| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,380,074 | 41,675,000 | 29.67% | ||
| 2 | FMR LLC | 1,244,275 | 21,787,000 | 15.51% | ||
| 3 | ORBIMED ADVISORS LLC | 1,167,000 | 20,434,000 | 14.55% | ||
| 4 | FRANKLIN RESOURCES INC | 871,345 | 15,257,000 | 10.86% | ||
| 5 | QVT Financial LP | 507,184 | 8,573,000 | 6.10% | ||
| 6 | TANG CAPITAL MANAGEMENT LLC | 288,432 | 5,050,000 | 3.60% | ||
| 7 | Artal Group S.A. | 250,000 | 4,378,000 | 3.12% | ||
| 8 | VANGUARD GROUP INC | 214,358 | 3,754,000 | 2.67% | ||
| 9 | Broadfin Capital, LLC | 184,756 | 3,235,000 | 2.30% | ||
| 10 | BlackRock Fund Advisors | 169,573 | 2,969,000 | 2.11% | ||
| 11 | First Eagle Investment Management, LLC | 99,912 | 1,749,000 | 1.25% | ||
| 12 | JPMORGAN CHASE & CO | 93,125 | 1,631,000 | 1.16% | ||
| 13 | DRIEHAUS CAPITAL MANAGEMENT LLC | 90,188 | 1,579,000 | 1.12% | ||
| 14 | NORTHERN TRUST CORP | 63,972 | 1,120,000 | 0.80% | ||
| 15 | STATE STREET CORP | 63,980 | 1,119,000 | 0.80% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 57,960 | 1,015,000 | 0.72% | ||
| 17 | GOLDMAN SACHS GROUP INC | 36,685 | 642,000 | 0.46% | ||
| 18 | BAILARD, INC. | 34,000 | 595,000 | 0.42% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,630 | 484,000 | 0.34% | ||
| 20 | MORGAN STANLEY | 27,006 | 474,000 | 0.34% | ||
| 21 | Integre Asset Management, LLC | 22,767 | 399,000 | 0.28% | ||
| 22 | Bank of New York Mellon Corp | 21,141 | 370,000 | 0.26% | ||
| 23 | BlackRock Investment Management, LLC | 20,247 | 355,000 | 0.25% | ||
| 24 | DEUTSCHE BANK AG\ | 20,171 | 353,000 | 0.25% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,175 | 231,000 | 0.16% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,500 | 184,000 | 0.13% | ||
| 27 | TEACHERS ADVISORS, LLC | 10,258 | 180,000 | 0.13% | ||
| 28 | UBS AG | 9,950 | 174,000 | 0.12% | ||
| 29 | ROYAL BANK OF CANADA | 9,502 | 167,000 | 0.12% | ||
| 30 | Tower Research Capital LLC (TRC) | 5,588 | 98,000 | 0.07% | ||
| 31 | Nationwide Fund Advisors | 5,265 | 92,000 | 0.07% | ||
| 32 | AMERICAN INTERNATIONAL GROUP, INC. | 4,690 | 82,122 | 0.06% | ||
| 33 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 3,574 | 63,000 | 0.04% | ||
| 34 | Financial Architects, Inc | 3,000 | 53,000 | 0.04% | ||
| 35 | BLACKROCK ADVISORS LLC | 2,975 | 52,000 | 0.04% | ||
| 36 | STRS OHIO | 2,400 | 42,000 | 0.03% | ||
| 37 | WELLS FARGO & COMPANY/MN | 1,007 | 18,000 | 0.01% | ||
| 38 | ALLIANCEBERNSTEIN L.P. | 400 | 7,000 | 0.00% | ||
| 39 | Ground Swell Capital, LLC | 273 | 5,000 | 0.00% | ||
| 40 | CITIGROUP INC | 250 | 4,000 | 0.00% | ||
| 41 | BARCLAYS PLC | 236 | 4,000 | 0.00% | ||
| 42 | BNP PARIBAS FINANCIAL MARKETS | 120 | 2,101 | 0.00% | ||
| 43 | B. Riley Wealth Management, Inc. | 82 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
