| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,380,074 | 47,601,000 | 29.30% | ||
| 2 | FMR LLC | 1,214,275 | 24,286,000 | 14.95% | ||
| 3 | ORBIMED ADVISORS LLC | 1,172,000 | 23,440,000 | 14.43% | ||
| 4 | FRANKLIN RESOURCES INC | 1,032,246 | 20,645,000 | 12.71% | ||
| 5 | QVT Financial LP | 507,184 | 9,949,000 | 6.12% | ||
| 6 | TANG CAPITAL MANAGEMENT LLC | 288,432 | 5,769,000 | 3.55% | ||
| 7 | Artal Group S.A. | 250,000 | 5,000,000 | 3.08% | ||
| 8 | VANGUARD GROUP INC | 210,098 | 4,202,000 | 2.59% | ||
| 9 | Broadfin Capital, LLC | 184,756 | 3,695,000 | 2.27% | ||
| 10 | BlackRock Fund Advisors | 176,550 | 3,531,000 | 2.17% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 163,675 | 3,274,000 | 2.01% | ||
| 12 | First Eagle Investment Management, LLC | 99,912 | 1,998,000 | 1.23% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 60,564 | 1,211,000 | 0.75% | ||
| 14 | STATE STREET CORP | 57,743 | 1,155,000 | 0.71% | ||
| 15 | GOLDMAN SACHS GROUP INC | 49,849 | 997,000 | 0.61% | ||
| 16 | BAILARD, INC. | 34,000 | 680,000 | 0.42% | ||
| 17 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,630 | 553,000 | 0.34% | ||
| 18 | Bank of New York Mellon Corp | 21,175 | 424,000 | 0.26% | ||
| 19 | MORGAN STANLEY | 20,945 | 419,000 | 0.26% | ||
| 20 | DEUTSCHE BANK AG\ | 20,335 | 406,000 | 0.25% | ||
| 21 | BlackRock Investment Management, LLC | 19,915 | 398,000 | 0.24% | ||
| 22 | UBS AG | 14,612 | 292,000 | 0.18% | ||
| 23 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,100 | 262,000 | 0.16% | ||
| 24 | JANE STREET GROUP, LLC | 12,201 | 244,000 | 0.15% | ||
| 25 | Spark Investment Management LLC | 11,600 | 231,000 | 0.14% | ||
| 26 | TWO SIGMA INVESTMENTS, LP | 11,279 | 226,000 | 0.14% | ||
| 27 | A.R.T. Advisors, LLC | 10,931 | 218,000 | 0.13% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,500 | 210,000 | 0.13% | ||
| 29 | TEACHERS ADVISORS, LLC | 10,258 | 205,000 | 0.13% | ||
| 30 | SG Americas Securities, LLC | 9,116 | 182,000 | 0.11% | ||
| 31 | ROYAL BANK OF CANADA | 9,002 | 180,000 | 0.11% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 5,479 | 110,000 | 0.07% | ||
| 33 | Nationwide Fund Advisors | 5,270 | 105,000 | 0.06% | ||
| 34 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,068 | 101,000 | 0.06% | ||
| 35 | AMERICAN INTERNATIONAL GROUP, INC. | 4,693 | 93,860 | 0.06% | ||
| 36 | BLACKROCK ADVISORS LLC | 2,975 | 60,000 | 0.04% | ||
| 37 | STRS OHIO | 2,400 | 48,000 | 0.03% | ||
| 38 | Tower Research Capital LLC (TRC) | 1,232 | 25,000 | 0.02% | ||
| 39 | WELLS FARGO & COMPANY/MN | 1,187 | 24,000 | 0.01% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 800 | 16,000 | 0.01% | ||
| 41 | VIRTUS CAPITAL ADVISERS, LLC | 612 | 12,000 | 0.01% | ||
| 42 | BARCLAYS PLC | 157 | 3,000 | 0.00% | ||
| 43 | B. Riley Wealth Management, Inc. | 82 | 1,000 | 0.00% | ||
| 44 | CITIGROUP INC | 61 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
