| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,955,074 | 93,380,000 | 18.66% | ||
| 2 | FMR LLC | 2,889,888 | 91,320,000 | 18.25% | ||
| 3 | BOXER CAPITAL, LLC | 2,023,232 | 63,934,000 | 12.77% | ||
| 4 | Avoro Capital Advisors LLC | 1,258,055 | 39,755,000 | 7.94% | ||
| 5 | FRANKLIN RESOURCES INC | 613,996 | 19,402,000 | 3.88% | ||
| 6 | VANGUARD GROUP INC | 533,891 | 16,871,000 | 3.37% | ||
| 7 | AVIVA HOLDINGS LTD. | 522,500 | 16,511,000 | 3.30% | ||
| 8 | Cormorant Asset Management, LP | 495,356 | 15,653,000 | 3.13% | ||
| 9 | Visium Asset Management, LP | 425,000 | 13,430,000 | 2.68% | ||
| 10 | RTW INVESTMENTS, LP | 378,287 | 11,954,000 | 2.39% | ||
| 11 | STATE STREET CORP | 369,596 | 11,678,000 | 2.33% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 338,770 | 10,705,000 | 2.14% | ||
| 13 | BlackRock Fund Advisors | 313,823 | 9,917,000 | 1.98% | ||
| 14 | QVT Financial LP | 251,137 | 7,936,000 | 1.59% | ||
| 15 | Ghost Tree Capital, LLC | 250,000 | 7,900,000 | 1.58% | ||
| 16 | Broadfin Capital, LLC | 235,870 | 7,453,000 | 1.49% | ||
| 17 | DEUTSCHE BANK AG\ | 185,347 | 5,856,000 | 1.17% | ||
| 18 | DRIEHAUS CAPITAL MANAGEMENT LLC | 176,473 | 5,577,000 | 1.11% | ||
| 19 | MORGAN STANLEY | 141,460 | 4,470,000 | 0.89% | ||
| 20 | NORTHERN TRUST CORP | 137,833 | 4,355,000 | 0.87% | ||
| 21 | Candriam S.C.A. | 115,000 | 3,634,000 | 0.73% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 104,648 | 3,306,000 | 0.66% | ||
| 23 | ACUTA CAPITAL PARTNERS, LLC | 88,439 | 2,795,000 | 0.56% | ||
| 24 | JPMORGAN CHASE & CO | 73,025 | 2,308,000 | 0.46% | ||
| 25 | JENNISON ASSOCIATES LLC | 65,254 | 2,062,000 | 0.41% | ||
| 26 | Bank of New York Mellon Corp | 56,028 | 1,771,000 | 0.35% | ||
| 27 | Rhenman & Partners Asset Management AB | 50,000 | 1,580,000 | 0.32% | ||
| 28 | BlackRock Investment Management, LLC | 39,742 | 1,256,000 | 0.25% | ||
| 29 | UBS Group AG | 39,095 | 1,235,000 | 0.25% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,400 | 1,182,000 | 0.24% | Put | |
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 35,395 | 1,118,000 | 0.22% | ||
| 32 | Spark Investment Management LLC | 32,566 | 1,029,000 | 0.21% | ||
| 33 | ORBIMED ADVISORS LLC | 32,200 | 1,018,000 | 0.20% | ||
| 34 | CITADEL ADVISORS LLC | 30,916 | 977,000 | 0.20% | ||
| 35 | Trexquant Investment LP | 29,900 | 945,000 | 0.19% | ||
| 36 | Informed Momentum Co LLC | 29,838 | 943,000 | 0.19% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 27,389 | 855,000 | 0.17% | ||
| 38 | SABBY MANAGEMENT, LLC | 26,027 | 822,000 | 0.16% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,345 | 801,000 | 0.16% | ||
| 40 | CREDIT SUISSE AG/ | 24,913 | 787,000 | 0.16% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 24,308 | 768,000 | 0.15% | ||
| 42 | RUSSELL FRANK CO/ | 24,343 | 743,000 | 0.15% | ||
| 43 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 21,950 | 694,000 | 0.14% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,291 | 673,000 | 0.13% | ||
| 45 | PDT Partners, LLC | 18,600 | 588,000 | 0.12% | ||
| 46 | Integre Asset Management, LLC | 18,411 | 582,000 | 0.12% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,048 | 571,000 | 0.11% | ||
| 48 | ArrowMark Colorado Holdings LLC | 17,122 | 541,000 | 0.11% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 16,700 | 528,000 | 0.11% | ||
| 50 | TEACHERS ADVISORS, LLC | 16,467 | 520,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
