| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,269,198 | 10,779,000 | 19.06% | ||
| 2 | AVIVA HOLDINGS LTD. | 1,992,085 | 9,462,000 | 16.73% | ||
| 3 | Avoro Capital Advisors LLC | 1,508,201 | 7,164,000 | 12.67% | ||
| 4 | GREAT POINT PARTNERS LLC | 870,261 | 4,134,000 | 7.31% | ||
| 5 | Broadfin Capital, LLC | 826,001 | 3,924,000 | 6.94% | ||
| 6 | BOXER CAPITAL, LLC | 757,935 | 3,600,000 | 6.37% | ||
| 7 | VANGUARD GROUP INC | 523,812 | 2,488,000 | 4.40% | ||
| 8 | BlackRock Fund Advisors | 399,317 | 1,897,000 | 3.35% | ||
| 9 | FRANKLIN RESOURCES INC | 377,646 | 1,794,000 | 3.17% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 352,282 | 1,673,000 | 2.96% | ||
| 11 | STATE STREET CORP | 190,179 | 905,000 | 1.60% | ||
| 12 | Ghost Tree Capital, LLC | 172,184 | 818,000 | 1.45% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 161,305 | 766,000 | 1.35% | ||
| 14 | NORTHERN TRUST CORP | 141,665 | 673,000 | 1.19% | ||
| 15 | RTW INVESTMENTS, LP | 129,697 | 616,000 | 1.09% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 109,262 | 518,000 | 0.92% | ||
| 17 | SABBY MANAGEMENT, LLC | 99,735 | 474,000 | 0.84% | ||
| 18 | SPHERA FUNDS MANAGEMENT LTD. | 80,528 | 383,000 | 0.68% | ||
| 19 | MACQUARIE GROUP LTD | 80,000 | 380,000 | 0.67% | ||
| 20 | MORGAN STANLEY | 69,101 | 329,000 | 0.58% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 68,275 | 324,000 | 0.57% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 60,041 | 285,000 | 0.50% | ||
| 23 | AQR CAPITAL MANAGEMENT LLC | 57,337 | 272,000 | 0.48% | ||
| 24 | JPMORGAN CHASE & CO | 54,261 | 258,000 | 0.46% | ||
| 25 | Bank of New York Mellon Corp | 51,251 | 244,000 | 0.43% | ||
| 26 | Rhenman & Partners Asset Management AB | 50,000 | 238,000 | 0.42% | ||
| 27 | D. E. Shaw & Co., Inc. | 50,115 | 238,000 | 0.42% | ||
| 28 | BlackRock Investment Management, LLC | 43,605 | 207,000 | 0.37% | ||
| 29 | DEUTSCHE BANK AG\ | 32,836 | 155,000 | 0.27% | ||
| 30 | UBS Group AG | 27,240 | 130,000 | 0.23% | ||
| 31 | Trexquant Investment LP | 26,432 | 126,000 | 0.22% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,094 | 124,000 | 0.22% | ||
| 33 | CREDIT SUISSE AG/ | 23,639 | 113,000 | 0.20% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,127 | 110,000 | 0.19% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 22,900 | 109,000 | 0.19% | ||
| 36 | TFS CAPITAL LLC | 22,826 | 108,000 | 0.19% | ||
| 37 | TEACHERS ADVISORS, LLC | 18,786 | 89,000 | 0.16% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,048 | 86,000 | 0.15% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 11,900 | 57,000 | 0.10% | ||
| 40 | WEDBUSH SECURITIES INC | 12,100 | 57,000 | 0.10% | ||
| 41 | RHUMBLINE ADVISERS | 11,629 | 55,000 | 0.10% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,400 | 54,000 | 0.10% | Put | |
| 43 | BLACKROCK ADVISORS LLC | 8,163 | 39,000 | 0.07% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 7,299 | 35,000 | 0.06% | ||
| 45 | Nationwide Fund Advisors | 7,245 | 34,000 | 0.06% | ||
| 46 | CUTLER GROUP LLC / CA | 6,340 | 30,000 | 0.05% | ||
| 47 | CUTLER GROUP LLC / CA | 11,800 | 29,000 | 0.05% | Put | |
| 48 | Financial Architects, Inc | 6,050 | 29,000 | 0.05% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 4,811 | 23,000 | 0.04% | ||
| 50 | BlackRock Finance, Inc. | 3,899 | 19,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
