| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 3,268,556 | 69,947,000 | 19.88% | ||
| 2 | FMR LLC | 2,611,629 | 55,889,000 | 15.89% | ||
| 3 | AVIVA HOLDINGS LTD. | 1,546,001 | 33,328,000 | 9.47% | ||
| 4 | Avoro Capital Advisors LLC | 1,404,055 | 30,047,000 | 8.54% | ||
| 5 | BOXER CAPITAL, LLC | 757,935 | 16,220,000 | 4.61% | ||
| 6 | FRANKLIN RESOURCES INC | 613,996 | 13,140,000 | 3.74% | ||
| 7 | Visium Asset Management, LP | 608,024 | 13,012,000 | 3.70% | ||
| 8 | QVT Financial LP | 558,625 | 11,955,000 | 3.40% | ||
| 9 | VANGUARD GROUP INC | 556,315 | 11,905,000 | 3.38% | ||
| 10 | Cormorant Asset Management, LP | 495,356 | 10,601,000 | 3.01% | ||
| 11 | RTW INVESTMENTS, LP | 428,457 | 9,169,000 | 2.61% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 358,082 | 7,663,000 | 2.18% | ||
| 13 | STATE STREET CORP | 350,525 | 7,498,000 | 2.13% | ||
| 14 | BlackRock Fund Advisors | 300,608 | 6,433,000 | 1.83% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 273,000 | 5,842,000 | 1.66% | ||
| 16 | Ghost Tree Capital, LLC | 250,000 | 5,350,000 | 1.52% | ||
| 17 | ORBIMED ADVISORS LLC | 197,859 | 4,234,000 | 1.20% | ||
| 18 | Broadfin Capital, LLC | 193,863 | 4,149,000 | 1.18% | ||
| 19 | DEUTSCHE BANK AG\ | 184,242 | 3,942,000 | 1.12% | ||
| 20 | NORTHERN TRUST CORP | 142,747 | 3,055,000 | 0.87% | ||
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 125,178 | 2,679,000 | 0.76% | ||
| 22 | Candriam S.C.A. | 104,000 | 2,214,000 | 0.63% | ||
| 23 | ACUTA CAPITAL PARTNERS, LLC | 103,283 | 2,210,000 | 0.63% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 102,128 | 2,185,000 | 0.62% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 94,676 | 2,026,000 | 0.58% | ||
| 26 | JPMORGAN CHASE & CO | 77,160 | 1,651,000 | 0.47% | ||
| 27 | JENNISON ASSOCIATES LLC | 65,789 | 1,408,000 | 0.40% | ||
| 28 | Bank of New York Mellon Corp | 61,103 | 1,307,000 | 0.37% | ||
| 29 | OXFORD ASSET MANAGEMENT LLP | 58,158 | 1,245,000 | 0.35% | ||
| 30 | SABBY MANAGEMENT, LLC | 56,400 | 1,207,000 | 0.34% | ||
| 31 | Rhenman & Partners Asset Management AB | 50,000 | 1,070,000 | 0.30% | ||
| 32 | MORGAN STANLEY | 48,203 | 1,032,000 | 0.29% | ||
| 33 | BlackRock Investment Management, LLC | 40,605 | 869,000 | 0.25% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 35,395 | 757,000 | 0.22% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,294 | 520,000 | 0.15% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,201 | 497,000 | 0.14% | ||
| 37 | Swiss National Bank | 21,000 | 434,000 | 0.12% | ||
| 38 | UBS Group AG | 20,066 | 429,000 | 0.12% | ||
| 39 | ROYAL BANK OF CANADA | 19,250 | 412,000 | 0.12% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,048 | 387,000 | 0.11% | ||
| 41 | TEACHERS ADVISORS, LLC | 16,467 | 352,000 | 0.10% | ||
| 42 | CREDIT SUISSE AG/ | 14,596 | 312,000 | 0.09% | ||
| 43 | CITADEL ADVISORS LLC | 12,806 | 274,000 | 0.08% | ||
| 44 | CITIGROUP INC | 12,528 | 269,000 | 0.08% | ||
| 45 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 11,950 | 256,000 | 0.07% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 11,900 | 255,000 | 0.07% | ||
| 47 | AQR CAPITAL MANAGEMENT LLC | 11,525 | 247,000 | 0.07% | ||
| 48 | RHUMBLINE ADVISERS | 11,097 | 237,000 | 0.07% | ||
| 49 | METROPOLITAN LIFE INSURANCE CO/NY | 10,368 | 222,000 | 0.06% | ||
| 50 | Boulegeris Investments, Inc. | 9,425 | 202,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
