| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,269,198 | 14,999,000 | 18.60% | ||
| 2 | AVIVA HOLDINGS LTD. | 1,992,085 | 13,168,000 | 16.33% | ||
| 3 | Avoro Capital Advisors LLC | 1,488,487 | 9,839,000 | 12.20% | ||
| 4 | Broadfin Capital, LLC | 1,000,000 | 6,610,000 | 8.19% | ||
| 5 | BOXER CAPITAL, LLC | 757,935 | 5,010,000 | 6.21% | ||
| 6 | VANGUARD GROUP INC | 751,697 | 4,969,000 | 6.16% | ||
| 7 | FRANKLIN RESOURCES INC | 613,996 | 4,059,000 | 5.03% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 364,284 | 2,408,000 | 2.99% | ||
| 9 | BlackRock Fund Advisors | 348,366 | 2,303,000 | 2.86% | ||
| 10 | Ghost Tree Capital, LLC | 275,000 | 1,818,000 | 2.25% | ||
| 11 | GREAT POINT PARTNERS LLC | 227,657 | 1,505,000 | 1.87% | ||
| 12 | STATE STREET CORP | 169,234 | 1,120,000 | 1.39% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 992,000 | 1.23% | ||
| 14 | NORTHERN TRUST CORP | 146,142 | 966,000 | 1.20% | ||
| 15 | RTW INVESTMENTS, LP | 129,129 | 854,000 | 1.06% | ||
| 16 | ACUTA CAPITAL PARTNERS, LLC | 125,000 | 826,000 | 1.02% | ||
| 17 | DEUTSCHE BANK AG\ | 119,232 | 787,000 | 0.98% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 106,800 | 706,000 | 0.88% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 106,922 | 706,000 | 0.88% | ||
| 20 | SABBY MANAGEMENT, LLC | 99,735 | 659,000 | 0.82% | ||
| 21 | MACQUARIE GROUP LTD | 80,000 | 529,000 | 0.66% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 79,147 | 523,000 | 0.65% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 76,301 | 504,000 | 0.62% | ||
| 24 | AQR CAPITAL MANAGEMENT LLC | 70,532 | 466,000 | 0.58% | ||
| 25 | GOLDMAN SACHS GROUP INC | 68,076 | 450,000 | 0.56% | ||
| 26 | Bank of New York Mellon Corp | 54,294 | 359,000 | 0.45% | ||
| 27 | Rhenman & Partners Asset Management AB | 50,000 | 330,500 | 0.41% | ||
| 28 | BlackRock Investment Management, LLC | 43,605 | 288,000 | 0.36% | ||
| 29 | MORGAN STANLEY | 37,400 | 247,000 | 0.31% | ||
| 30 | GSA CAPITAL PARTNERS LLP | 34,999 | 231,000 | 0.29% | ||
| 31 | JPMORGAN CHASE & CO | 30,060 | 199,000 | 0.25% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,494 | 175,000 | 0.22% | ||
| 33 | ALLIANCEBERNSTEIN L.P. | 22,900 | 151,000 | 0.19% | ||
| 34 | CREDIT SUISSE AG/ | 22,058 | 145,000 | 0.18% | ||
| 35 | Trexquant Investment LP | 21,833 | 144,000 | 0.18% | ||
| 36 | UBS Group AG | 21,503 | 142,000 | 0.18% | ||
| 37 | Swiss National Bank | 21,000 | 139,000 | 0.17% | ||
| 38 | Tower Research Capital LLC (TRC) | 20,214 | 134,000 | 0.17% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,048 | 120,000 | 0.15% | ||
| 40 | CITADEL ADVISORS LLC | 16,493 | 109,000 | 0.14% | ||
| 41 | TUDOR INVESTMENT CORP ET AL | 15,957 | 105,000 | 0.13% | ||
| 42 | TEACHERS ADVISORS, LLC | 14,438 | 95,000 | 0.12% | ||
| 43 | RHUMBLINE ADVISERS | 13,087 | 87,000 | 0.11% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 11,900 | 79,000 | 0.10% | ||
| 45 | D. E. Shaw & Co., Inc. | 10,977 | 73,000 | 0.09% | ||
| 46 | TFS CAPITAL LLC | 10,613 | 70,000 | 0.09% | ||
| 47 | BLACKROCK ADVISORS LLC | 7,840 | 52,000 | 0.06% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 7,319 | 48,379 | 0.06% | ||
| 49 | Nationwide Fund Advisors | 7,245 | 48,000 | 0.06% | ||
| 50 | Financial Architects, Inc | 6,050 | 40,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
