| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,287,661 | 251,758,000 | 22.07% | ||
| 2 | Redmile Group, LLC | 1,322,592 | 52,957,000 | 4.64% | ||
| 3 | STATE STREET CORP | 1,180,210 | 47,253,000 | 4.14% | ||
| 4 | BLACKROCK ADVISORS LLC | 1,179,105 | 47,212,000 | 4.14% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,145,766 | 45,876,000 | 4.02% | ||
| 6 | TimesSquare Capital Management, LLC | 1,100,000 | 44,044,000 | 3.86% | ||
| 7 | WASATCH ADVISORS LP | 1,085,973 | 43,482,000 | 3.81% | ||
| 8 | Visium Asset Management, LP | 990,379 | 39,655,000 | 3.48% | ||
| 9 | VANGUARD GROUP INC | 961,131 | 38,484,000 | 3.37% | ||
| 10 | BlackRock Fund Advisors | 886,797 | 35,507,000 | 3.11% | ||
| 11 | Sarissa Capital Management LP | 640,000 | 25,626,000 | 2.25% | ||
| 12 | BAKER BROS. ADVISORS LP | 609,166 | 24,391,000 | 2.14% | ||
| 13 | MORGAN STANLEY | 572,855 | 22,937,000 | 2.01% | ||
| 14 | SENZAR ASSET MANAGEMENT, LLC | 556,224 | 22,271,209 | 1.95% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 550,758 | 22,052,000 | 1.93% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 494,812 | 19,812,000 | 1.74% | ||
| 17 | FRANKLIN RESOURCES INC | 467,500 | 18,719,000 | 1.64% | ||
| 18 | BlackRock Group LTD | 427,751 | 17,127,000 | 1.50% | ||
| 19 | JENNISON ASSOCIATES LLC | 402,000 | 16,096,000 | 1.41% | ||
| 20 | HIGHLAND CAPITAL MANAGEMENT LP | 396,982 | 15,895,000 | 1.39% | ||
| 21 | RA CAPITAL MANAGEMENT, L.P. | 314,349 | 12,587,000 | 1.10% | ||
| 22 | GILDER GAGNON HOWE & CO LLC | 301,656 | 12,078,000 | 1.06% | ||
| 23 | CLOUGH CAPITAL PARTNERS L P | 279,000 | 11,171,000 | 0.98% | ||
| 24 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 254,176 | 10,177,000 | 0.89% | ||
| 25 | NORTHERN TRUST CORP | 251,537 | 10,071,000 | 0.88% | ||
| 26 | COLUMBUS CIRCLE INVESTORS | 244,842 | 9,803,000 | 0.86% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 225,400 | 9,025,000 | 0.79% | Call | |
| 28 | EverPoint Asset Management, LLC | 225,000 | 9,009,000 | 0.79% | ||
| 29 | LOOMIS SAYLES & CO L P | 217,189 | 8,696,000 | 0.76% | ||
| 30 | WALL STREET ASSOCIATES | 205,657 | 8,235,000 | 0.72% | ||
| 31 | Allianz Asset Management GmbH | 192,238 | 7,697,000 | 0.67% | ||
| 32 | BARCLAYS PLC | 185,700 | 7,428,000 | 0.65% | Put | |
| 33 | RENAISSANCE TECHNOLOGIES LLC | 183,091 | 7,331,000 | 0.64% | ||
| 34 | Rock Springs Capital Management LP | 180,000 | 7,207,000 | 0.63% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 168,323 | 6,739,000 | 0.59% | ||
| 36 | Rhenman & Partners Asset Management AB | 165,000 | 6,607,000 | 0.58% | ||
| 37 | Tekla Capital Management LLC | 150,000 | 6,006,000 | 0.53% | ||
| 38 | BlackRock Investment Management, LLC | 145,639 | 5,831,000 | 0.51% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,800 | 5,477,000 | 0.48% | Put | |
| 40 | LORD, ABBETT & CO. LLC | 136,119 | 5,450,000 | 0.48% | ||
| 41 | Bank of New York Mellon Corp | 135,651 | 5,431,000 | 0.48% | ||
| 42 | Invesco Ltd. | 130,389 | 5,221,000 | 0.46% | ||
| 43 | WADDELL & REED FINANCIAL INC | 126,800 | 5,077,000 | 0.45% | ||
| 44 | Candriam S.C.A. | 116,200 | 4,653,000 | 0.41% | ||
| 45 | BlackRock Finance, Inc. | 116,014 | 4,646,000 | 0.41% | ||
| 46 | Weiss Multi-Strategy Advisers LLC | 114,000 | 4,565,000 | 0.40% | ||
| 47 | DEUTSCHE BANK AG\ | 109,715 | 4,392,000 | 0.39% | ||
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 105,400 | 4,220,000 | 0.37% | ||
| 49 | Laurion Capital Management LP | 95,700 | 3,832,000 | 0.34% | ||
| 50 | Informed Momentum Co LLC | 95,168 | 3,811,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
