| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,201,943 | 28,882,000 | 18.47% | ||
| 2 | Broadfin Capital, LLC | 2,558,854 | 22,884,000 | 14.63% | ||
| 3 | QVT Financial LP | 2,322,457 | 20,690,000 | 13.23% | ||
| 4 | Consonance Capital Management LP | 1,539,459 | 13,886,000 | 8.88% | ||
| 5 | Opaleye Management Inc. | 1,000,000 | 9,020,000 | 5.77% | ||
| 6 | PUTNAM INVESTMENTS LLC | 937,378 | 8,455,000 | 5.41% | ||
| 7 | Lombard Odier Asset Management (USA) Corp | 900,000 | 8,118,000 | 5.19% | ||
| 8 | BlackRock Fund Advisors | 516,455 | 4,658,000 | 2.98% | ||
| 9 | Amici Capital, LLC | 495,000 | 4,465,000 | 2.85% | ||
| 10 | VANGUARD GROUP INC | 407,019 | 3,672,000 | 2.35% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 366,542 | 3,306,000 | 2.11% | ||
| 12 | TURNER INVESTMENTS LLC | 341,500 | 3,080,000 | 1.97% | ||
| 13 | SENZAR ASSET MANAGEMENT, LLC | 292,400 | 2,637,000 | 1.69% | ||
| 14 | ASCEND CAPITAL, LLC | 285,000 | 2,571,000 | 1.64% | ||
| 15 | STATE STREET CORP | 281,098 | 2,537,000 | 1.62% | ||
| 16 | Visium Asset Management, LP | 249,092 | 2,247,000 | 1.44% | ||
| 17 | NORTHERN TRUST CORP | 221,129 | 1,995,000 | 1.28% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 203,052 | 1,832,000 | 1.17% | ||
| 19 | DEUTSCHE BANK AG\ | 137,951 | 1,243,000 | 0.79% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 135,389 | 1,221,000 | 0.78% | ||
| 21 | Bank of New York Mellon Corp | 102,107 | 921,000 | 0.59% | ||
| 22 | Connor, Clark & Lunn Investment Management Ltd. | 86,600 | 781,000 | 0.50% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 86,393 | 779,000 | 0.50% | ||
| 24 | BlackRock Investment Management, LLC | 60,810 | 549,000 | 0.35% | ||
| 25 | Round Table Services, LLC | 55,350 | 499,000 | 0.32% | ||
| 26 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,550 | 438,000 | 0.28% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,107 | 407,000 | 0.26% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,123 | 353,000 | 0.23% | ||
| 29 | AQR CAPITAL MANAGEMENT LLC | 38,500 | 347,000 | 0.22% | ||
| 30 | Spot Trading L.L.C | 38,400 | 346,000 | 0.22% | Call | |
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,100 | 281,000 | 0.18% | Call | |
| 32 | GSA CAPITAL PARTNERS LLP | 30,444 | 275,000 | 0.18% | ||
| 33 | TEACHERS ADVISORS, LLC | 28,618 | 258,000 | 0.16% | ||
| 34 | GOLDMAN SACHS GROUP INC | 27,164 | 245,000 | 0.16% | ||
| 35 | CREDIT SUISSE AG/ | 27,022 | 244,000 | 0.16% | ||
| 36 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 25,000 | 226,000 | 0.14% | ||
| 37 | D. E. Shaw & Co., Inc. | 21,400 | 193,000 | 0.12% | ||
| 38 | METROPOLITAN LIFE INSURANCE CO/NY | 20,202 | 182,000 | 0.12% | ||
| 39 | DSC Advisors, L.P. | 20,000 | 180,000 | 0.12% | ||
| 40 | RHUMBLINE ADVISERS | 17,138 | 155,000 | 0.10% | ||
| 41 | Nationwide Fund Advisors | 16,387 | 148,000 | 0.09% | ||
| 42 | VOYA INVESTMENT MANAGEMENT LLC | 15,292 | 138,000 | 0.09% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 14,210 | 128,000 | 0.08% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,103 | 127,000 | 0.08% | ||
| 45 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 14,076 | 127,000 | 0.08% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 13,904 | 125,414 | 0.08% | ||
| 47 | BLACKROCK ADVISORS LLC | 11,700 | 106,000 | 0.07% | ||
| 48 | JANE STREET GROUP, LLC | 10,280 | 93,000 | 0.06% | ||
| 49 | DSC Advisors, L.P. | 20,000 | 70,000 | 0.04% | Put | |
| 50 | BANK OF AMERICA CORP /DE/ | 6,198 | 56,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
