi-Strategy Advisers LLC | 180,000 | 2,716,000 | 0.59% | ||
| 28 | Bank of New York Mellon Corp | 147,720 | 2,229,000 | 0.49% | ||
| 29 | BlackRock Investment Management, LLC | 144,713 | 2,184,000 | 0.48% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 142,259 | 2,147,000 | 0.47% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 139,500 | 2,105,000 | 0.46% | Call | |
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 130,640 | 1,972,000 | 0.43% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 123,108 | 1,858,000 | 0.40% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 120,263 | 1,815,000 | 0.39% | ||
| 35 | D. E. Shaw & Co., Inc. | 118,390 | 1,786,000 | 0.39% | ||
| 36 | Candriam S.C.A. | 117,000 | 1,765,000 | 0.38% | ||
| 37 | SEI INVESTMENTS CO | 112,000 | 1,690,000 | 0.37% | ||
| 38 | FRONTIER CAPITAL MANAGEMENT CO LLC | 100,184 | 1,512,000 | 0.33% | ||
| 39 | A.R.T. Advisors, LLC | 99,300 | 1,498,000 | 0.33% | ||
| 40 | C WorldWide Group Holding A/S | 96,048 | 1,449,000 | 0.32% | ||
| 41 | JPMORGAN CHASE & CO | 95,539 | 1,441,000 | 0.31% | ||
| 42 | WELLS FARGO & COMPANY/MN | 94,889 | 1,431,000 | 0.31% | ||
| 43 | PDT Partners, LLC | 91,357 | 1,379,000 | 0.30% | ||
| 44 | GOLDMAN SACHS GROUP INC | 83,300 | 1,257,000 | 0.27% | ||
| 45 | ALPINE WOODS CAPITAL INVESTORS, LLC | 73,944 | 1,116,000 | 0.24% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,100 | 1,088,000 | 0.24% | Put | |
| 47 | TEACHERS ADVISORS, LLC | 70,948 | 1,071,000 | 0.23% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 70,765 | 1,068,000 | 0.23% | ||
| 49 | Numeric Investors LLC | 67,909 | 1,025,000 | 0.22% | ||
| 50 | State of New Jersey Common Pension Fund D | 62,500 | 943,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
