| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,380,074 | 45,388,000 | 26.34% | ||
| 2 | FMR LLC | 1,434,261 | 27,351,000 | 15.87% | ||
| 3 | ORBIMED ADVISORS LLC | 1,274,332 | 24,302,000 | 14.10% | ||
| 4 | FRANKLIN RESOURCES INC | 888,746 | 16,948,000 | 9.83% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 656,767 | 12,525,000 | 7.27% | ||
| 6 | QVT Financial LP | 533,878 | 10,181,000 | 5.91% | ||
| 7 | TANG CAPITAL MANAGEMENT LLC | 435,843 | 8,312,000 | 4.82% | ||
| 8 | Artal Group S.A. | 250,000 | 4,768,000 | 2.77% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 238,030 | 4,539,000 | 2.63% | ||
| 10 | VANGUARD GROUP INC | 193,250 | 3,685,000 | 2.14% | ||
| 11 | Broadfin Capital, LLC | 184,756 | 3,523,000 | 2.04% | ||
| 12 | First Eagle Investment Management, LLC | 149,912 | 2,859,000 | 1.66% | ||
| 13 | BVF INC/IL | 74,900 | 1,428,000 | 0.83% | ||
| 14 | MORGAN STANLEY | 55,315 | 1,054,000 | 0.61% | ||
| 15 | Spark Investment Management LLC | 41,300 | 784,000 | 0.45% | ||
| 16 | ONTARIO TEACHERS PENSION PLAN BOARD | 39,115 | 746,000 | 0.43% | ||
| 17 | UBS AG | 36,383 | 694,000 | 0.40% | ||
| 18 | BAILARD, INC. | 34,000 | 648,000 | 0.38% | ||
| 19 | GOLDMAN SACHS GROUP INC | 28,447 | 542,000 | 0.31% | ||
| 20 | BlackRock Group LTD | 22,303 | 425,000 | 0.25% | ||
| 21 | DEUTSCHE BANK AG\ | 21,378 | 406,000 | 0.24% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 21,000 | 400,000 | 0.23% | ||
| 23 | CREDIT SUISSE AG/ | 13,000 | 248,000 | 0.14% | ||
| 24 | JANE STREET GROUP, LLC | 11,080 | 211,000 | 0.12% | ||
| 25 | ROYAL BANK OF CANADA | 9,902 | 189,000 | 0.11% | ||
| 26 | WELLS FARGO & COMPANY/MN | 3,559 | 68,000 | 0.04% | ||
| 27 | Tower Research Capital LLC (TRC) | 2,678 | 52,000 | 0.03% | ||
| 28 | BlackRock Institutional Trust Company, N.A. | 2,224 | 42,000 | 0.02% | ||
| 29 | BARCLAYS PLC | 887 | 17,000 | 0.01% | ||
| 30 | TradeLink Global Equity LLC | 500 | 10,000 | 0.01% | ||
| 31 | B. Riley Wealth Management, Inc. | 82 | 2,000 | 0.00% | ||
| 32 | CITIGROUP INC | 29 | 1,000 | 0.00% | ||
| 33 | BlackRock Finance, Inc. | 19 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
