| 1 |
FMR LLC |
4,409,575 |
77,829,000 |
36.10% |
|
|
| 2 |
Redmile Group, LLC |
990,810 |
17,488,000 |
8.11% |
|
|
| 3 |
BLACKROCK ADVISORS LLC |
971,240 |
17,142,000 |
7.95% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
800,000 |
14,120,000 |
6.55% |
|
|
| 5 |
Visium Asset Management, LP |
701,419 |
12,381,000 |
5.74% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
498,900 |
8,806,000 |
4.08% |
|
|
| 7 |
BlackRock Fund Advisors |
478,734 |
8,450,000 |
3.92% |
|
|
| 8 |
VANGUARD GROUP INC |
449,003 |
7,925,000 |
3.68% |
|
|
| 9 |
WALL STREET ASSOCIATES |
370,757 |
6,544,000 |
3.04% |
|
|
| 10 |
Sarissa Capital Management LP |
360,000 |
6,354,000 |
2.95% |
|
|
| 11 |
BlackRock Group LTD |
340,933 |
6,017,000 |
2.79% |
|
|
| 12 |
MORGAN STANLEY |
257,850 |
4,551,000 |
2.11% |
|
|
| 13 |
STATE STREET CORP |
192,941 |
3,404,000 |
1.58% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
185,257 |
3,270,000 |
1.52% |
|
|
| 15 |
NORTHERN TRUST CORP |
179,147 |
3,162,000 |
1.47% |
|
|
| 16 |
Rhenman & Partners Asset Management AB |
159,854 |
2,821,000 |
1.31% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
114,734 |
2,025,000 |
0.94% |
|
|
| 18 |
BlackRock Investment Management, LLC |
109,390 |
1,931,000 |
0.90% |
|
|
| 19 |
BlackRock Finance, Inc. |
97,314 |
1,717,000 |
0.80% |
|
|
| 20 |
Bank of New York Mellon Corp |
85,158 |
1,503,000 |
0.70% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
66,522 |
1,174,000 |
0.54% |
|
|
| 22 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
60,699 |
1,072,000 |
0.50% |
|
|
| 23 |
Alyeska Investment Group, L.P. |
57,853 |
1,021,000 |
0.47% |
|
|
| 24 |
State of New Jersey Common Pension Fund D |
45,000 |
794,000 |
0.37% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
31,714 |
560,000 |
0.26% |
|
|
| 26 |
Weiss Multi-Strategy Advisers LLC |
25,000 |
441,000 |
0.20% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
24,080 |
425,000 |
0.20% |
|
|
| 28 |
METROPOLITAN LIFE INSURANCE CO/NY |
17,408 |
307,000 |
0.14% |
|
|
| 29 |
Swiss National Bank |
17,000 |
300,000 |
0.14% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
14,531 |
255,000 |
0.12% |
|
|
| 31 |
Nationwide Fund Advisors |
12,932 |
228,000 |
0.11% |
|
|
| 32 |
STIFEL FINANCIAL CORP |
12,300 |
218,000 |
0.10% |
|
|
| 33 |
VOYA INVESTMENT MANAGEMENT LLC |
12,331 |
218,000 |
0.10% |
|
|
| 34 |
RHUMBLINE ADVISERS |
12,155 |
215,000 |
0.10% |
|
|
| 35 |
NORTHERN CAPITAL MANAGEMENT LLC |
12,175 |
215,000 |
0.10% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,938 |
193,000 |
0.09% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,751 |
189,755 |
0.09% |
|
|
| 38 |
CITIGROUP INC |
4,935 |
87,000 |
0.04% |
|
|
| 39 |
Legal & General Group Plc |
3,343 |
60,000 |
0.03% |
|
|
| 40 |
BARCLAYS PLC |
3,315 |
57,000 |
0.03% |
|
|
| 41 |
B. Riley Wealth Advisors, Inc. |
2,500 |
44,000 |
0.02% |
|
|
| 42 |
ALLIANCEBERNSTEIN L.P. |
1,400 |
25,000 |
0.01% |
|
|
| 43 |
UBS Group AG |
1,294 |
23,000 |
0.01% |
|
|
| 44 |
Blume Capital Management, Inc. |
1,000 |
18,000 |
0.01% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
793 |
14,000 |
0.01% |
|
|
| 46 |
TEACHER RETIREMENT SYSTEM OF TEXAS |
576 |
10,000 |
0.00% |
|
|
| 47 |
Tower Research Capital LLC (TRC) |
200 |
4,000 |
0.00% |
|
|
