| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,805,074 | 82,245,000 | 25.85% | ||
| 2 | FMR LLC | 2,424,075 | 71,074,000 | 22.34% | ||
| 3 | ORBIMED ADVISORS LLC | 1,267,000 | 37,148,000 | 11.68% | ||
| 4 | FRANKLIN RESOURCES INC | 802,846 | 23,539,000 | 7.40% | ||
| 5 | QVT Financial LP | 456,466 | 13,384,000 | 4.21% | ||
| 6 | TANG CAPITAL MANAGEMENT LLC | 388,543 | 11,392,000 | 3.58% | ||
| 7 | Avoro Capital Advisors LLC | 320,867 | 9,408,000 | 2.96% | ||
| 8 | Broadfin Capital, LLC | 306,463 | 8,985,000 | 2.82% | ||
| 9 | VANGUARD GROUP INC | 278,554 | 8,167,000 | 2.57% | ||
| 10 | Artal Group S.A. | 250,000 | 7,330,000 | 2.30% | ||
| 11 | BlackRock Fund Advisors | 240,762 | 7,059,000 | 2.22% | ||
| 12 | First Eagle Investment Management, LLC | 119,912 | 3,516,000 | 1.11% | ||
| 13 | Candriam S.C.A. | 114,000 | 3,343,000 | 1.05% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 2,932,000 | 0.92% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 91,942 | 2,696,000 | 0.85% | ||
| 16 | STATE STREET CORP | 89,796 | 2,633,000 | 0.83% | ||
| 17 | JPMORGAN CHASE & CO | 85,325 | 2,502,000 | 0.79% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 71,620 | 2,100,000 | 0.66% | ||
| 19 | NORTHERN TRUST CORP | 69,531 | 2,038,000 | 0.64% | ||
| 20 | BAILARD, INC. | 57,000 | 1,671,000 | 0.53% | ||
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 52,342 | 1,535,000 | 0.48% | ||
| 22 | Sio Capital Management, LLC | 46,677 | 1,369,000 | 0.43% | ||
| 23 | DEERFIELD MANAGEMENT COMPANY, L.P. | 32,912 | 965,000 | 0.30% | ||
| 24 | DEUTSCHE BANK AG\ | 27,533 | 806,000 | 0.25% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,309 | 801,000 | 0.25% | ||
| 26 | PointState Capital LP | 25,000 | 733,000 | 0.23% | ||
| 27 | Opus Point Partners Management, LLC | 25,000 | 733,000 | 0.23% | ||
| 28 | BlackRock Investment Management, LLC | 24,725 | 725,000 | 0.23% | ||
| 29 | Integre Asset Management, LLC | 24,270 | 712,000 | 0.22% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 23,900 | 701,000 | 0.22% | ||
| 31 | Bank of New York Mellon Corp | 22,718 | 666,000 | 0.21% | ||
| 32 | UBS Group AG | 19,831 | 581,000 | 0.18% | ||
| 33 | ROYAL BANK OF CANADA | 17,752 | 520,000 | 0.16% | ||
| 34 | MORGAN STANLEY | 16,811 | 493,000 | 0.15% | ||
| 35 | Boulegeris Investments, Inc. | 16,500 | 484,000 | 0.15% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,632 | 458,000 | 0.14% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 11,927 | 349,000 | 0.11% | ||
| 38 | TEACHERS ADVISORS, LLC | 11,439 | 335,000 | 0.11% | ||
| 39 | Spark Investment Management LLC | 11,200 | 327,000 | 0.10% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,500 | 308,000 | 0.10% | ||
| 41 | LOGAN CAPITAL MANAGEMENT INC | 8,900 | 261,000 | 0.08% | ||
| 42 | METROPOLITAN LIFE INSURANCE CO/NY | 7,338 | 215,000 | 0.07% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,552 | 162,000 | 0.05% | ||
| 44 | Nationwide Fund Advisors | 5,456 | 160,000 | 0.05% | ||
| 45 | Financial Architects, Inc | 5,000 | 147,000 | 0.05% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 4,511 | 132,263 | 0.04% | ||
| 47 | BLACKROCK ADVISORS LLC | 4,136 | 121,000 | 0.04% | ||
| 48 | WELLS FARGO & COMPANY/MN | 2,337 | 69,000 | 0.02% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 1,500 | 44,000 | 0.01% | ||
| 50 | CITIGROUP INC | 470 | 13,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
