| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,955,074 | 101,714,000 | 21.05% | ||
| 2 | FMR LLC | 2,789,688 | 96,021,000 | 19.87% | ||
| 3 | Avoro Capital Advisors LLC | 1,453,055 | 50,014,000 | 10.35% | ||
| 4 | FRANKLIN RESOURCES INC | 676,640 | 23,290,000 | 4.82% | ||
| 5 | RTW INVESTMENTS, LP | 482,069 | 16,593,000 | 3.43% | ||
| 6 | Visium Asset Management, LP | 425,000 | 14,629,000 | 3.03% | ||
| 7 | VANGUARD GROUP INC | 420,424 | 14,471,000 | 2.99% | ||
| 8 | CITIGROUP INC | 341,821 | 11,766,000 | 2.43% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 320,960 | 11,047,000 | 2.29% | ||
| 10 | COLUMBUS CIRCLE INVESTORS | 305,780 | 10,525,000 | 2.18% | ||
| 11 | BlackRock Fund Advisors | 299,790 | 10,319,000 | 2.14% | ||
| 12 | Broadfin Capital, LLC | 295,700 | 10,178,000 | 2.11% | ||
| 13 | QVT Financial LP | 277,733 | 9,560,000 | 1.98% | ||
| 14 | Cormorant Asset Management, LP | 255,000 | 8,777,000 | 1.82% | ||
| 15 | ORBIMED ADVISORS LLC | 240,000 | 8,261,000 | 1.71% | ||
| 16 | DEUTSCHE BANK AG\ | 186,018 | 6,401,000 | 1.32% | ||
| 17 | DRIEHAUS CAPITAL MANAGEMENT LLC | 150,812 | 5,191,000 | 1.07% | ||
| 18 | STATE STREET CORP | 142,639 | 4,909,000 | 1.02% | ||
| 19 | MORGAN STANLEY | 130,587 | 4,495,000 | 0.93% | ||
| 20 | NORTHERN TRUST CORP | 126,940 | 4,370,000 | 0.90% | ||
| 21 | EverPoint Asset Management, LLC | 125,000 | 4,303,000 | 0.89% | ||
| 22 | CITADEL ADVISORS LLC | 122,126 | 4,203,000 | 0.87% | ||
| 23 | DEERFIELD MANAGEMENT COMPANY, L.P. | 110,049 | 3,788,000 | 0.78% | ||
| 24 | Candriam S.C.A. | 107,000 | 3,683,000 | 0.76% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 93,500 | 3,218,000 | 0.67% | ||
| 26 | JPMORGAN CHASE & CO | 81,525 | 2,806,000 | 0.58% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 80,000 | 2,754,000 | 0.57% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,800 | 2,471,000 | 0.51% | Call | |
| 29 | JENNISON ASSOCIATES LLC | 65,000 | 2,237,000 | 0.46% | ||
| 30 | SABBY MANAGEMENT, LLC | 60,000 | 2,065,000 | 0.43% | ||
| 31 | Sio Capital Management, LLC | 57,605 | 1,983,000 | 0.41% | ||
| 32 | Bank of New York Mellon Corp | 57,051 | 1,963,000 | 0.41% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,600 | 1,914,000 | 0.40% | Put | |
| 34 | Rhenman & Partners Asset Management AB | 50,000 | 1,721,000 | 0.36% | ||
| 35 | BlackRock Investment Management, LLC | 39,464 | 1,358,000 | 0.28% | ||
| 36 | Trexquant Investment LP | 36,100 | 1,242,000 | 0.26% | ||
| 37 | GRATICULE ASIA MACRO ADVISORS LLC | 36,043 | 1,241,000 | 0.26% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 32,729 | 1,127,000 | 0.23% | ||
| 39 | CREDIT SUISSE AG/ | 30,538 | 1,051,000 | 0.22% | ||
| 40 | TFS CAPITAL LLC | 30,436 | 1,048,000 | 0.22% | ||
| 41 | Informed Momentum Co LLC | 25,230 | 868,000 | 0.18% | ||
| 42 | Integre Asset Management, LLC | 24,258 | 835,000 | 0.17% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,991 | 723,000 | 0.15% | ||
| 44 | RUSSELL FRANK CO/ | 20,127 | 693,000 | 0.14% | ||
| 45 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 19,950 | 687,000 | 0.14% | ||
| 46 | PDT Partners, LLC | 18,600 | 640,000 | 0.13% | ||
| 47 | MILLENNIUM MANAGEMENT LLC | 18,472 | 636,000 | 0.13% | ||
| 48 | Boulegeris Investments, Inc. | 18,240 | 628,000 | 0.13% | ||
| 49 | ArrowMark Colorado Holdings LLC | 17,122 | 589,000 | 0.12% | ||
| 50 | UBS Group AG | 16,682 | 575,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
