| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,476,306 | 180,041,000 | 21.88% | ||
| 2 | VANGUARD GROUP INC | 1,574,163 | 43,761,000 | 5.32% | ||
| 3 | TimesSquare Capital Management, LLC | 1,524,375 | 42,378,000 | 5.15% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,277,610 | 35,518,000 | 4.32% | ||
| 5 | BLACKROCK ADVISORS LLC | 1,269,972 | 35,305,000 | 4.29% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 1,234,030 | 34,306,000 | 4.17% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,100,000 | 30,580,000 | 3.72% | ||
| 8 | Redmile Group, LLC | 1,056,059 | 29,358,000 | 3.57% | ||
| 9 | BlackRock Fund Advisors | 970,940 | 26,992,000 | 3.28% | ||
| 10 | Visium Asset Management, LP | 879,969 | 24,464,000 | 2.97% | ||
| 11 | STATE STREET CORP | 831,297 | 23,112,000 | 2.81% | ||
| 12 | WASATCH ADVISORS LP | 801,036 | 22,189,000 | 2.70% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 721,394 | 20,055,000 | 2.44% | ||
| 14 | Sarissa Capital Management LP | 675,000 | 18,764,000 | 2.28% | ||
| 15 | EverPoint Asset Management, LLC | 650,000 | 18,070,000 | 2.20% | ||
| 16 | BAKER BROS. ADVISORS LP | 609,166 | 16,935,000 | 2.06% | ||
| 17 | BlackRock Group LTD | 485,807 | 13,506,000 | 1.64% | ||
| 18 | MORGAN STANLEY | 405,482 | 11,271,000 | 1.37% | ||
| 19 | COLUMBUS CIRCLE INVESTORS | 394,606 | 10,970,000 | 1.33% | ||
| 20 | SENZAR ASSET MANAGEMENT, LLC | 382,924 | 10,645,287 | 1.29% | ||
| 21 | NORTHERN TRUST CORP | 320,115 | 8,900,000 | 1.08% | ||
| 22 | ORBIMED ADVISORS LLC | 294,000 | 8,173,000 | 0.99% | ||
| 23 | GILDER GAGNON HOWE & CO LLC | 291,332 | 8,099,000 | 0.98% | ||
| 24 | FRANKLIN RESOURCES INC | 253,000 | 7,033,000 | 0.85% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 233,900 | 6,502,000 | 0.79% | ||
| 26 | Point72 Asset Management, L.P. | 230,600 | 6,411,000 | 0.78% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 204,936 | 5,697,000 | 0.69% | ||
| 28 | CLOUGH CAPITAL PARTNERS L P | 200,050 | 5,561,000 | 0.68% | ||
| 29 | FRONTIER CAPITAL MANAGEMENT CO LLC | 193,614 | 5,382,000 | 0.65% | ||
| 30 | Tekla Capital Management LLC | 187,800 | 5,221,000 | 0.63% | ||
| 31 | Rock Springs Capital Management LP | 187,500 | 5,213,000 | 0.63% | ||
| 32 | BlackRock Investment Management, LLC | 167,595 | 4,659,000 | 0.57% | ||
| 33 | Weiss Multi-Strategy Advisers LLC | 156,500 | 4,351,000 | 0.53% | ||
| 34 | LORD, ABBETT & CO. LLC | 151,264 | 4,206,000 | 0.51% | ||
| 35 | Bank of New York Mellon Corp | 148,850 | 4,138,000 | 0.50% | ||
| 36 | Candriam S.C.A. | 134,000 | 3,705,000 | 0.45% | ||
| 37 | C WorldWide Group Holding A/S | 125,500 | 3,489,000 | 0.42% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 125,515 | 3,489,000 | 0.42% | ||
| 39 | Rhenman & Partners Asset Management AB | 115,000 | 3,197,000 | 0.39% | ||
| 40 | BlackRock Finance, Inc. | 102,574 | 2,852,000 | 0.35% | ||
| 41 | SEI INVESTMENTS CO | 100,814 | 2,803,000 | 0.34% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 100,000 | 2,780,000 | 0.34% | Put | |
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 97,165 | 2,702,000 | 0.33% | ||
| 44 | WADDELL & REED FINANCIAL INC | 92,000 | 2,557,000 | 0.31% | ||
| 45 | DRIEHAUS CAPITAL MANAGEMENT LLC | 91,796 | 2,552,000 | 0.31% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,100 | 2,171,000 | 0.26% | Put | |
| 47 | SABBY MANAGEMENT, LLC | 78,000 | 2,168,000 | 0.26% | ||
| 48 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 77,675 | 2,159,000 | 0.26% | ||
| 49 | Invesco Ltd. | 66,475 | 1,848,000 | 0.22% | ||
| 50 | State of New Jersey Common Pension Fund D | 62,500 | 1,738,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
