| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,805,074 | 88,276,000 | 25.40% | ||
| 2 | FMR LLC | 2,424,075 | 76,286,000 | 21.95% | ||
| 3 | Avoro Capital Advisors LLC | 1,000,000 | 31,470,000 | 9.06% | ||
| 4 | FRANKLIN RESOURCES INC | 825,846 | 25,989,000 | 7.48% | ||
| 5 | ORBIMED ADVISORS LLC | 680,500 | 21,415,000 | 6.16% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 397,660 | 12,514,000 | 3.60% | ||
| 7 | Broadfin Capital, LLC | 359,661 | 11,319,000 | 3.26% | ||
| 8 | VANGUARD GROUP INC | 292,762 | 9,213,000 | 2.65% | ||
| 9 | QVT Financial LP | 292,522 | 9,206,000 | 2.65% | ||
| 10 | BlackRock Fund Advisors | 261,747 | 8,237,000 | 2.37% | ||
| 11 | LORD, ABBETT & CO. LLC | 162,506 | 5,114,000 | 1.47% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 130,046 | 4,093,000 | 1.18% | ||
| 13 | STATE STREET CORP | 117,813 | 3,705,000 | 1.07% | ||
| 14 | Candriam S.C.A. | 110,000 | 3,462,000 | 1.00% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 95,000 | 2,990,000 | 0.86% | ||
| 16 | NORTHERN TRUST CORP | 84,871 | 2,671,000 | 0.77% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 83,572 | 2,630,000 | 0.76% | ||
| 18 | JPMORGAN CHASE & CO | 79,400 | 2,499,000 | 0.72% | ||
| 19 | First Eagle Investment Management, LLC | 62,813 | 1,977,000 | 0.57% | ||
| 20 | Artal Group S.A. | 61,276 | 1,928,000 | 0.55% | ||
| 21 | MORGAN STANLEY | 52,970 | 1,667,000 | 0.48% | ||
| 22 | Lombard Odier Asset Management (USA) Corp | 50,722 | 1,596,000 | 0.46% | ||
| 23 | Rhenman & Partners Asset Management AB | 50,000 | 1,574,000 | 0.45% | ||
| 24 | Informed Momentum Co LLC | 38,754 | 1,220,000 | 0.35% | ||
| 25 | Bank of New York Mellon Corp | 35,166 | 1,107,000 | 0.32% | ||
| 26 | BlackRock Investment Management, LLC | 34,991 | 1,101,000 | 0.32% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,823 | 1,096,000 | 0.32% | ||
| 28 | RUSSELL FRANK CO/ | 33,774 | 1,063,000 | 0.31% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,632 | 1,058,000 | 0.30% | ||
| 30 | Spark Investment Management LLC | 25,900 | 815,000 | 0.23% | ||
| 31 | Integre Asset Management, LLC | 23,996 | 755,000 | 0.22% | ||
| 32 | UBS Group AG | 18,318 | 576,000 | 0.17% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,191 | 572,000 | 0.16% | ||
| 34 | ROYAL BANK OF CANADA | 17,899 | 563,000 | 0.16% | ||
| 35 | Boulegeris Investments, Inc. | 17,415 | 548,000 | 0.16% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,100 | 538,000 | 0.15% | Put | |
| 37 | TEACHERS ADVISORS, LLC | 14,465 | 455,000 | 0.13% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,248 | 449,000 | 0.13% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,200 | 447,000 | 0.13% | Call | |
| 40 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 14,200 | 447,000 | 0.13% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 13,341 | 419,000 | 0.12% | ||
| 42 | AQR CAPITAL MANAGEMENT LLC | 12,451 | 392,000 | 0.11% | ||
| 43 | OPPENHEIMER & CO INC | 11,001 | 346,000 | 0.10% | ||
| 44 | LOGAN CAPITAL MANAGEMENT INC | 10,000 | 315,000 | 0.09% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 9,969 | 314,000 | 0.09% | ||
| 46 | PDT Partners, LLC | 8,952 | 282,000 | 0.08% | ||
| 47 | Swiss National Bank | 8,600 | 271,000 | 0.08% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 8,323 | 262,000 | 0.08% | ||
| 49 | RHUMBLINE ADVISERS | 8,245 | 259,000 | 0.07% | ||
| 50 | Sio Capital Management, LLC | 8,008 | 252,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
