| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,269,198 | 12,390,000 | 16.38% | ||
| 2 | AVIVA HOLDINGS LTD. | 1,992,085 | 10,877,000 | 14.38% | ||
| 3 | FMR LLC | 1,593,092 | 8,698,000 | 11.50% | ||
| 4 | Avoro Capital Advisors LLC | 1,214,833 | 6,633,000 | 8.77% | ||
| 5 | BOXER CAPITAL, LLC | 757,935 | 4,138,000 | 5.47% | ||
| 6 | Broadfin Capital, LLC | 693,863 | 3,788,000 | 5.01% | ||
| 7 | VANGUARD GROUP INC | 624,044 | 3,407,000 | 4.51% | ||
| 8 | FRANKLIN RESOURCES INC | 613,996 | 3,352,000 | 4.43% | ||
| 9 | QVT Financial LP | 509,750 | 2,783,000 | 3.68% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 358,068 | 1,955,000 | 2.59% | ||
| 11 | BlackRock Fund Advisors | 331,008 | 1,807,000 | 2.39% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 291,098 | 1,589,000 | 2.10% | ||
| 13 | DEUTSCHE BANK AG\ | 284,518 | 1,552,000 | 2.05% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 235,720 | 1,287,000 | 1.70% | ||
| 15 | STATE STREET CORP | 168,077 | 917,000 | 1.21% | ||
| 16 | NORTHERN TRUST CORP | 153,684 | 839,000 | 1.11% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 819,000 | 1.08% | ||
| 18 | RTW INVESTMENTS, LP | 131,052 | 716,000 | 0.95% | ||
| 19 | ACUTA CAPITAL PARTNERS, LLC | 125,000 | 683,000 | 0.90% | ||
| 20 | TWO SIGMA INVESTMENTS, LP | 116,581 | 637,000 | 0.84% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 109,839 | 599,000 | 0.79% | ||
| 22 | MACQUARIE GROUP LTD | 80,000 | 437,000 | 0.58% | ||
| 23 | MORGAN STANLEY | 76,731 | 419,000 | 0.55% | ||
| 24 | Ghost Tree Capital, LLC | 75,000 | 410,000 | 0.54% | ||
| 25 | Candriam S.C.A. | 70,000 | 382,000 | 0.51% | ||
| 26 | Bank of New York Mellon Corp | 60,872 | 332,000 | 0.44% | ||
| 27 | JPMORGAN CHASE & CO | 56,410 | 308,000 | 0.41% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,372 | 275,000 | 0.36% | ||
| 29 | Rhenman & Partners Asset Management AB | 50,000 | 273,000 | 0.36% | ||
| 30 | Trexquant Investment LP | 48,178 | 263,000 | 0.35% | ||
| 31 | TUDOR INVESTMENT CORP ET AL | 45,900 | 251,000 | 0.33% | ||
| 32 | BlackRock Investment Management, LLC | 43,708 | 239,000 | 0.32% | ||
| 33 | CREDIT SUISSE AG/ | 40,787 | 223,000 | 0.29% | ||
| 34 | GOLDMAN SACHS GROUP INC | 37,162 | 203,000 | 0.27% | ||
| 35 | Quantitative Systematic Strategies LLC | 30,004 | 165,000 | 0.22% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,774 | 157,000 | 0.21% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,594 | 145,000 | 0.19% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,200 | 143,000 | 0.19% | Put | |
| 39 | ALLIANCEBERNSTEIN L.P. | 22,900 | 125,000 | 0.17% | ||
| 40 | CITADEL ADVISORS LLC | 22,064 | 120,000 | 0.16% | ||
| 41 | UBS Group AG | 21,997 | 120,000 | 0.16% | ||
| 42 | Swiss National Bank | 21,000 | 115,000 | 0.15% | ||
| 43 | Virtu KCG Holdings LLC | 18,690 | 102,000 | 0.13% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,048 | 99,000 | 0.13% | ||
| 45 | SG Americas Securities, LLC | 18,049 | 99,000 | 0.13% | ||
| 46 | SOCIETE GENERALE | 18,049 | 99,000 | 0.13% | ||
| 47 | TEACHERS ADVISORS, LLC | 16,467 | 90,000 | 0.12% | ||
| 48 | RHUMBLINE ADVISERS | 12,987 | 71,000 | 0.09% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 11,900 | 65,000 | 0.09% | ||
| 50 | A.R.T. Advisors, LLC | 11,852 | 64,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
